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Regular aerobic exercise is good for the brain, Pitt team says
Date:4/26/2010

five days per week until week 24. In a preliminary task, the monkeys learned that by lifting a cover off a small well in the testing tray, they could have the food reward that lay within it. In a spatial delay task, a researcher placed a food reward in one of two wells and covered both wells in full view of the monkey. A screen was lowered to block the animal's view for a second, and then raised again. If the monkey displaced the correct cover, she got the treat. After reliably succeeding at this task, monkeys that correctly moved the designated one of two different objects placed over side-by-side wells got the food reward that lay within it.

"Monkeys that exercised learned to remove the well covers twice as quickly as control animals," Dr. Cameron said. "Also, they were more engaged in the tasks and made more attempts to get the rewards, but they also made more mistakes."

She noted that later in the testing period, learning rate and performance was similar among the groups, which could mean that practice at the task will eventually overshadow the impact of exercise on cognitive function.

When the researchers examined tissue samples from the brain's motor cortex, they found that mature monkeys that ran had greater vascular volume than middle-aged runners or sedentary animals. But those blood flow changes reversed in monkeys that were sedentary after exercising for five months.

"These findings indicate that aerobic exercise at the recommended levels can have meaningful, beneficial effects on the brain," Dr. Cameron said. "It supports the notion that working out is good for people in many, many ways."

Researchers from the Pitt's departments of psychiatry, neuroscience, and anthropology, as well as Korea University College of Medicine, University of Illinois, and Pennsylvania State University also authored the paper, which was supported by grants from the National Institute of Aging, the National Institute on Diabetes, Dig
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Contact: Anita Srikameswaran
SrikamAV@upmc.edu
412-578-9193
University of Pittsburgh Schools of the Health Sciences
Source:Eurekalert

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