Navigation Links
Reducing gene-damaging impurities in medicines
Date:9/29/2010

Drug manufacturers have been adjusting to strict new government standards that limit the amount of potentially harmful impurities in medicine, according to the cover story of the current issue of Chemical & Engineering News (C&EN), ACS' weekly newsmagazine. The impurities are "genotoxic," capable of damaging the DNA in genes.

C&EN Senior Correspondent Ann Thayer notes that internationally accepted regulations long have limited the levels of impurities permitted in prescription drugs. But guidelines have not covered so-called genotoxic impurities (GTIs), substances that can potentially increase the risk of cancer. That changed in 2007, after European regulators put guidelines in place and the U.S. Food and Drug Administration soon after followed suit. The challenging new limits for GTIs are about 1,000 times lower than the levels allowed for most other impurities.

Although drug companies are complying with the guidelines, some regard the limits as too strict, the article notes. Some industry scientists also question the approaches proposed to categorize and test for GTIs. Nevertheless, drug companies are working to change or control their manufacturing methods so that GTIs either do not form in the first place or form at much lower levels.


'/>"/>

Contact: Michael Bernstein
m_bernstein@acs.org
202-872-6042
American Chemical Society
Source:Eurekalert

Page: 1

Related biology news :

1. Forest peoples rights key to reducing emissions from deforestation
2. Providing toilets, safe water is top route to reducing world poverty: UN University
3. Pollinator decline not reducing crop yields just yet
4. Reducing the damage of a heart attack
5. Effectiveness of progesterone in reducing preterm births may be altered by genetic predisposition
6. Biofuels can provide viable, sustainable solution to reducing petroleum dependence
7. Reducing CO2 through technology and smart growth
8. Reducing animal experiments through top-class research
9. Reducing the roadworks
10. The coming of biofuels: Study shows reducing gasoline emissions will benefit human health
11. Reducing risk of hospitalization in the elderly
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/7/2016)... TORONTO , June 7, 2016  Syngrafii ... begun a business relationship that includes integrating Syngrafii,s ... pilot branch project. This collaboration will result in ... for the credit union, while maintaining existing document ... http://photos.prnewswire.com/prnh/20160606/375871LOGO ...
(Date:6/1/2016)... Favorable Government Initiatives Coupled With ... Identification to Boost Global Biometrics System Market Through 2021  ... report, " Global Biometrics Market By Type, By ... 2011 - 2021", the global biometrics market is projected ... of growing security concerns across various end use sectors ...
(Date:5/9/2016)... May 9, 2016 Elevay is ... to expanding freedom for high net worth professionals seeking ... today,s globally connected world, there is still no substitute ... ever duplicate sealing your deal with a firm handshake. ... by taking advantage of citizenship via investment programs like ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... ... June 27, 2016 , ... Rolf K. Hoffmann, former senior ... the University of North Carolina Kenan-Flagler Business School effective June 27. ... Kenan-Flagler, with a focus on the school’s international efforts, leading classes and participating ...
(Date:6/24/2016)... , June 24, 2016 Epic Sciences ... detects cancers susceptible to PARP inhibitors by targeting ... cells (CTCs). The new test has already been ... in multiple cancer types. Over 230 ... damage response pathways, including PARP, ATM, ATR, DNA-PK ...
(Date:6/23/2016)... WI (PRWEB) , ... June 23, 2016 , ... ... supplements, is pleased to announce the launch of their brand, UP4™ Probiotics, into ... for over 35 years, is proud to add Target to its list of ...
(Date:6/23/2016)... Houston Methodist Willowbrook Hospital has signed ... to serve as their official health care provider. ... will provide sponsorship support, athletic training services, and ... volunteers, athletes and families. "We are ... and to bring Houston Methodist quality services and ...
Breaking Biology Technology: