Navigation Links
Regrowing blood vessels with a potent molecule
Date:8/2/2011

PITTSBURGHEver since the Nobel Prize for nerve growth factor was awarded more than 30 years ago, researchers have been searching for ways to use growth factor clinically.

University of Pittsburgh Professor Yadong Wang has developed a minimally invasive method of delivering growth factor to regrow blood vessels. His research, which could be used to treat heart disease, the most common cause of death in the Western world, is published this week in the Aug. 1 issue of the journal Proceedings of the National Academy of Sciences.

Wang is a professor in the Department of Bioengineering in Pitt's Swanson School of Engineering and the Department of Surgery in the University's School of Medicine. He is also affiliated with the Pitt-UPMC McGowan Institute of Regenerative Medicine (MIRM). His coauthors are Johnny Huard, professor in the Department of Bioengineering and the School of Medicine's Departments of Orthopaedic Surgery, Molecular Genetics, and Pathology, as well as MIRM; graduate student Hunghao Chu and postdoctoral fellow Jin Gao in the Departments of Bioengineering and Surgery; and Chien-Wen Chen, a Ph.D. candidate in bioengineering and surgery.

When the researchers injected their growth factor compound under the skin of mice, they saw something amazing: New blood vessels grew, and large ones, not just tiny capillaries. "We had structures that resembled arteriolessmall arteries that lead to a network of capillaries," says Wang.

Moreover, the structures stuck around. At least a month later, after only one injection of the growth factor complex, the new blood vessels were still there.

POWERFUL IN SMALL DOSES

In our bodies, growth factors control many different functions, including cell proliferation, migration, and differentiation. There are even growth factors that inhibit growth of certain cell types or cause cell suicide. "They are very potent molecules," says Wang.

Being so powerfu
'/>"/>

Contact: Karen Hoffmann
hoffkar@pitt.edu
412-444-5946
University of Pittsburgh
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. Scientist plans to test for blood pressure genes affected by age
2. Discovery of natural compounds that could slow blood vessel growth
3. New blood test for Down syndrome
4. On the trail of a targeted therapy for blood cancers
5. Lower your blood pressure, hydrate your skin and reduce dental plaque -- with chocolate?
6. Building the blood-brain barrier
7. Apelin hormone injections powerfully lower blood sugar
8. Battling bacteria in the blood: Researchers tackle deadly infections
9. Femtomolar optical tweezers may enable sensitive blood tests
10. Drops in blood oxygen levels may be key to sudden death in some epilepsy patients
11. Scripps research scientists identify blood component that turns bacteria virulent
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/18/2014)... their colleagues have built the first smartphone app ... and behavioral trends. In other words, your smartphone ... you don,t -- and how that affects you. ... stress, depression and loneliness to their academic performance, ... for example, to monitor mental health, trigger ...
(Date:9/18/2014)... which have devastated algal forests in the eastern Mediterranean ... basin if their distribution continues to expand as the ... an international team of researchers led by Dr Adriana ... the Mediterranean Institute for Advanced Studies in Spain, is ... of the team surveyed more than 1000 kilometres of ...
(Date:9/18/2014)... Becoming invisible is probably the ultimate form of camouflage: ... you. And this strategy is not as uncommon as ... Maryland Baltimore County, USA, explains that the larval life ... is one part of the anatomy that most creatures ... compound eyes have to shield each individual eye unit ...
Breaking Biology News(10 mins):New Dartmouth smartphone app reveals users' mental health, performance, behavior 2New Dartmouth smartphone app reveals users' mental health, performance, behavior 3New Dartmouth smartphone app reveals users' mental health, performance, behavior 4Tropical fish a threat to Mediterranean Sea ecosystems 2Transparent larvae hide opaque eyes behind reflections 2
... COLUMBUS, Ohio - For the first time, researchers have found ... therapy agent directly into a single living cell without a ... therapeutic biomolecules through a tiny channel and into a cell ... and his colleagues at Ohio State University describe the technique ...
... terrorized its plant-eating neighbours in South America was a lot ... found. Carnotaurus was a seven-metre-long predator with ... student Scott Persons says made it one of the fastest ... tail bones of Carnotaurus showed its caudofemoralis muscle ...
... , New York, NY (October 14, 2011) Researchers at ... uncovered a vast new gene regulatory network in mammalian cells ... The studies appear in today,s online edition of Cell ... a missing piece in the puzzle of cell regulation and ...
Cached Biology News:Researchers do precise gene therapy without a needle 2Researchers do precise gene therapy without a needle 3Vast hidden network regulates gene expression in cancer 2Vast hidden network regulates gene expression in cancer 3
(Date:9/18/2014)... D.C. (PRWEB) September 18, 2014 On ... Durbin and Sen. Jim Risch for National Lab Day ... projects from across the national laboratory system. Durbin and ... which aims to increase awareness of the reach of ... technologies and discoveries to address some of our nation's ...
(Date:9/18/2014)... Research and Markets has announced ... Report 2014" report to their offering. ... a professional and in-depth study on the current state ... report provides a basic overview of the industry including ... albumin market analysis is provided for the international markets ...
(Date:9/18/2014)...  U.S. biotech company Kultevat has strengthened ... technology developed by the Donald Danforth Plant Science ... for applications in production of natural rubber in ... developed under the direction of Roger Beachy , ... of the Danforth Plant Science Center, and is used ...
(Date:9/18/2014)... SEATTLE , Sept. 18, 2014 /PRNewswire/ - Oncothyreon ... pricing of previously announced concurrent but separate underwritten offerings ... price to the public of $2.00 per share, for ... of its Series A Convertible Preferred Stock at a ... expected gross proceeds of $20 million. Each share of ...
Breaking Biology Technology:Lab Day Highlight Labs' Contribution to U.S. Competitiveness and Innovation 2Lab Day Highlight Labs' Contribution to U.S. Competitiveness and Innovation 3Global Human Albumin Industry Report 2014 2Global Human Albumin Industry Report 2014 3Kultevat obtains license of gene switch technology 2Oncothyreon Prices $40 Million Concurrent Public Offerings of Common Stock and Preferred Stock 2Oncothyreon Prices $40 Million Concurrent Public Offerings of Common Stock and Preferred Stock 3
... 11 /PRNewswire-FirstCall/ - GeneNews Limited (TSX: GEN), a ... the early detection of diseases and personalized health ... a agreement allowing Centocor Research & Development, Inc. ... biomarker program. Additional terms of the agreement were ...
... Hovione announced today,that it has agreed with Pfizer to ... This site manufactures,intermediates for Lipitor active pharmaceutical ingredient. , ... had a number of owners starting in 1984 with ... and now Hovione. Over,the last 10 years Pfizer has ...
... McCulley/Cuppan announced today the launch of a new series of web-based ... The web delivered "short" courses are one hour in duration and ... writing skills. , ... Salt Lake City, Utah (PRWEB) ...
Cached Biology Technology:GeneNews provides Centocor access to its osteoarthritis program 2Hovione Buys Pfizer's Loughbeg API Facility 2Hovione Buys Pfizer's Loughbeg API Facility 3McCulley/Cuppan Announced Today The Launch Of A New Series Of Web-Based Training Programs For Professionals In The Biopharmaceutical And Life Science Industries 2McCulley/Cuppan Announced Today The Launch Of A New Series Of Web-Based Training Programs For Professionals In The Biopharmaceutical And Life Science Industries 3
...
Agarose for baculovirus plaque assays which allow optimal growth of plated insect cells....
BD BaculoGold Max-XP Insect Cell Medium 1 Liter...
Mycoplasma and virus tested...
Biology Products: