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Relationship between environmental stress and cancer elucidated
Date:11/5/2007

u want its activity. When SIRT1 is less active, p53, a tumor suppressor gene that also causes apoptosis, becomes more active.

SIRT1, found throughout the body, is a regulator of protein function through a process called acetylation. MCG researchers also found that sumoylation of SIRT1 (combining it with SUMO1) made it more active and sumoylation motif, which enables SUMO1 to combine with SIRT1, is needed to make that happen.

They have added SUMO1 to human cancer cells and increased SIRT1 activity then used SENP1 to cleave it and reduce activity.

Researchers studying the longevity benefits of SIRT1 have found conflicting information in yeast and mice about whether or not SIRT1 is of benefit. Dr. Yang may have found one reason: mice SIRT1 doesnt contain sumoylation motif. When he created sumoylation motif in mice, SIRT1 activity went up. Dr. Yang will do follow up studies to see if these mice live longer but says SIRT1 may simply have a different function in mice than in humans or yeast, also a common research model.


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Contact: Toni Baker
tbaker@mcg.edu
706-721-4421
Medical College of Georgia  
Source:Eurekalert

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