Navigation Links
Reducing gene-damaging impurities in medicines
Date:9/29/2010

Drug manufacturers have been adjusting to strict new government standards that limit the amount of potentially harmful impurities in medicine, according to the cover story of the current issue of Chemical & Engineering News (C&EN), ACS' weekly newsmagazine. The impurities are "genotoxic," capable of damaging the DNA in genes.

C&EN Senior Correspondent Ann Thayer notes that internationally accepted regulations long have limited the levels of impurities permitted in prescription drugs. But guidelines have not covered so-called genotoxic impurities (GTIs), substances that can potentially increase the risk of cancer. That changed in 2007, after European regulators put guidelines in place and the U.S. Food and Drug Administration soon after followed suit. The challenging new limits for GTIs are about 1,000 times lower than the levels allowed for most other impurities.

Although drug companies are complying with the guidelines, some regard the limits as too strict, the article notes. Some industry scientists also question the approaches proposed to categorize and test for GTIs. Nevertheless, drug companies are working to change or control their manufacturing methods so that GTIs either do not form in the first place or form at much lower levels.


'/>"/>

Contact: Michael Bernstein
m_bernstein@acs.org
202-872-6042
American Chemical Society
Source:Eurekalert

Page: 1

Related biology news :

1. Forest peoples rights key to reducing emissions from deforestation
2. Providing toilets, safe water is top route to reducing world poverty: UN University
3. Pollinator decline not reducing crop yields just yet
4. Reducing the damage of a heart attack
5. Effectiveness of progesterone in reducing preterm births may be altered by genetic predisposition
6. Biofuels can provide viable, sustainable solution to reducing petroleum dependence
7. Reducing CO2 through technology and smart growth
8. Reducing animal experiments through top-class research
9. Reducing the roadworks
10. The coming of biofuels: Study shows reducing gasoline emissions will benefit human health
11. Reducing risk of hospitalization in the elderly
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/24/2017)... , Jan. 24, 2017 Biopharm Reports ... the laboratory use of nuclear magnetic resonance spectroscopy ... end-users and profiled current practices, developments, trends and ... well as growth and opportunities. These areas include ... NMR instruments, needs and innovation requirements, hyphenated NMR ...
(Date:1/23/2017)...  The latest mobile market research from Acuity Market ... The quarterly average price of a biometric smartphone decreased ... 2016.  There are now 120 sub-$150 models on the ... just 28 a year ago at an average price ... Most , Acuity Market Intelligence Principal, "Biometric Smartphones are ...
(Date:1/19/2017)... , January 19, 2017 According to a new report ... Forecast, 2014 - 2022," the global biometric sensor market is expected to garner ... 2022. In 2015, Asia-Pacific dominated the global market and ... sectors. Continue Reading ... ...
Breaking Biology News(10 mins):
(Date:2/23/2017)... 23, 2017 /PRNewswire/ - The Fight Against Cancer Innovation ... (OICR) are pleased to report that Fusion Pharmaceuticals Inc. ... Johnson & Johnson Innovation – JJDC, Inc. (JJDC) as ... HealthCap, TPG Biotechnology Partners, and Genesys Capital, as well ... ...
(Date:2/23/2017)... ... February 23, 2017 , ... ... clearance to begin marketing the SPEAC® System, the Brain Sentinel® Seizure Monitoring and ... or in healthcare facilities during periods of rest. A lightweight, non-invasive monitor is ...
(Date:2/23/2017)... , Feb. 23, 2017  Capricor Therapeutics, Inc. (NASDAQ: CAPR), ... medical conditions, today announced that Linda Marbán, Ph.D, president and ... investor conferences: Cowen and Company 37th ... am ET Boston, MA ... 9:00 am PT (12:00 pm ET) Dana Point, ...
(Date:2/22/2017)... ... February 22, 2017 , ... Kernel ... Kendall Research Systems, LLC (KRS) clinical development program. KRS is a neurotechnology ... for research and clinical applications. The terms of the transaction were not disclosed. ...
Breaking Biology Technology: