Navigation Links
Regulatory role of key molecule discovered at Hebrew U.
Date:9/17/2009

Jerusalem, Sept. 16, 2009 Discovery by Hebrew University of Jerusalem researchers of an additional role for a key molecule in our bodies provides a further step in world-wide efforts to develop genetic regulation aimed at controlling many diseases, including AIDS and various types of cancers.

The molecule, known as Lysyl-tRNA synthetase (or LysRS in brief) is one of the most ancient molecules in the cell, where it has long been recognized for its contribution in the translation of the information contained in RNA into the amino acids that make up proteins. Amino acids are organic compounds which are present in and vital to every living cell.

Now, the Hebrew University scientists have discovered that LysRS plays an important additional role as a central regulator controlling expression of various genes. In this additional role, LysRS ceases its previous function at a certain point and participates in a chain of events that causes the freeing of inhibitors that prevent expression of certain genes.

The researchers say that this research has particularly great importance, since LysRS is known to be involved in diseases such as AIDS and cancers. The virus HIV uses the host's cellular LysRS in the process of replication. High levels of LysRS also have been observed in certain cancers, such as breast cancer. The specific molecular mechanisms in these contexts remain to be discovered.

An ability to understand the regulatory effect played by LysRS in various diseases could make an important contribution to the worldwide search for therapies that would control the "turning on" or "turning off" of specific genes that are operative in those diseases, they emphasize.


'/>"/>

Contact: Jerry Barach
jerryb@savion.huji.ac.il
972-258-82904
The Hebrew University of Jerusalem
Source:Eurekalert  

Page: 1

Related biology news :

1. USC researchers identify regulatory genetic sequences that may predict risk for prostate cancer
2. Regulatory molecule for tumor formation or suppression identified by Singapore, US researchers
3. Food counterfeiting, contamination outpace international regulatory systems
4. New data suggest jumping genes play a significant role in gene regulatory networks
5. Caltech researchers help unlock the secrets of gene regulatory networks
6. New regulatory mechanism discovered for cell identify and behavior in forming organs
7. Use of nanomaterials in food packaging poses regulatory challenges
8. Type 1 diabetes triggered by lazy regulatory T-cells: McGill researchers
9. Small molecule inhibits pathology associated with myotonic dystrophy type 1
10. U-Iowa improves delivery of cancer-fighting molecules
11. Microbiologists find defense molecule that senses respiratory viruses
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Regulatory role of key molecule discovered at Hebrew U.
(Date:7/31/2014)... July 31, 2014 Biometrics industry ... innovative smart technologies; companies turn towards digital currency: NXT-ID, ... ), Amazon.com Inc. (NASDAQ: AMZN ), Facebook ... GOOG ) and Microsoft Corporation (NASDAQ: MSFT) ... on the growing m-commerce market, announces a video featuring ...
(Date:7/31/2014)... While previous studies have shown that marine noise can ... scientists from the Universities of Bristol and Exeter and ... France have demonstrated that boat noise stops embryonic development ... hares, (specifically the sea slug Stylocheilus striatus ... to swim away and later feed on toxic alga ...
(Date:7/30/2014)... New York University is paving the way for ... civilians and military troops exposed to poisonous chemicalsparticularly ... An article in the current issue of the ... detoxifying organophosphates, which are compounds commonly used in ... developed by NYU School of Engineering Associate Professor ...
Breaking Biology News(10 mins):Smart Technology Consumer's Interest in Mobile Payment Products Grows - Company Secures Deal with Major Airline to Display Advertisements in Flight for its Next Generation Smart Wallet 2Smart Technology Consumer's Interest in Mobile Payment Products Grows - Company Secures Deal with Major Airline to Display Advertisements in Flight for its Next Generation Smart Wallet 3Smart Technology Consumer's Interest in Mobile Payment Products Grows - Company Secures Deal with Major Airline to Display Advertisements in Flight for its Next Generation Smart Wallet 4Smart Technology Consumer's Interest in Mobile Payment Products Grows - Company Secures Deal with Major Airline to Display Advertisements in Flight for its Next Generation Smart Wallet 5Smart Technology Consumer's Interest in Mobile Payment Products Grows - Company Secures Deal with Major Airline to Display Advertisements in Flight for its Next Generation Smart Wallet 6Boat noise impacts development and survival of sea hares 2Engineering a protein to prevent brain damage from toxic agents 2
... April 19, 2010 Scientists from The Scripps Research ... how certain genetic mutations lead to Type 1 diabetes. This ... 1 diabetes and other autoimmune diseases. The study was ... of Clinical Investigation on April 19, 2010, and will ...
... of the Carnegie Institution,s Department of Global Ecology, is ... sciences, the humanities and the arts, business, public affairs, ... the new class of members of the American Academy ... world,s most prestigious honorary societies, cited Field for his ...
... BUFFALO, N.Y. -- A University at Buffalo volcanologist, an expert ... how the jet stream -- the area in the atmosphere ... be the area most likely to be impacted by plumes ... Bursik, PhD, one of the foremost experts on volcanic plumes ...
Cached Biology News:Scripps Research scientists reveal how genetic mutations may cause type 1 diabetes 2Scripps Research scientists reveal how genetic mutations may cause type 1 diabetes 3Carnegie's Chris Field elected to American Academy of Arts & Sciences 2Volcanic ash research shows how plumes end up in the jet stream 2
(Date:7/31/2014)... 31, 2014 According to a ... for Medical Devices Market (Diagnostic Electrodes - ECG, EEG, ... TENS, Pacemakers, Defibrillators, Electrosurgical and Other Electrodes) - Global ... - 2019," the global electrodes market for medical devices ... is estimated to reach a market worth USD 1,451.2 ...
(Date:7/31/2014)... Senomyx , Inc. (NASDAQ: ... taste science technologies to discover, develop, and commercialize ... ingredient supply industries, today reported financial results for ... second quarter with $33.6 million in cash and ... past quarter Senomyx achieved another important milestone with ...
(Date:7/31/2014)... San Francisco, Calif. (PRWEB) July 31, 2014 ... provides newly diagnosed patients with an overview of the ... the management of drug side effects, as well as ... , “We’re grateful to Dr. Sandy Srinivas for organizing ... 25-year survivor of kidney cancer. “Sandy and her colleagues ...
(Date:7/31/2014)... 31, 2014 Although RNA-Sequencing is ... first transcriptome-wide analyses appearing around 2008, RNA-Sequencing has ... RNA measurement. In the last several years, assays ... work with smaller input amounts, process degraded RNA, ... samples). On the bioinformatics side, there have been ...
Breaking Biology Technology:Electrodes for Medical Devices Market Expected to Reach USD 1.45 Billion Globally in 2019: Transparency Market Research 2Electrodes for Medical Devices Market Expected to Reach USD 1.45 Billion Globally in 2019: Transparency Market Research 3Electrodes for Medical Devices Market Expected to Reach USD 1.45 Billion Globally in 2019: Transparency Market Research 4Electrodes for Medical Devices Market Expected to Reach USD 1.45 Billion Globally in 2019: Transparency Market Research 5Electrodes for Medical Devices Market Expected to Reach USD 1.45 Billion Globally in 2019: Transparency Market Research 6SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 2SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 3SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 4SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 5SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 6SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 7SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 8SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 9SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 10SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 11SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 12SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 13SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 14SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 15SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 16The Evolution of RNA-Sequencing, Upcoming Live Webinar August 22 hosted by Xtalks 2
... ZyStor Therapeutics, Inc. will seek additional venture ... investigational new drug application, president and CEO Loren G. ... an informal gathering at the Innovation Monday program. He ... seek additional financing before filing the application for its ...
... solid revenue growth could not prevent Renaissance Learning, ... quarter of 2006, and as a result the company ... D. Paul said Tuesday. , ,Renaissance is a provider ... schools and districts. The company said net income, which ...
... Internet Protocol telephony gaining momentum in the private sector, ... Wisconsin product line of Norlight Telecommunications , the ... Cisco premise-based system, the Wisconsin-based voice and data provider ... vendor at a time when the telecommunications industry is ...
Cached Biology Technology:Milwaukee area biotech ZyStor seeks more funding 2Milwaukee area biotech ZyStor seeks more funding 3Renaissance earnings down 46 percent 2Norlight adds Cisco-based IP systems in Wisconsin 2
... White walled plates enhance luminescent signals ... fluorescence,• Not treated (or medium binding) ... and binds biomolecules through passive interactions,• ... of large molecules, such as antibodies, ...
...
... Columbus is a flexible, fully automated microplate strip ... to its fully automated microplate strip washing capability, ... and ease of operation. , ... include manifolds of 8, 12 or 16 channels, ...
... SBED Protein:Protein Interaction Reagent A powerful ... rapidly gained traction as an in vitro ... number of publications feature the exclusive Pierce ... study a variety of issues relating to ...
Biology Products: