Navigation Links
Regulation of telomerase in stem cells and cancer cells
Date:6/27/2012

This release is available in German.

Scientists at the Max Planck Institute of Immunobiology and Epigenetics in Freiburg have gained important insights for stem cell research which are also applicable to human tumours and could lead to the development of new treatments. As Rolf Kemler's research group discovered, a molecular link exists between the telomerase that determines the length of the telomeres and a signalling pathway known as the Wnt/β-signalling pathway.

Telomeres are the end caps of chromosomes that play a very important role in the stability of the genome. Telomeres in stem cells are long and become shorter during differentiation or with age, but lengthen again in tumour cells.

The Wnt/β-catenin signalling pathway controls numerous processes in embryonic development, such as the formation of the body axis and of organ primordia, and is particularly active in embryonic and adult stem cells. The β-catenin protein plays a key role in this signalling pathway. The incorrect regulation or mutation of β-catenin leads to the development of tumours.

Rolf Kemler's research group has now shown that β-catenin regulates the telomerase gene directly, and has explained the molecular mechanism at work here. Embryonic stem cells with mutated β-catenin generate more telomerase and have extended telomeres, while cells without β-catenin have low levels of telomerase and have shortened telomeres.

This regulation mechanism can also be found in human cancer cells. These discoveries could lead to the development of a new approach to the treatment of human tumours.


'/>"/>

Contact: Rolf Kemler
kemler@ie-freiburg.mpg.de
49-761-510-8471
Max-Planck-Gesellschaft
Source:Eurekalert

Page: 1

Related biology news :

1. BUSM study shows role of cellular protein in regulation of binge eating
2. Tortoise and the hare: New drug stops rushing cancer cells, slow and steady healthy cells unharmed
3. Stem cells can repair a damaged cornea
4. Scientists produce eye structures from human blood-derived stem cells
5. Study demonstrates cells can acquire new functions through transcriptional regulatory network
6. Epigenetic signatures direct the repair potential of reprogrammed cells
7. Researchers print live cells with a standard inkjet printer
8. Nanopills release drugs directly from the inside of cells
9. Protein jailbreak helps breast cancer cells live
10. Newly found protein helps cells build tissues
11. BU researchers derive purified lung and thyroid progenitors from embryonic stem cells
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/22/2014)... of captive black rhino reproduction in Europe highlights ... breeding programmes. , Researchers from Chester Zoo, The ... carried out a six-year study which encompassed 90% ... Katie Edwards led the research as part of ... says: "Although some black rhinoceros breed well in ...
(Date:8/22/2014)... 3β-Hydroxysteroid-Δ24 reductase (DHCR24) is a multifunctional ... reticulum and has neuroprotective and cholesterol-synthesizing ... apoptosis caused by amyloid β deposition. ... Liaoning University in China constructed two ... drive DHCR24 expression specifically in neuronal ...
(Date:8/22/2014)... Stanford, CAEveryone,s heard of the birds and the ... flowers that are being fertilized. The fertilization process ... extensive communication between the male and female reproductive ... Stanford, Regensburg, Heidelberg, and Munich, and including Carnegie,s ... discoveries in the chemical signaling process that guides ...
Breaking Biology News(10 mins):Hormone analysis helps identify horny rhinos 2Calcium and reproduction go together 2
... team of scientists led by University of Hawai,i at ... Florida International University, and Alexander Tielens of Leiden Observatory ... form polycyclic aromatic hydrocarbons (PAHs) complex organic molecules ... ultra-cold regions of interstellar space. The team announced their ...
... Rockville, MD The Association for Research in Vision ... Vision Science & Technology (TVST), with an open ... online only, peer-reviewed journal emphasizing multidisciplinary research that bridges ... The new journal will publish manuscripts in ...
... published online in the FASEB Journal ( http://www.fasebj.org ... the intestines may be used to predict a person,s likelihood ... may help reduce heart attack risk. This discovery may lead ... prevent and treat heart attacks. In addition, this research suggests ...
Cached Biology News:UH Manoa researchers discover novel chemical route to form organic molecules 2UH Manoa researchers discover novel chemical route to form organic molecules 3UH Manoa researchers discover novel chemical route to form organic molecules 4ARVO launches new journal on translational research 2The microbiome and disease: Gut bacteria influence the severity of heart attacks in rats 2
(Date:8/22/2014)... York (PRWEB) August 22, 2014 ... of the interesting and challenging endeavors as the ... highly impervious properties to the foreign substances. Ocular ... possibility of self medication and minimal use of ... molecular weight drugs and provides specific targeting within ...
(Date:8/22/2014)... Research and Markets has announced the addition ... Reagents (Cloning, Epigenetics, PCR, Restriction Digestion, Sequencing) Market - ... The global molecular biology enzymes market was ... to grow at a CAGR of 13.74% to reach ... reagents find applications in a large number of fields ...
(Date:8/22/2014)... Toronto, Canada (PRWEB) August 22, 2014 ... traits in model organisms can be accelerated by ... design and manufacturing technologies, the custom SeqCap EZ ... such research. , Mr. Watson will additionally present ... seen with commercially available human and mouse exome ...
(Date:8/21/2014)... 2014 DNA vaccine pioneer Immunomic ... development of JRC-LAMP-vax, an innovative and safe potential treatment ... studies began this month in Hawaii, moving the world ... The Japanese red cedar releases pollen that causes devastating ... Cedar pollen wreaks similar havoc in Colorado, New Mexico ...
Breaking Biology Technology:Ocular Drug Delivery Technologies Market: Global Industry Analysis, Size, Share, Growth, Trends and Forecast 2014 - 2020 2Ocular Drug Delivery Technologies Market: Global Industry Analysis, Size, Share, Growth, Trends and Forecast 2014 - 2020 3Ocular Drug Delivery Technologies Market: Global Industry Analysis, Size, Share, Growth, Trends and Forecast 2014 - 2020 4Global Molecular Biology Enzymes, Kits, & Reagents (Cloning, Epigenetics, PCR, Restriction Digestion, Sequencing) Market - Forecast to 2018 2Global Molecular Biology Enzymes, Kits, & Reagents (Cloning, Epigenetics, PCR, Restriction Digestion, Sequencing) Market - Forecast to 2018 3Efficient Identification of Protein-Coding Variants in a Model Organism Through Exome Sequencing, New Webinar Hosted by Xtalks 2Relief for Allergy Sufferers Finally in Sight: Immunomic Therapeutics Closes in on Treatment for Hay Fever in Japan, U.S. 2Relief for Allergy Sufferers Finally in Sight: Immunomic Therapeutics Closes in on Treatment for Hay Fever in Japan, U.S. 3Relief for Allergy Sufferers Finally in Sight: Immunomic Therapeutics Closes in on Treatment for Hay Fever in Japan, U.S. 4
... pure proteinTHOUSAND OAKS, Calif., Feb. 24 Bone Biologics, ... organization, Aragen Bioscience, has completed development of a recombinant ... recombinant protein. Bone Biologics has been developing the protein ... ten years of research in the lab performed by ...
... Genencor, a division of Danisco A/S, launched Accellerase(R) ... enzyme product. Genencor introduced the product at the ... in San Antonio, TX.Accellerase(R) 1500 is another significant ... made from cellulosic feedstocks, such as agricultural residues ...
... Ohio, Feb. 24 EyeScience Labs has launched ... comprehensive information and education on age-related macular degeneration (AMD) ... progressive, hereditary eye disease that is the leading cause ... the site, visitors can learn about basic eye anatomy, ...
Cached Biology Technology:Bone Biologics Announces UCB-1 (NELL-1) Bone Growth Protein Production Process With Aragen Biosciences 2Genencor Launches Accellerase(R) 1500, Next Step Toward Scale-Up of Cellulosic Ethanol 2EyeScience Launches Comprehensive Online Resource Devoted to Age-Related Macular Degeneration Education and Prevention 2
...
Phospho-4E-BP1 (Thr37/46) (236B4) Rabbit mAb Shipping Temperature: Cold Storage Temperature: -20C...
RNA polymerase sigma 70 Immunogen: Recombinant, full length protein. Storage: -20 C, Avoid Freeze/Thaw Cycles...
Rat monoclonal to UGGT ( Abpromise for all tested applications)....
Biology Products: