Navigation Links
Regular aerobic exercise is good for the brain, Pitt team says

PITTSBURGH, April 26 Regular exercise speeds learning and improves blood flow to the brain, according to a new study led by researchers from the University of Pittsburgh School of Medicine that is the first to examine these relationships in a non-human primate model. The findings are available in the journal Neuroscience.

While there is ample evidence of the beneficial effects of exercise on cognition in other animal models, such as the rat, it has been unclear whether the same holds true for people, said senior author Judy L. Cameron, Ph.D., a psychiatry professor at Pitt School of Medicine and a senior scientist at the Oregon National Primate Research Center at Oregon Health and Science University. Testing the hypothesis in monkeys can provide information that is more comparable to human physiology.

"We found that monkeys who exercised regularly at an intensity that would improve fitness in middle-aged people learned to do tests of cognitive function faster and had greater blood volume in the brain's motor cortex than their sedentary counterparts," Dr. Cameron said. "This suggests people who exercise are getting similar benefits."

For the study, the researchers trained adult female cynomolgus monkeys to run on a human-sized treadmill at 80 percent of their individual maximal aerobic capacity for one hour each day, five days per week, for five months. Another group of monkeys remained sedentary, meaning they sat on the immobile treadmill, for a comparable time. Half of the runners went through a three-month sedentary period after the exercise period. In all groups, half of the monkeys were middle aged (10 to 12 years old) and the others were more mature (15 to 17 years old). Initially, the middle-aged monkeys were in better shape than their older counterparts, but with exercise, all the runners became more fit.

During the fifth week of exercise training, standardized cognitive testing was initiated and then performed five days per week until week 24. In a preliminary task, the monkeys learned that by lifting a cover off a small well in the testing tray, they could have the food reward that lay within it. In a spatial delay task, a researcher placed a food reward in one of two wells and covered both wells in full view of the monkey. A screen was lowered to block the animal's view for a second, and then raised again. If the monkey displaced the correct cover, she got the treat. After reliably succeeding at this task, monkeys that correctly moved the designated one of two different objects placed over side-by-side wells got the food reward that lay within it.

"Monkeys that exercised learned to remove the well covers twice as quickly as control animals," Dr. Cameron said. "Also, they were more engaged in the tasks and made more attempts to get the rewards, but they also made more mistakes."

She noted that later in the testing period, learning rate and performance was similar among the groups, which could mean that practice at the task will eventually overshadow the impact of exercise on cognitive function.

When the researchers examined tissue samples from the brain's motor cortex, they found that mature monkeys that ran had greater vascular volume than middle-aged runners or sedentary animals. But those blood flow changes reversed in monkeys that were sedentary after exercising for five months.

"These findings indicate that aerobic exercise at the recommended levels can have meaningful, beneficial effects on the brain," Dr. Cameron said. "It supports the notion that working out is good for people in many, many ways."

Researchers from the Pitt's departments of psychiatry, neuroscience, and anthropology, as well as Korea University College of Medicine, University of Illinois, and Pennsylvania State University also authored the paper, which was supported by grants from the National Institute of Aging, the National Institute on Diabetes, Digestive and Kidney Disorders, and the Retirement Research Foundation.


Contact: Anita Srikameswaran
University of Pittsburgh Schools of the Health Sciences

Related biology news :

1. JDRF-funded studies show regular CGM use increases diabetes control for all age groups
2. Genetic irregularities linked to higher risk of COPD among smokers
3. Regular family meals result in better eating habits for adolescents
4. U of M research finds disordered eating less common among teen girls who regularly eat family meals
5. Wild chimpanzees appear not to regularly experience menopause
6. Exercise therapy for low back pain
7. For osteoporosis patients, exercise pill one step closer to reality
8. Mental health providers should prescribe exercise more often for depression, anxiety
9. The new exercise HIT: do less
10. Exercise counters negative effects of weight regain, researchers find
11. What you eat after exercise matters
Post Your Comments:
(Date:10/29/2015)... Oct. 29, 2015  Connected health pioneer, Joseph ... explosion of technology-enabled health and wellness, and the business ... The Internet of Healthy Things . ... smartphones even existed, Dr. Kvedar, vice president, Connected Health, ... care delivery, moving care from the hospital or doctor,s ...
(Date:10/27/2015)... 2015 In the present market scenario, security ... various industry verticals such as banking, healthcare, defense, electronic ... demand for secure & simplified access control and growing ... hacking of bank accounts, misuse of users, , and ... PC,s, laptops, and smartphones are expected to provide potential ...
(Date:10/26/2015)... , October 26, 2015 /PRNewswire/ ... --> adds Biometrics ... to 2021 as well as Emerging ... research reports to its collection of ... . --> ...
Breaking Biology News(10 mins):
(Date:11/25/2015)... and HOLLISTON, Mass. , Nov. 25, ... HART ), a biotechnology company developing bioengineered organ ... Jim McGorry will present at the LD Micro ... at 2:30 p.m. PT. The presentation will be webcast ... days. Management will also be available at the conference ...
(Date:11/25/2015)... PORTLAND, Oregon , November 25, 2015 /PRNewswire/ ... Deep Market Research Report is a professional and ... Genomics industry.      (Logo: ... basic overview of the industry including definitions, classifications, ... analysis is provided for the international markets including ...
(Date:11/24/2015)... Halozyme Therapeutics, Inc. (NASDAQ: HALO ) will be presenting at ... on Wednesday, December 2 at 9:30 a.m. ET/6:30 a.m. PT ... provide a corporate overview. th Annual Oppenheimer Healthcare ... ET/10:00 a.m. PT . Jim Mazzola , vice president ... --> th Annual Oppenheimer Healthcare Conference in ...
(Date:11/24/2015)...  Clintrax Global, Inc., a worldwide provider of clinical research services ... that the company has set a new quarterly earnings record in ... growth posted for Q3 of 2014 to Q3 of 2015.   ... , with the establishment of an Asia-Pacific ... United Kingdom and Mexico , ...
Breaking Biology Technology: