Navigation Links
Regulation of cell proliferation is dependent on nucleocytoplasmic trafficking
Date:8/23/2010

This release is also available in Chinese on EurekAlert! Chinese.

Researchers at The Pennsylvania State University College of Medicine, Hershey, Pennsylvania have discovered that the Opioid Growth Factor (OGF, [Met5]-enkephalin) and its receptor, OGFr, a clinically important system with potent antitumor properties, has controlled entry from the cytoplasm to the nucleus. The nucleocytoplasmic passage of OGF-OGFr is critical to cell proliferation and suggests that there are hierarchical levels of nuclear import. This discovery, reported in the September 2010 issue of Experimental Biology and Medicine, provides new insights into understanding the pathobiology of diseases related to this native biological system, and contributes to the development of new agents that will enhance treatment effectiveness.

Previous immunohistochemical and immunoelectron microscope studies have detected OGF and OGFr in both the cytoplasm and the nucleus. The OGF-OGFr axis is known to regulate cell proliferation by modulating cyclin dependent kinase inhibitors, resulting in a retardation of cells at the G1-S interface of the cell cycle. Experiments utilizing a human cancer cell line, a squamous cell carcinoma of the head and neck, and a probe of OGFr fused to green fluorescent protein (eGFP), revealed the presence of a transport factor, karyopherin β, which plays a key role in nucleocytoplasmic transport. Moreover, directionality of transport for karyopherin β is dependent on the small guanosine triphophatase (GTPase) Ran. Knockdown of karyopherin β or Ran with siRNAs, but not the adaptor molecule karyopherin α, prevented transport of OGFr-eGFP and resulted in a marked increase in DNA synthesis. These results document that the pathway for regulating the cell cycle by
'/>"/>

Contact: Dr. Ian Zagon
isz1@psu.edu
717-531-8650
Society for Experimental Biology and Medicine
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Mechanical regulation of cell substrates effects stem cell development, adhesion
2. Flemish researchers provide the first experimental evidence of dynamic allostery in protein regulation
3. Remote control for cholesterol regulation discovered in brain
4. New computational method to uncover gene regulation
5. New data on the regulation of a protein that is altered in all cancers
6. Rewiring of gene regulation across 300 million years of evolution
7. Gene regulation: Can we stomach it?
8. High-throughput analysis of gene regulation, DNA synthesis in Cold Spring Harbor Protocols
9. Linheng Li proposes novel theory for mammalian stem cell regulation
10. $1 million from NIH continues cell growth regulation studies
11. New research into the mechanisms of gene regulation
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/17/2014)... Domestication," a special feature of The ... PNAS ) published April 29, raises a number of ... that most of us take for granted. At the ... spots around the globe shifted from hunting animals and ... , It seems so straightforward and yet the more ...
(Date:4/16/2014)... ,, TALLAHASSEE, Fla. Florida State University researchers have ... the deterioration of bone density and muscle mass with ... the heavier you were the better your bones would ... Jasminka Ilich-Ernst, the Hazel Stiebeling Professor of Nutrition at ...
(Date:4/16/2014)... muscular atrophy (SBMA) is a rare inherited neuromuscular disorder characterized ... considered it to be essentially an affliction of primary motor ... that control muscle movement. , But in a new study ... Neuron , a team of scientists at the University of ...
Breaking Biology News(10 mins):Genetic study tackles mystery of slow plant domestications 2Genetic study tackles mystery of slow plant domestications 3Genetic study tackles mystery of slow plant domestications 4Researchers: Obesity can amplify bone and muscle loss 2Mutant protein in muscle linked to neuromuscular disorder 2
... move or speak, showed signs of attentive awareness that had ... was able to focus on words signalled by the experimenters ... ability can be developed consistently in certain patients who are ... the future and enable them to interact with the outside ...
... a queen bee, lots of female worker bees and some male ... much more complex than has been assumed up until now and ... rate. This is the finding of an international team of scientists ... Genetics of the University of Cologne. The study has been published ...
... team of international scientists has isolated a very close relative ... bats in China, confirming them as the origin of the ... 774 people of the 8094 people infected, a case fatality ... the world, the pandemic had an impact on international travel ...
Cached Biology News:Patient in 'vegetative state' not just aware, but paying attention 2Sex determiner gene of honey bee more complicated that previously assumed 2
(Date:1/15/2014)... VA (PRWEB) January 15, 2014 Two ... have continued their sponsorship of an annual competition for ... in, and access to, innovative STEM study. The competition ... TEAMS: Tests of Engineering Aptitude, Mathematics, and Sciences ...
(Date:1/15/2014)... Raleigh, NC (PRWEB) January 15, 2014 ... enhancement to its Online Web Portal for Life Science organizations ... ability to specify the subject matter of their documents in ... This will help reduce time-to-delivery of translations, often a critical ...
(Date:1/15/2014)... Freeslate, Inc ., the leading ... Lupin Limited, one of India’s top five pharmaceutical companies, ... System for high throughput solid form screening. ... a wide range of quality, affordable generic and branded ...
(Date:1/15/2014)... TAIPEI , Jan. 15, 2014 TaiGen Biotechnology ... an exclusive agreement with R-Pharm, a leading Russian pharmaceutical ... in the Russian Federation , ... Commonwealth Independent States (CIS). Nemonoxacin is a novel antibiotic for ...
Breaking Biology Technology:Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 2Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 3Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 4Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 5DTS Improves Efficiency for Life Science Document Translations 2Lupin Selects Freeslate’s CM Protégé PharmD System to Accelerate Polymorph Screening for Drug Development 2Lupin Selects Freeslate’s CM Protégé PharmD System to Accelerate Polymorph Screening for Drug Development 3TaiGen Biotechnology Signed Exclusive License Agreement with R-Pharm for Nemonoxacin (Taigexyn(R)) 2TaiGen Biotechnology Signed Exclusive License Agreement with R-Pharm for Nemonoxacin (Taigexyn(R)) 3TaiGen Biotechnology Signed Exclusive License Agreement with R-Pharm for Nemonoxacin (Taigexyn(R)) 4
... Wedgewood Pharmacy has,announced that it will continue ... ophthalmologists who request it for their patients.,The ... http://www.lucentis.com/lucentis/pdf/announcement.pdf ) to stop supplying,Avastin directly to ... Avastin is commonly administered by retinal specialists ...
... Test Offers Most Accurate Measurement of Women,s Ovarian ... ... (GRS),today announced it will be the first IVF center in the southeast ... assessment of a woman,s egg supply by combining multiple factors,including the measurement ...
... misrepresented the ... company to investors, ... a,proposed class-action lawsuit on behalf of CellCyte Genetics Corporation,(OTC Bulletin ... chief executive officer Gary A.,Reys, background, causing company stocks to ...
Cached Biology Technology:Wedgewood Pharmacy Will Continue to Provide Avastin(R) to Ophthalmologists and Retinal Specialists 2Wedgewood Pharmacy Will Continue to Provide Avastin(R) to Ophthalmologists and Retinal Specialists 3Georgia Reproductive Specialists is First in Southeast to Offer Pioneering Test of Women's Biological Clock 2Georgia Reproductive Specialists is First in Southeast to Offer Pioneering Test of Women's Biological Clock 3Hagens Berman Sobol Shapiro: Lawsuit Filed Against CellCyte Genetics Corporation 2Hagens Berman Sobol Shapiro: Lawsuit Filed Against CellCyte Genetics Corporation 3
Goat polyclonal to SART3 ( Abpromise for all tested applications). Antigen: Synthetic peptide: MSNADFAKLFLRK, corresponding to C terminal amino acids 951-963 of Human SART3 Entrez Gene ID: 9...
Hamartin/TSC1 (1B2) Mouse mAb Ship: Hot Store: -20 C...
synaptotagmin XIV-like [Source:RefSeq_peptide;Acc:NP_114120] Antigen: Recombinant Protein Epitope Signature Tag (PrEST)....
BDFastImmune? IFN-gamma /CD69/CD4/CD3 Storage Temperature: Refrigerate(2 to 8C)...
Biology Products: