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Remarkable enzyme points the way to reducing nitric acid use in industry
Date:9/21/2012

ration reaction.

TxtE catalyses the introduction of a nitro group into a specific position of the aromatic ring of the amino acid tryptophan. This is the first key step in the biosynthesis of thaxtomin A.

Thaxtomin A enables Streptomyces scabies to damage potatoes and other root vegetables by inhibiting cellulose production, thereby damaging the cell wall and allowing an infection to take hold.

The enzyme's crucial role in thaxtomin A biosynthesis makes it a potential target for the development of new molecules to block thaxtomin production and thus prevent potato scab, a disease which places a significant economic burden on the agricultural industry globally.


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Contact: Anna Blackaby
a.blackaby@warwick.ac.uk
44-024-765-75910
University of Warwick
Source:Eurekalert

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