Those who live in industrialized countries have easy access to healthy food and nutritional supplements, but magnesium deficiencies are still common. That's a problem because new research from Tel Aviv University suggests that magnesium, a key nutrient for the functioning of memory, may be even more critical than previously thought for the neurons of children and healthy brain cells in adults.
Begun at MIT, the research started as a part of a post-doctoral project by Dr. Inna Slutsky of TAU's Sackler School of Medicine and evolved to become a multi-center experiment focused on a new magnesium supplement, magnesium-L-theronate (MgT), that effectively crosses the blood-brain barrier to inhibit calcium flux in brain neurons.
Published recently in the scientific journal Neuron, the new study found that the synthetic magnesium compound works on both young and aging animals to enhance memory or prevent its impairment. The research was carried out over a five-year period and has significant implications for the use of over-the-counter magnesium supplements.
In the study, two groups of rats ate normal diets containing a healthy amount of magnesium from natural sources. The first group was given a supplement of MgT, while the control group had only its regular diet. Behavioral tests showed that cognitive functioning improved in the rats in the first group and also demonstrated an increase of synapses in the brain connective nerve endings that carry memories in the form of electrical impulses from one part of the brain to the other.
Bad news for today's magnesium supplements
"We are really pleased with the positive results of our studies," says Dr. Slutsky. "But on the negative side, we've also been able to show that today's over-the-counter magnesium supplements don't really work. They do not get into the brain.
"We've developed a promising new compound which has now taken the first important step
|Contact: George Hunka|
American Friends of Tel Aviv University