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Regulation of cell proliferation is dependent on nucleocytoplasmic trafficking
Date:8/23/2010

oimmune diseases, and cancer."

Dr. Steve Goodman, Editor-in-Chief of Experimental Biology and Medicine stated "Ian Zagon and his colleagues are responsible for the describing the myriad of functions of the Opioid Growth Factor (OGF) and its receptor (OGFr) in health and disease. In this very interesting article, they have demonstrated the molecular mechanisms underlying nuclear import of OGF-OGFr. Specifically, they have demonstrated a role for karyopherin β and Ran in this process. The nuclear transport of OGF-OGFr is critical for the regulation of cell proliferation."


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Contact: Dr. Ian Zagon
isz1@psu.edu
717-531-8650
Society for Experimental Biology and Medicine
Source:Eurekalert

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