Navigation Links
Regenerating orthopedic tissues within the human body
Date:2/18/2014

nto the scaffolding, and once it's released, it's all gone. We need a method for long-term delivery of growth factors, and that's where the gene therapy comes in."

For ideas on how to solve this problem, Guilak turned to his colleague Charles Gersbach, an assistant professor of biomedical engineering and an expert in gene therapy. Gersbach proposed introducing new genes into the stem cells so that they produce the necessary growth factors themselves.

But the conventional methods for gene therapy are complex and difficult to translate into a strategy that would be feasible as a commercial product.

This type of gene therapy generally requires gathering stem cells, modifying them with a virus that transfers the new genes, culturing the resulting genetically altered stem cells until they reach a critical mass, applying them to the synthetic cartilage scaffolding and, finally, implanting it into the body.

"There are a few challenges with that process, one of them being that there are way too many extra steps," said Gersbach. "So we turned to a technique I had previously developed that affixes the viruses that deliver the new genes onto a material's surface."

The new study uses Gersbach's technique -- dubbed biomaterial-mediated gene delivery -- to induce the stem cells placed on Guilak's synthetic cartilage scaffolding to produce growth factor proteins. The results show that the technique works and that the resulting composite material is at least as good biochemically and biomechanically as if the growth factors were introduced in the laboratory.

"We want the new cartilage to form in and around the synthetic scaffold at a rate that can match or exceed the scaffold's degradation," said Jonathan Brunger, a graduate student who has spent time in both Guilak's and Gersbach's laboratories developing and testing the new technique. "So while the stem cells are making new tissue (in the body), the scaffold can withstand the
'/>"/>

Contact: Ken Kingery
ken.kingery@duke.edu
919-660-8414
Duke University
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Potential new approach to regenerating skeletal muscle tissue
2. Regenerating heart tissue topic of UH lecture Nov. 27
3. A step forward in regenerating and repairing damaged nerve cells
4. Research pinpoints key gene for regenerating cells after heart attack
5. Newly found protein helps cells build tissues
6. Make or break for cellular tissues
7. Penn researchers improve living tissues with 3-D printed vascular networks made from sugar
8. Why do organisms build tissues they seemingly never use?
9. Researchers develop method to grow artificial tissues with embedded nanoscale sensors
10. Tiny probes shine brightly to reveal the location of targeted tissues
11. Long-distance solute transport in trees improved by intercellular pathways in living woody tissues
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Regenerating orthopedic tissues within the human body
(Date:4/17/2014)... University of Texas Medical Branch at Galveston are ... with radiation for cervical cancer should begin colorectal ... The UTMB researchers, finding a high incidence of ... with radiation, offer new recommendations that the younger ... about eight years after their initial cervical cancer ...
(Date:4/17/2014)... Scientists have uncovered a new way the immune system ... aid efforts to use immune cells to treat illness. ... have the immunological equivalent of "neighborhood police" specialized ... single organ, instead of an entire city, the body. ... St. Louis have shown that the liver, skin and ...
(Date:4/17/2014)... of The Proceedings of the National ... 29, raises a number of startling questions about a ... take for granted. At the end of the last ... shifted from hunting animals and gathering fruits and tubers ... straightforward and yet the more scientists learn, the more ...
Breaking Biology News(10 mins):Radiation therapy for cervical cancer increases risk for colorectal cancer 2Some immune cells defend only 1 organ 2Genetic study tackles mystery of slow plant domestications 2Genetic study tackles mystery of slow plant domestications 3Genetic study tackles mystery of slow plant domestications 4
... PUYALLUP, Wash.A Washington State University toxicologist has found ... butterfly populations., The research was aimed at possible ... in northern California, but it has implications for ... used, says John Stark, an ecotoxicologist and director ...
... ago, marine scientists made a startling discovery in the deep ... water surges from the seafloor and life thrives without sunlight. ... areas where methane rises from seeps on the ocean bottom. ... living side-by-side? No one thought so. Until now. ...
... , The National Institute of Standards and Technology (NIST) ... the federal government,s Natural Resources Damage Assessment (NRDA) in ... spill 40 miles off the Louisiana coast. The new ... 2779), will be used as a quality control material ...
Cached Biology News:Commonly used herbicides seen as threat to endangered butterflies 2Hot meets cold at new deep-sea ecosystem: 'Hydrothermal seep' 2NIST releases Gulf of Mexico crude oil reference material 2
(Date:1/14/2014)... Communications, a leading provider of strategic communications services to corporations and ... the United States and Europe ... JD, is returning to the firm,s Washington, D.C. ... more than two years of service as Associate Commissioner for the ...
(Date:1/14/2014)... , Jan. 14, 2014 The largest international ... medicinal plants and therapeutic derivatives thereof has endorsed ... and researchers about the challenges of adulterated herb ... ) The Society for Medicinal ...
(Date:1/14/2014)... Canada (PRWEB) January 14, 2014 In ... its motives and methods in product development and promotion ... the industry. This mistrust, fueled by concerns about the ... fed by reports of spectacular fines to the world’s ...
(Date:1/14/2014)... Kinaxis ®, provider of RapidResponse ®, a cloud-based supply ... ( S&OP ) service, is proud to be a gold ... held at the Hilton San Diego Bayfront, January 30 – ... Kaszas , Director of Supply Chain at Amgen, as she ...
Breaking Biology Technology:Former FDA Associate Commissioner Returns To 3D Communications 2World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 2World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 3World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 4World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 5World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 6World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 7World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 8The Sunshine Act: Necessary Regulation or Unnecessary Dysregulation? New Life Science Webinar Hosted by Xtalks and IRB Services 2The Sunshine Act: Necessary Regulation or Unnecessary Dysregulation? New Life Science Webinar Hosted by Xtalks and IRB Services 3Event Alert: Kinaxis Customer to Present at the Biomanufacturing Summit "Supply Chain: Improving Network Effectiveness" 2
... news for the global effort to reduce the amount of ... technologies that rely upon the piezoelectric effect. A lead-free alternative ... by researchers with the U.S. Department of Energy,s Lawrence Berkeley ... Berkeley. The key to this success is the use ...
... TAI,AN CITY, China, Nov. 13 ... ("China Biologic," or the "Company"),one of the leading plasma-based ... host a conference call at 8:00 a.m. ET on,Monday, ... financial results,ended on September 30, 2009. , ...
... Soligenix, Inc., (Soligenix or the Company) (OTC ... Inc., a late-stage biotechnology company, announced today its ... , Highlights and Recent Developments: ... confirmatory Phase 3 randomized, double-blind, placebo-controlled, multicenter clinical ...
Cached Biology Technology:Berkeley researchers take the lead out of piezoelectrics 2Berkeley researchers take the lead out of piezoelectrics 3China Biologic Schedules Conference Call to Discuss Third Quarter 2009 Financial Results 2Soligenix Reports Third Quarter 2009 Financial Results 2Soligenix Reports Third Quarter 2009 Financial Results 3Soligenix Reports Third Quarter 2009 Financial Results 4Soligenix Reports Third Quarter 2009 Financial Results 5
... Panels were designed for full-length gene cloning ... to identify the desired cDNA clone. The ... 96-well "Master Plate," where each well contains ... the positive well(s) by gel electrophoresis of ...
... The CEQ 8800 Genetic Analysis System, which ... This automated system adds a higher level ... The CEQ 8800, part of Beckman Coulters new ... coding link with the Biomek series liquid handers, ...
... cDNA Library Panels were designed for full-length ... of PCRs to identify the desired cDNA ... in a 96-well "Master Plate," where each ... Having identified the positive well(s) by gel ...
... cDNA Library Panels were designed for full-length ... of PCRs to identify the desired cDNA ... in a 96-well "Master Plate," where each ... Having identified the positive well(s) by gel ...
Biology Products: