Navigation Links
Regulation of TATA-less promoters
Date:11/1/2007

In their upcoming G&D paper, Dr. Robert Tjian (UC Berkeley) and colleagues reveal how histone gene expression is differentially regulated during Drosophila development. The researchers demonstrate that different basal transcription factors drive expression of the histone gene cluster, lending new insight into the regulation of metazoan transcription.

"This study surprised us on 2 levels; one was the preponderance of TRF2 dependent promoters; the other was the differential usage of TRF2 versus TBP within a gene cluster generally thought to be coordinately regulated. Just goes to show that dogma shifts constantly in this field of transcriptional control, explains Dr. Tjian.

In eukaryotic cells, gene transcription is initiated when the RNA polymerase II machinery recognizes and binds to specific core promoter sequences in the gene. While some genes contain a TATA box core promoter element that is recognized by TBP (the TATA-box binding polypeptide), the majority of core promoters fall into various TATA-less categories. A family of TBP-related factors (called TRFs) have been identified, but their core promoter recognition functions have not yet been elucidated.

In this paper, Dr. Tjian and colleagues identify novel TRF2 target promoters, effectively distinguishing between three classes of genes: TBP-dependent ones, TRF2-dependent ones and a small class genes that utilize both TBP and TRF2. They show that TRF2 is used as an alternative core promoter recognition factor to drive transcription of the TATA-less Histone H1 gene, while the other core Histone genes (H2A, H2B, H3 and H4) are dependent upon TBP. Furthermore, depletion of TRF2 in Drosophila cells resulted in reduced ribosomal gene transcription, abnormal cell changes and chromosomal defects.


'/>"/>

Contact: Heather Cosel
coselpie@cshl.edu
Cold Spring Harbor Laboratory
Source:Eurekalert

Page: 1

Related biology news :

1. New insight into regulation of blood stem cells
2. NYU, Rockefeller researchers find complexity of regulation by microRNA genes
3. MicroRNAs play a big part in gene regulation - and evolution
4. UCR chemist part of team identifying new areas of gene regulation
5. Bioinformatics reveals new gene regulation system
6. Researchers appeal for new regulations to save coral reefs from live fish trade
7. Novel enzyme offers new look at gene regulation
8. Researchers discover new form of cancer gene regulation
9. K-State researchers study gene regulation in insects
10. Most human-chimp differences due to gene regulation ?not genes
11. Cells use mix-and-match approach to tailor regulation of genes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/13/2017)... 13, 2017 UBM,s Advanced Design and Manufacturing ... feature emerging and evolving technology through its 3D Printing ... run alongside the expo portion of the event and ... demonstrations focused on trending topics within 3D printing and ... manufacturing event will take place June 13-15, 2017 at the ...
(Date:4/11/2017)... MELBOURNE, Florida , April 11, 2017 ... "Company"), a security technology company, announces the appointment of independent ... John Bendheim to its Board of Directors, furthering the ... ... behalf of NXT-ID, we look forward to their guidance and ...
(Date:4/4/2017)... , April 4, 2017   EyeLock LLC ... announced that the United States Patent and Trademark Office ... broadly covers the linking of an iris image with ... transaction) and represents the company,s 45 th issued ... patent is very timely given the multi-modal biometric capabilities ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... ... October 11, 2017 , ... Disappearing forests and increased ... of over 5.5 million people each year. Especially those living in larger cities are ... - based in one of the most pollution-affected countries globally - decided to take ...
(Date:10/11/2017)... Tampa Bay, Florida (PRWEB) , ... October 11, ... ... Food and Drug Administration (FDA) has granted orphan drug designation to SBT-100, its ... antibody (sdAb) for the treatment of osteosarcoma. SBT-100 is able to cross the ...
(Date:10/10/2017)... , ... October 10, 2017 ... ... cancer-focused pharmaceutical company advancing targeted antibody-drug conjugate (ADC) therapeutics, today confirmed licensing ... HPLN (Hybrid Polymerized Liposomal Nanoparticle), a technology developed in collaboration with Children’s ...
(Date:10/10/2017)... (PRWEB) , ... October 10, 2017 , ... Dr. Bob ... at his local San Diego Rotary Club. The event entitled “Stem ... CA and had 300+ attendees. Dr. Harman, DVM, MPVM was joined by two ...
Breaking Biology Technology: