Navigation Links
Regulation of TATA-less promoters
Date:11/1/2007

In their upcoming G&D paper, Dr. Robert Tjian (UC Berkeley) and colleagues reveal how histone gene expression is differentially regulated during Drosophila development. The researchers demonstrate that different basal transcription factors drive expression of the histone gene cluster, lending new insight into the regulation of metazoan transcription.

"This study surprised us on 2 levels; one was the preponderance of TRF2 dependent promoters; the other was the differential usage of TRF2 versus TBP within a gene cluster generally thought to be coordinately regulated. Just goes to show that dogma shifts constantly in this field of transcriptional control, explains Dr. Tjian.

In eukaryotic cells, gene transcription is initiated when the RNA polymerase II machinery recognizes and binds to specific core promoter sequences in the gene. While some genes contain a TATA box core promoter element that is recognized by TBP (the TATA-box binding polypeptide), the majority of core promoters fall into various TATA-less categories. A family of TBP-related factors (called TRFs) have been identified, but their core promoter recognition functions have not yet been elucidated.

In this paper, Dr. Tjian and colleagues identify novel TRF2 target promoters, effectively distinguishing between three classes of genes: TBP-dependent ones, TRF2-dependent ones and a small class genes that utilize both TBP and TRF2. They show that TRF2 is used as an alternative core promoter recognition factor to drive transcription of the TATA-less Histone H1 gene, while the other core Histone genes (H2A, H2B, H3 and H4) are dependent upon TBP. Furthermore, depletion of TRF2 in Drosophila cells resulted in reduced ribosomal gene transcription, abnormal cell changes and chromosomal defects.


'/>"/>

Contact: Heather Cosel
coselpie@cshl.edu
Cold Spring Harbor Laboratory
Source:Eurekalert

Page: 1

Related biology news :

1. New insight into regulation of blood stem cells
2. NYU, Rockefeller researchers find complexity of regulation by microRNA genes
3. MicroRNAs play a big part in gene regulation - and evolution
4. UCR chemist part of team identifying new areas of gene regulation
5. Bioinformatics reveals new gene regulation system
6. Researchers appeal for new regulations to save coral reefs from live fish trade
7. Novel enzyme offers new look at gene regulation
8. Researchers discover new form of cancer gene regulation
9. K-State researchers study gene regulation in insects
10. Most human-chimp differences due to gene regulation ?not genes
11. Cells use mix-and-match approach to tailor regulation of genes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/2/2016)... Feb. 2, 2016 Technology Enhancements Accelerate Growth of ... of the digital and computed radiography markets in ... and Indonesia (TIM). It provides ... size, as well as regional market drivers and restraints. ... market penetration and market attractiveness, both for digital and ...
(Date:2/1/2016)... 2016  Today, the first day of American Heart ... develop a first of its kind workplace health solution ... In the first application of Watson ... ), and Welltok will create a new offering that ... analytics, delivered on Welltok,s health optimization platform. The effort ...
(Date:1/25/2016)... BLUE BELL, Pa. , Jan. 25, 2016   Unisys ... facial recognition system at John F. Kennedy (JFK) International Airport, ... and Border Protection (CBP) identify imposters attempting to enter ... or do not belong to them. pilot testing ... rolled out initially at three terminals at JFK during January 2016. ...
Breaking Biology News(10 mins):
(Date:2/8/2016)... -- NanoViricides, Inc. (NYSE MKT: NNVC) (the "Company"), a nanomedicine company developing ... MPH, will present information about the company,s programs at the BIOCEO ... New York City . --> ... 5:30PM EST. Registered attendees can request a one on one meeting ... --> New York City . ...
(Date:2/6/2016)... Virginia (PRWEB) , ... February 06, 2016 , ... ... E-mail: amitchell(at)cee(dot)org , The Center for Excellence in Education Sponsors Teacher Training ... VA – February 4, 2016 – The Center for Excellence in Education (CEE) ...
(Date:2/5/2016)... drug discovery and development company, Novogen Limited (ASX:NRT; NASDAQ: ... Mr John O,Connor , and new Deputy Chairman, Mr ... Garner , has also been formally appointed to the Board ... Iain Ross , will resume his role on the Board ... has also been formally appointed to the Board as an ...
(Date:2/4/2016)... (PRWEB) , ... February 04, ... ... conference presented by Bloomsburg University’s Digital Forensics Club, takes place February 5-6 ... two-day event features 20+ speakers and activities such as workshops and competitions ...
Breaking Biology Technology: