Navigation Links
Regulation of telomerase in stem cells and cancer cells
Date:6/27/2012

This release is available in German.

Scientists at the Max Planck Institute of Immunobiology and Epigenetics in Freiburg have gained important insights for stem cell research which are also applicable to human tumours and could lead to the development of new treatments. As Rolf Kemler's research group discovered, a molecular link exists between the telomerase that determines the length of the telomeres and a signalling pathway known as the Wnt/β-signalling pathway.

Telomeres are the end caps of chromosomes that play a very important role in the stability of the genome. Telomeres in stem cells are long and become shorter during differentiation or with age, but lengthen again in tumour cells.

The Wnt/β-catenin signalling pathway controls numerous processes in embryonic development, such as the formation of the body axis and of organ primordia, and is particularly active in embryonic and adult stem cells. The β-catenin protein plays a key role in this signalling pathway. The incorrect regulation or mutation of β-catenin leads to the development of tumours.

Rolf Kemler's research group has now shown that β-catenin regulates the telomerase gene directly, and has explained the molecular mechanism at work here. Embryonic stem cells with mutated β-catenin generate more telomerase and have extended telomeres, while cells without β-catenin have low levels of telomerase and have shortened telomeres.

This regulation mechanism can also be found in human cancer cells. These discoveries could lead to the development of a new approach to the treatment of human tumours.


'/>"/>

Contact: Rolf Kemler
kemler@ie-freiburg.mpg.de
49-761-510-8471
Max-Planck-Gesellschaft
Source:Eurekalert

Page: 1

Related biology news :

1. BUSM study shows role of cellular protein in regulation of binge eating
2. Tortoise and the hare: New drug stops rushing cancer cells, slow and steady healthy cells unharmed
3. Stem cells can repair a damaged cornea
4. Scientists produce eye structures from human blood-derived stem cells
5. Study demonstrates cells can acquire new functions through transcriptional regulatory network
6. Epigenetic signatures direct the repair potential of reprogrammed cells
7. Researchers print live cells with a standard inkjet printer
8. Nanopills release drugs directly from the inside of cells
9. Protein jailbreak helps breast cancer cells live
10. Newly found protein helps cells build tissues
11. BU researchers derive purified lung and thyroid progenitors from embryonic stem cells
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/23/2017)... PUNE, India , March 23, 2017 The report ... Equipment, Touchless Biometric), Industry, and Geography - Global Forecast to 2022", published by ... growing at a CAGR of 29.63% between 2017 and 2022. ... ... Logo ...
(Date:3/22/2017)... YORK , March 21, 2017 ... Marketing Cloud used by retailers such as 1-800-Flowers ... its platform — Product Recommendations and Replenishment. Using Optimove,s ... give more personalized product and replenishment recommendations to ... but also on predictions of customer intent drawn ...
(Date:3/20/2017)... PMD Healthcare announces the release of its ... System (WMS), a remote, real-time lung health monitoring and ... is a Medical Device, Digital Health, and Chronic Care ... innovative solutions that empower people to improve their healthcare ... developed the first ever personal spirometer, Spiro PD, which ...
Breaking Biology News(10 mins):
(Date:6/23/2017)... IA (PRWEB) , ... June 23, 2017 , ... Biova, ... Henig, Ph.D. has joined Biova’s Board of Directors. Dr. Henig will bring a wealth ... Dr. Henig has served as the Chief Technical and Scientific Officer of four major ...
(Date:6/23/2017)... ... June 23, 2017 , ... ... for all six of their healthcare job boards. As the largest network ... occupational therapists, and biotechnicians, DocCafe.com and the MedJobCafe.com Health Network work to ...
(Date:6/22/2017)... Colorado (PRWEB) , ... June 21, 2017 , ... ... RTP regional office in North Carolina, and engages Timothy Reinhardt to manage the ... of quality leadership at Pfizer Inc, with his most recent role as the ...
(Date:6/22/2017)... ... June 22, 2017 , ... Ovation Fertility ... as a disease, bringing new hope for prospective parents who are challenged with ... to back the World Health Organization’s designation in hopes of changing the way ...
Breaking Biology Technology: