Navigation Links
Relationships in rank and file
Date:2/23/2009

Since the sequencing of the human genome eight years ago, enormous progress has been made in analyzing and understanding it. Nevertheless, the function of most human genes is still barely understood. An important first step in determining the function of a gene or protein is to compare its sequence with the sequences of hundreds of other organisms that are experimentally easier to investigate. From the functions of related genes or proteins identified in these database searches, the researchers can often infer the unknown functions of human or animal genes. Now, computational biologists Johannes Soeding and Andreas Biegert of the Gene Center of LMU Munich have successfully developed a method that makes database searches significantly more sensitive, while being just as quick. Instead of comparing sequences letter by letter, their idea is to take the sequence neighbors surrounding each letter into account during the comparison. This idea should be generally applicable in other areas of sequence searching and sequence analysis.

The rule for both genes and proteins is: their function is primarily based on the sequence of their DNA or amino acid components. Genes with similar sequences frequently have a similar function. The same goes for proteins, although for them, the three-dimensional structure into which they fold, and which cannot be predicted offhand from their sequence, is equally important. Still, similar protein sequences suggest relatedness or, in other words, the descent from a common ancestral protein, and with it a similar function.

Accordingly, the sequences and functions of genes and proteins all get stored away into databases, which scientists around the world use for comparing their new data against. But even the best and most frequently used algorithms such as BLAST (Basic Local Alignment Search Tool) have to make use of certain simplifications in order to make efficient searching in the gigantic databases possible at all. After all
'/>"/>

Contact: Luise Dirscherl
dirscherl@lmu.de
49-892-180-2706
Ludwig-Maximilians-Universitt Mnchen
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. In child care, relationships with caregivers key to childrens stress levels
2. UNC, Yale partner to study effects of cocaine use on mother-infant relationships
3. Tree of life for flowering plants reveals relationships among major groups
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/31/2014)... nuts, cashews, hazelnuts, macadamias, pecans, pine nuts, pistachios and ... British Medical Journal Open (BMJ Open) (i) and ... article looked at the effects of tree nuts ... nut consumption resulted in a significant decrease in triglycerides ... article focused on the effect of tree nuts on ...
(Date:7/30/2014)... Society (ACS) announced today that David L. Kaplan, Ph.D., ... Science & Engineering as editor-in-chief. With the first ... journal will feature high-quality research in the rapidly burgeoning ... derived materials that interact with living or biological systems. ... the tremendous growth in the field of biomaterials over ...
(Date:7/30/2014)... The San Antonio Life Sciences Institute (SALSI), a joint ... (UTSA) and The University of Texas Health Science Center ... Postdoc Initiative Pilot Program. The winners, Emily Boice from ... will receive $25,000 for their project titled, "Novel engineered ... post-ischemic environment." , Boice and Huang,s research is focused ...
Breaking Biology News(10 mins):New international tree nut council study looks at nuts, diabetes and metabolic syndrome 2ACS Biomaterials Science & Engineering: Brand-new journal launches in 2015, names editor 2
... the predator-prey relationship can affect the flow of carbon ... environment may offer a new way of looking at ... The study, conducted by researchers at the Yale ... week in the Proceedings of the National Academy ...
... due to rising carbon dioxide levels will reduce the density ... and erosion, according to a new study of corals growing ... The study, led by researchers at the University of ... the National Academy of Sciences ( PNAS ), is ...
... A University of Maryland-led team of policy experts ... of climate change could affect civil conflicts. The team ... socio-economic conditions and climate. They will use these to ... U.S. Department of Defense is funding the research through ...
Cached Biology News:New study shows predators affect the carbon cycle 2Submarine springs reveal how coral reefs respond to ocean acidification 2DoD-funded research: Can climate change heat up conflict? 2
(Date:7/31/2014)... 31, 2014 CollabRx, Inc. (NASDAQ: CLRX), ... decision-making in oncology, today announced that it will hold ... discuss the Company's financial results for the first quarter ... the business in the current fiscal year. , The ... Thursday, August 14, 2014, at 5 p.m. EDT (2 ...
(Date:7/31/2014)... 2014  Smith & Nephew (LSE:SN, NYSE: ... today announced its entry into the forefoot market ... Repair System. Comprised of three separate repair options, ... ligament repair and reconstruction, a metatarsal osteotomy guide, ... (PIP) fusion, also known as hammer toe correction. ...
(Date:7/31/2014)... Held at the Stanford Cancer Center, ... of the disease and its treatment. Survivors will find ... well as updates on the state-of-the-art with respect to ... for organizing this educational opportunity,” says KCA CEO Bill ... her colleagues have put together a program that balances ...
(Date:7/31/2014)... The global market for molecular diagnostics ... according to a new study by Grand View Research, ... the subsequent introduction of advanced cancer diagnostic technologies are ... the next six years. Moreover, the growing global base ... coupled with disease triggering lifestyle habits such as smoking ...
Breaking Biology Technology:CollabRx, Inc. Schedules First Quarter Fiscal Year 2015 Financial Conference Call and Business Update 2Smith & Nephew scores a HAT-TRICK with its entry into the high-growth hammer toe repair market 2Smith & Nephew scores a HAT-TRICK with its entry into the high-growth hammer toe repair market 3Smith & Nephew scores a HAT-TRICK with its entry into the high-growth hammer toe repair market 4Molecular Diagnostics Market - Global Industry Size, Share, Trends, Analysis, Players, Opportunity, Outlook and Forecast From 2014 to 2020 2Molecular Diagnostics Market - Global Industry Size, Share, Trends, Analysis, Players, Opportunity, Outlook and Forecast From 2014 to 2020 3Molecular Diagnostics Market - Global Industry Size, Share, Trends, Analysis, Players, Opportunity, Outlook and Forecast From 2014 to 2020 4Molecular Diagnostics Market - Global Industry Size, Share, Trends, Analysis, Players, Opportunity, Outlook and Forecast From 2014 to 2020 5
... AURORA, Ontario, June 19 Helix BioPharma Corp. (TSX, ... scientific officer at Helix BioPharma Corp., will be presenting ... at the 2009 American Association of Pharmaceutical Scientists ("AAPS") ... 24th at the Washington State Convention and Trade Center ...
... BEIJING, June 19 /PRNewswire-Asia/ -- Sinovac Biotech Ltd.,(NYSE ... of vaccines in China,announced today that the Company received the ... to the Beijing government. The initial order,consists of 4 million ... of,September. This order will be administered to 2 million ...
... and efficacy of Albuferon administered every four weeks in combination ... C - , , ROCKVILLE, Md., June 19 ... announced that Novartis has completed enrollment and initial dosing in ... efficacy of Albuferon(R) (albinterferon alfa-2b) administered monthly in combination with ...
Cached Biology Technology:Helix BioPharma to Present L-DOS47 Analytical Method Development Findings at 2009 AAPS National Biotechnology Conference 2Helix BioPharma to Present L-DOS47 Analytical Method Development Findings at 2009 AAPS National Biotechnology Conference 3Helix BioPharma to Present L-DOS47 Analytical Method Development Findings at 2009 AAPS National Biotechnology Conference 4Helix BioPharma to Present L-DOS47 Analytical Method Development Findings at 2009 AAPS National Biotechnology Conference 5Sinovac Receives China's First Influenza A (H1N1) Vaccine Order 2Sinovac Receives China's First Influenza A (H1N1) Vaccine Order 3Human Genome Sciences Announces Completion of Enrollment in Phase 2b Monthly-Dosing Trial of Albuferon(R) 2Human Genome Sciences Announces Completion of Enrollment in Phase 2b Monthly-Dosing Trial of Albuferon(R) 3Human Genome Sciences Announces Completion of Enrollment in Phase 2b Monthly-Dosing Trial of Albuferon(R) 4
...
... is undoubtedly the most complete and professional ... of layers and subsets makes it is ... different data outputs, for example Cy3 and ... well as different subsets of genes and/or ...
...
...
Biology Products: