Navigation Links
Reducing diet early in pregnancy stunts fetal brain development
Date:1/17/2011

SAN ANTONIO, Texas, U.S.A. (Jan. 17, 2011) Eating less during early pregnancy impaired fetal brain development in a nonhuman primate model, researchers from The University of Texas Health Science Center San Antonio reported today.

The researchers found decreased formation of cell-to-cell connections, cell division and amounts of growth factors in the fetuses of mothers fed a reduced diet during the first half of pregnancy. "This is a critical time window when many of the neurons as well as the supporting cells in the brain are born," said Peter Nathanielsz, M.D., Ph.D., director of the Center for Pregnancy and Newborn Research in the Health Science Center School of Medicine.

The study included collaborators at the Southwest Foundation for Biomedical Research (SFBR) in San Antonio and Friedrich Schiller University in Jena, Germany. The team compared two groups of baboon mothers located at SFBR's Southwest National Primate Research Center. One group ate as much as they wanted during the first half of pregnancy while the other group was fed 30 percent less, a level of nutrition similar to what many prospective mothers in the U.S. experience.

Hundreds of genes involved

"Our collaboration allowed us to determine that the nutritional environment impacts the fetal brain at both the cellular and molecular levels," said SFBR's Laura Cox, Ph.D. "That is, we found dysregulation of hundreds of genes, many of which are known to be key regulators in cell growth and development, indicating that nutrition plays a major role during fetal development by regulating the basic cellular machinery."

Moderate versus severe reduction

It is known that marked nutrient restriction, such as in famine conditions, adversely affects development of the fetal brain. Senior author Thomas McDonald, Ph.D., also of the Health Science Center, said the study "is the first demonstration of major effects caused by the levels of food
'/>"/>

Contact: Will Sansom
sansom@uthscsa.edu
210-567-2579
University of Texas Health Science Center at San Antonio
Source:Eurekalert

Page: 1 2

Related biology news :

1. Reducing emissions from shipping: Commissions Joint Research Centre sets out some options
2. Estrogen alone is effective for reducing breast cancer risk
3. UV light nearly doubles vacuums effectiveness in reducing carpet microbes
4. $1.5M grant funds research aimed at reducing strokes in children with sickle cell disease
5. Reducing gene-damaging impurities in medicines
6. Mother Nature to provide an environmentally friendly method for reducing mosquitoes
7. Reducing fossil energy use on the farm
8. Natural S-Equol suggested as critical component in SE5-OH for reducing menopausal hot flushes
9. Pennsylvania makes inroads into reducing child obesity
10. Hydrocooling shows promise for reducing strawberry weight loss, bruising
11. Researchers look at reducing yield loss for crops under stress
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/18/2014)... are too stressed they are often grouchy, grumpy, nasty, ... (BMI) at EPFL have just highlighted a fundamental synaptic ... the loss of social skills and cognitive impairment. When ... molecule in the brain. This was revealed by a ... Carmen Sandi,s team went to look for answers in ...
(Date:9/18/2014)... the protective tentacles of host anemones, but new research ... kilometres across the open ocean. Although the process of ... is the first time that the high level exchange ... Dr Steve Simpson, Senior Lecturer in Marine Biology and ... from the Australian Research Council Centre of Excellence for ...
(Date:9/17/2014)... doctoral student have designed a device based on a ... and dew., The device could provide water in drought-stricken ... Cheng Luo, professor in the Mechanical & Aerospace Engineering ... College of Engineering department, published "Bioinspired Plate-Based Fog Collectors" ... Society) Applied Materials & Interfaces ...
Breaking Biology News(10 mins):How stress tears us apart 2Expedition finds Nemo can travel great distances to connect populations 2Expedition finds Nemo can travel great distances to connect populations 3Shorebird's beak inspires UT Arlington research on water collection 2
... Fla., May 23, 2012  One size does not fit all ... U.S. consumer. According to a recent HealthFocus® International study on ... weight they need to lose, but also in their motivations ... losing weight.    "New approaches to combatting obesity ...
... N.C. -- A Duke University-led study of North Carolina ... may be higher in nonwhite toddlers than in white ... exposure to the chemicals is higher among toddlers whose ... measure of lower socioeconomic background. Hand-to-mouth activity ...
... multiple segments was an exclusive feature of land-dwelling animals. But ... eel suggests that this complex anatomy arose separately from ... land. Tarrasius problematicus was an eel-like fish ... now Scotland, in the Carboniferous period between 359 million and ...
Cached Biology News:New HealthFocus® International Study Reveals Five Very Different Weight Management Consumers 2Socioeconomics may affect toddlers' exposure to flame retardants 2Socioeconomics may affect toddlers' exposure to flame retardants 3Human-like spine morphology found in aquatic eel fossil 2Human-like spine morphology found in aquatic eel fossil 3
(Date:9/19/2014)... Sept. 19, 2014  An entire month is dedicated ... neuropathies – Charcot-Marie-Tooth disease (CMT) – a debilitating neuromuscular ... extreme muscle atrophy, weakness, and foot and hand deformities. ... millions worldwide. CMT is a progressive disease, and over ... requiring mobility devices such as leg braces, wheelchairs and ...
(Date:9/19/2014)... Sept. 19, 2014 Pfenex Inc. (NYSE MKT: ... of high-value and difficult to manufacture proteins including biosimilar ... the 21 st Annual NewsMakers in the Biotech ... Bertrand Liang , chief executive officer of Pfenex, ... and business strategy on Friday, September 26, 2014 at ...
(Date:9/19/2014)... September 19, 2014 Cereal grain ... industries will gather October 5–8, 2014, for the ... Island Convention Center in Providence, Rhode Island. The ... work of food scientists, chemists, microbiologists, nutritionists, and ... food production management. To date, 1,000 attendees have ...
(Date:9/19/2014)... -- The new , Healthcare and Life Sciences ... on PharmaBoardroom.com for free download , looks ... Spanish economy in 2009, and the austerity measures that followed, ... in times of trouble. "Despite the crisis, ... market, and the general conditions to invest are favorable to ...
Breaking Biology Technology:September is Charcot-Marie-Tooth (CMT) Awareness Month - Scheduled events, activities and important partnerships announced throughout the month! 2Pfenex to Present at Upcoming Industry Conference on September 26 2Latest Research on Cereal Grain Quality, Health Benefits and Food Production to be Presented During the AACC International Annual Meeting 2Latest Research on Cereal Grain Quality, Health Benefits and Food Production to be Presented During the AACC International Annual Meeting 3PharmaBoardroom Releases New Spain Pharmaceuticals Report 2PharmaBoardroom Releases New Spain Pharmaceuticals Report 3
... Delivers Precision Illumination Advances , ... Ann Arbor, MI (PRWEB) December 10, ... for added precision, flexibility and comfort in engineering, assembly, laboratory and inspection ... Inc. of Ann Arbor, Mich., uses a ring of 60 lights ...
... could be sustained for many years to come thanks ... Laboratory (NPL) that is applying advanced techniques to magnetic ... transistors on an integrated circuit doubles every two years. ... experts believed that when the characteristic transistor size reduces ...
... Inc. (Nasdaq: EVVV ),a global endovascular ... clearance from the U.S. Food & Drug Administration ... peripheral angioplasty balloon,catheters. ev3 expects to begin ... catheters globally in January 2009. , ...
Cached Biology Technology:60 LED Lights Enhance Magnifying Lamp for Assembly, Engineering, Inspection or Research 260 LED Lights Enhance Magnifying Lamp for Assembly, Engineering, Inspection or Research 3ev3 Inc. Receives FDA Clearance to Market EverCross and NanoCross Peripheral Angioplasty Balloons 2ev3 Inc. Receives FDA Clearance to Market EverCross and NanoCross Peripheral Angioplasty Balloons 3
...
No description available in Ensembl. Antigen: Recombinant Protein Epitope Signature Tag (PrEST)....
5(S)-HETE-d8 is used as an internal standard for the quantification of 5(S)-HETE by stable isotope dilution mass spectrometry....
Full-length cDNA clone CS0DJ013YG01 of T cells (Jurkat cell line) of Homo sapiens (human). [Source:Uniprot/SPTREMBL;Acc:Q86SZ3] Antigen: Recombinant Protein Epitope Signature Tag (PrEST)....
Biology Products: