Navigation Links
Redundant genetic instructions in 'junk DNA' support healthy development
Date:7/16/2010

Seemingly redundant portions of the fruit fly genome may not be so redundant after all.

New findings from a Princeton-led team of researchers suggest that repeated instructional regions in the flies' DNA may contribute to normal development under less-than-ideal growth conditions by making sure that genes are turned on and off at the appropriate times. If similar regions are found in humans, they may hold important clues to understanding developmental disorders.

The research results, published in the July 22 issue of the journal Nature, add to the growing body of evidence that so-called "junk DNA" is anything but rubbish. The term "junk DNA" is commonly used to describe the portion of the genome that doesn't contain genes, which are pieces of DNA that code for the production of proteins and other molecules that have specific functions. The noncoding region is often surprisingly large; in humans, some 98 percent of the genome merits "junk" status. But according to David Stern, a Princeton professor in the Department of Ecology and Evolutionary Biology, scientists increasingly believe "junk DNA" is crucial for turning the information encoded in genes into useful products.

"Over the past 10 to 20 years, research has shown that instructional regions outside the protein-coding region are important for regulating when genes are turned on and off," said Stern, the senior scientist on the paper. "Now we're finding that additional copies of these genetic instructions are important for maintaining stable gene function even in a variable environment, so that genes produce the right output for organisms to develop normally."

Stern, along with Nicols Frankel, a postdoctoral research fellow at Princeton, and their collaborators focused their attention on instructional regions called enhancers. These regions play an important role in the process by which information encoded in genes is used to direct the synthesis of the proteins t
'/>"/>

Contact: Kitta MacPherson
kittamac@princeton.edu
609-258-5729
Princeton University
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. Genetically reprogrammed HSV given systemically shrinks distant sarcomas
2. Genetic code 2.0
3. UK geneticists shed light on flowering plants
4. International study identifies 12 new genetic risk factors for type 2 diabetes
5. TGen-led studies identify genetic links to kidney disease, kidney failure
6. Genetics in bloom
7. How genetic chips could help to understand heart disease
8. Genetic septet in control of blood platelet clotting
9. Genetically modified cell procedure may prove useful in treating kidney failure
10. Freely available data supporting next generation of human genetic research
11. Should the results of individual genetic studies be disclosed to participants?
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/17/2014)... Dec. 15, 2014 The Defense Logistics Agency is ... and prevent counterfeit microcircuits from entering into its supply ... in-house microcircuit anti-counterfeit initiative dubbed DNA marking. The capability ... their reliability throughout the supply chain. The new quality ...
(Date:12/17/2014)... and Markets ( http://www.researchandmarkets.com/research/9zq33j/global_chemical ) has announced ... 2015-2019" report to their offering. ... upcoming in this market is the increasing demand for ... recording of patient data for quick and correct diagnosis ...
(Date:12/11/2014)... and Markets , http://photos.prnewswire.com/prnh/20130307/600769 ... the addition of the "Biometrics Market in the ... One major trend emerging in this market is ... is important to upgrade biometric solutions to the latest ...
Breaking Biology News(10 mins):Defense Logistics Agency Launches DNA Marking Capability to Strengthen Microcircuit Supply Chain 2Defense Logistics Agency Launches DNA Marking Capability to Strengthen Microcircuit Supply Chain 3Global Chemical Sensor Market 2015-2019: Key Vendors are Abbott Laboratories, Bayer, Hoffmann La-Roche, Johnson & Johnson, NGK Spark Plugs and Robert Bosch 2Biometrics Market in the APAC Region 2015-2019: Key Vendors are 3M Cogent, NEC, Safran and Suprema 2
... for predicting biodiversity than biology",Research published in the May ... about biodiversity and opens up new avenues for predicting ... patterns. In the article, an international group ... in a river system can be accurately predicted with ...
... commerce of ornamental stones has grown all over ... decided solid support to the aesthetics of natural ... Marble is, undoubtedly, the ornamental stone par excellence. ... sculptural works which constitute the most important pieces ...
... the May 2008 Pediatric Academic Societies and Asian Society ... adolescent obesity negatively impacts vascular endothelial function, which relates ... in the U.S. during the past 20 years and ... The incidence of obesity in children is also increasing ...
Cached Biology News:Biodiversity -- it's in the water 2Development of new techniques to understand marble quality and durability 2Study supports reason for concern in childhood and adolescent obesity 2
(Date:1/22/2015)... Eckert & Ziegler Vitalea Science (EZVS), ... to the pharmaceutical and biotech industry, has announced that ... the position of Director of Science & Technology. , ... experience in drug metabolism and bioanalysis to EZVS in ...
(Date:1/22/2015)... Jan. 22, 2015  Transwestern | RBJ today announces the firm ... space for Shire a leading biopharmaceutical company, at Two Ledgemont ... RBJ,s Robert Richards , president, and Brian Cohen ... the entire five-floor building at 95 Hayden Ave. ...
(Date:1/22/2015)... (PRWEB) January 22, 2015 Crystal Diagnostics (CDx) ... that it has received AOAC-PTM Certifications for the six non-O157 ... and O145; collectively referred to as STEC or the “Big-6”) ... colony forming unit (cfu) per 325 g of raw ground ...
(Date:1/22/2015)... (PRWEB) January 22, 2015 Controlled Substance ... Alliance, which helps companies check the legal requirements around ... expand to China. , As their international operations ... globally adopting software solutions built as a result of ...
Breaking Biology Technology:Eckert & Ziegler Vitalea Science appoints Mark Seymour, PhD as Director of Science & Technology 2Eckert & Ziegler Vitalea Science appoints Mark Seymour, PhD as Director of Science & Technology 3Transwestern?RBJ Advises Shire in 202,000 SF Lease, Creating Boston's Largest Suburban Biotech Campus 2Crystal Diagnostics Awarded AOAC-PTM Accreditation for the Rapid Detection of “Big 6” E.coli Food Pathogens 2Global Compliance Service for Controlled Substances to Expand to China 2
... - Combined Company Will Have Three Oncology Products in Clinic -, - Lead Candidate ... ... Wednesday, May 28th, at 11:00 a.m. Pacific ... Time -, BOTHELL, WA and ...
... A new study into the potential health hazards ... predicts that the molecules are easily absorbed into ... the molecules could be toxic to humans and ... Calgary biochemist Peter Tieleman, post-doctoral fellow Luca Monticelli ...
... Income Up 132% Year-Over-Year, SHANGHAI, China, May ... WX ), a leading pharmaceutical, biotechnology and medical ... China and,the United States, today announced its selected ... 31, 2008., (Logo: ...
Cached Biology Technology:Sonus Pharmaceuticals and OncoGenex Technologies to Merge 2Sonus Pharmaceuticals and OncoGenex Technologies to Merge 3Sonus Pharmaceuticals and OncoGenex Technologies to Merge 4Sonus Pharmaceuticals and OncoGenex Technologies to Merge 5Sonus Pharmaceuticals and OncoGenex Technologies to Merge 6Sonus Pharmaceuticals and OncoGenex Technologies to Merge 7Sonus Pharmaceuticals and OncoGenex Technologies to Merge 8How buckyballs hurt cells 2WuXi PharmaTech Announces First Quarter 2008 Results 2WuXi PharmaTech Announces First Quarter 2008 Results 3WuXi PharmaTech Announces First Quarter 2008 Results 4WuXi PharmaTech Announces First Quarter 2008 Results 5WuXi PharmaTech Announces First Quarter 2008 Results 6WuXi PharmaTech Announces First Quarter 2008 Results 7WuXi PharmaTech Announces First Quarter 2008 Results 8WuXi PharmaTech Announces First Quarter 2008 Results 9WuXi PharmaTech Announces First Quarter 2008 Results 10WuXi PharmaTech Announces First Quarter 2008 Results 11
From micro to giga sizes, from single prep to high-throughput, Invitrogen's range of plasmid purification kits offers superior performance to match the demands of your downstream application....
Request Info...
... GeneBLAzer cell-based assays utilize the ... of the negatively charged fluorescent beta-lactamase ... esters readily enter the cell, where ... converts them into their negatively charged ...
Chlorine-36, 3.7 MBq, 100 uCi. 0.1-0.3 HCl.< 111 MBq/g Cl, < 3 mCi/g Cl.Dispensed to order. Please inquire for alternative pack sizes. Category: Radiochemicals &Radiation Safety, Radiochemicals....
Biology Products: