Navigation Links
Regulatory role of key molecule discovered at Hebrew U.

Jerusalem, Sept. 16, 2009 Discovery by Hebrew University of Jerusalem researchers of an additional role for a key molecule in our bodies provides a further step in world-wide efforts to develop genetic regulation aimed at controlling many diseases, including AIDS and various types of cancers.

The molecule, known as Lysyl-tRNA synthetase (or LysRS in brief) is one of the most ancient molecules in the cell, where it has long been recognized for its contribution in the translation of the information contained in RNA into the amino acids that make up proteins. Amino acids are organic compounds which are present in and vital to every living cell.

Now, the Hebrew University scientists have discovered that LysRS plays an important additional role as a central regulator controlling expression of various genes. In this additional role, LysRS ceases its previous function at a certain point and participates in a chain of events that causes the freeing of inhibitors that prevent expression of certain genes.

The researchers say that this research has particularly great importance, since LysRS is known to be involved in diseases such as AIDS and cancers. The virus HIV uses the host's cellular LysRS in the process of replication. High levels of LysRS also have been observed in certain cancers, such as breast cancer. The specific molecular mechanisms in these contexts remain to be discovered.

An ability to understand the regulatory effect played by LysRS in various diseases could make an important contribution to the worldwide search for therapies that would control the "turning on" or "turning off" of specific genes that are operative in those diseases, they emphasize.


Contact: Jerry Barach
The Hebrew University of Jerusalem

Page: 1

Related biology news :

1. USC researchers identify regulatory genetic sequences that may predict risk for prostate cancer
2. Regulatory molecule for tumor formation or suppression identified by Singapore, US researchers
3. Food counterfeiting, contamination outpace international regulatory systems
4. New data suggest jumping genes play a significant role in gene regulatory networks
5. Caltech researchers help unlock the secrets of gene regulatory networks
6. New regulatory mechanism discovered for cell identify and behavior in forming organs
7. Use of nanomaterials in food packaging poses regulatory challenges
8. Type 1 diabetes triggered by lazy regulatory T-cells: McGill researchers
9. Small molecule inhibits pathology associated with myotonic dystrophy type 1
10. U-Iowa improves delivery of cancer-fighting molecules
11. Microbiologists find defense molecule that senses respiratory viruses
Post Your Comments:
Related Image:
Regulatory role of key molecule discovered at Hebrew U.
(Date:12/1/2015)... Calif. , Dec. 1, 2015 Synaptics ... human interface solutions, today announced a new agreement with ... OEMs with real-world test and development environments that combine ... solutions. The partnership reduces the complexity of FIDO certification ... software permits Synaptics and OEMs to verify FIDO enabled ...
(Date:11/30/2015)... BEACH, Fla. , Nov. 30, 2015 /PRNewswire/ ... as a finalist in this year,s Fierce Innovation Awards:  ... of FierceHealthIT , FierceHealthcare ... was recognized as a finalist in the category ... --> ...
(Date:11/26/2015)... Research and Markets ( ) has ... - Technology and Patent Infringement Risk Analysis" report ... --> Fingerprint sensors using capacitive technology represent ... sensor vendor Idex forecasts an increase of 360% of ... and of the fingerprint sensor market between 2014 and ...
Breaking Biology News(10 mins):
(Date:12/1/2015)... -- Twist Bioscience, a company focused on synthetic DNA, today announced ... selected as one of Foreign Policy,s 100 Leading ... of life . Each year, Foreign Policy selects ... have changed lives and are shaping the world. ... to be recognized among these incredible global leaders," said Leproust. ...
(Date:12/1/2015)... 2015 Oxford Finance LLC ("Oxford"), a specialty ... and healthcare services companies, today announced the closing of ... Inc. ("the Company"). Proceeds from the loan are being ... Company,s Rejuvaphyl™ and daily skincare products. ... brand of high potency skincare products that contain the ...
(Date:12/1/2015)... Dec. 01, 2015 ... of the "2016 Europe Cell Surface ... Technologies, Competitive Strategies, Opportunities for Suppliers--France, Germany, ... offering. --> ) has ... Europe Cell Surface Markers: Country Volume and ...
(Date:12/1/2015)... ... December 01, 2015 , ... Park Systems , ... add-on scanning ion conductance microscopy module to Park NX10 that is the only ... Park SICM benefits virtually all materials characterization that require measurements in liquid such ...
Breaking Biology Technology: