Navigation Links
Reduced glycerin formulation of tenofovir vaginal gel safe for rectal use
Date:5/16/2012

PITTSBURGH, May 17, 2012 A change in the formulation of tenofovir gel, an anti-HIV gel developed for vaginal use, may make it safer to use in the rectum, suggests a study published online this week in the Journal of Antimicrobial Chemotherapy. In laboratory tests of rectal tissue, researchers from the Microbicide Trials Network (MTN) found that the reformulated gel was less harmful to the lining of the rectum than the original vaginal formulation, and just as effective in protecting cells against HIV.

"The lining of the rectum is much more fragile than the vaginal epithelium, so we can't be certain a product like tenofovir gel that is safe for vaginal use will be completely safe to use in the rectum," said lead study author Charlene Dezzutti, Ph.D., associate professor of obstetrics, gynecology and reproductive sciences at the University of Pittsburgh School of Medicine and principal investigator of the MTN Network Laboratory. "We are very encouraged by our laboratory data that suggest the reformulated gel could be safer for rectal use, and serve as a dual compartment gel for use in both the vagina and rectum."

Tenofovir gel has shown some promise in reducing HIV risk in women through vaginal sex. But because the rectal epithelium the lining of the rectum that serves as the first line of defense against HIV is much thinner than the vaginal lining, the gel may not be safe or effective to use rectally. Indeed, unprotected anal sex is 10 to 20 times more likely to result in HIV infection than unprotected vaginal intercourse. By its nature, tenofovir gel is hyperosmolar contains a higher concentration of sugars and salts relative to cells. This quality could have a harmful effect on the rectal lining by causing epithelial cells to shrink as they purge water to achieve balance. Weakened in this manner, the rectal epithelium may be less able to protect against HIV.

To make tenofovir gel safe and more amenable to rectal use,
'/>"/>

Contact: Clare Collins
collcx@upmc.edu
412-641-7299
Microbicide Trials Network
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. How the ecological risks of extended bioenergy production can be reduced
2. Study: Quebec ban on fast-food ads reduced consumption of junk food
3. New fermented soy ingredient containing S-equol significantly reduced hot flash frequency
4. Reduced bone density, stunted growth in turtles exposed to common chemical
5. Gene regulatory protein is reduced in bipolar disorder
6. Aquarium fishes are more aggressive in reduced environments, a new study finds
7. Vitamin D deficiency associated with reduced lung function
8. Identifying factors in atrazines reduced weed control
9. Combination therapy reduced HER2-positive breast cancers
10. More than 1,000 tigers reduced to skin and bones in last decade
11. Chefs can create reduced-calorie restaurant foods
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/31/2015)... The 10 th International Conference on Genomics ... 22-25, 2015, in Shenzhen , ... 10 th anniversary this year. Since its inauguration in ... annual meetings in the ,omics, fields, and is one of ... ICG-10 focuses on recent breakthroughs and advances in ,omics, ...
(Date:7/27/2015)... SAN JOSE, Calif. , July 27, 2015 ... leading developer of human interface solutions, today announced ... ClearPad ® touchscreen solution for its stylish ... controller for its proven reliability, low power and ... with a wet finger. Huawei designers also required ...
(Date:7/23/2015)... July 23, 2015 Aware, Inc. (NASDAQ: AWRE ... reported financial results for its second quarter ended June 30, ... 2015 was $4.5 million, a decrease of 33% compared to ... in the second quarter of 2015 was $0.3 million, or ... $0.04 per diluted share, in the same period a year ...
Breaking Biology News(10 mins):The 10th International Conference on Genomics (ICG-10) to Open in October 2Synaptics Touchscreen Solution Powers New Huawei Watch 2Synaptics Touchscreen Solution Powers New Huawei Watch 3Aware, Inc. Reports Second Quarter 2015 Financial Results 2Aware, Inc. Reports Second Quarter 2015 Financial Results 3Aware, Inc. Reports Second Quarter 2015 Financial Results 4Aware, Inc. Reports Second Quarter 2015 Financial Results 5Aware, Inc. Reports Second Quarter 2015 Financial Results 6
... -- From a bike path in Montana to a ... fanned out last June to capture high-resolution images for ... even broader participation in their efforts to document global ... for the solstice week of Dec. 19-26., The ...
... from the University of Sheffield comparing rats and mice ... whiskers were an important milestone in the evolution of ... and automatic tracking, the research team, which was led ... Psychology, have shed light on how rodents such as ...
... EAST LANSING, Mich. -- A diet high in fiber ... is tied to a lower risk of heart disease ... Michigan State University. A study led by Joseph Carlson ... reduce metabolic syndrome a collection of risk factors including ...
Cached Biology News:GigaBlitz event seeks citizen scientists to capture images of nearby biodiversity 2GigaBlitz event seeks citizen scientists to capture images of nearby biodiversity 3Whiskers marked milestone in evolution of mammals from reptiles 2More fiber, but not necessarily less fat, good for teen diets 2
(Date:8/3/2015)... ... , ... Nine field days to promote practices that improve soil health will ... Health Partnership , the field days will demonstrate how changing certain practices, such as ... income. , Brent Bible has practiced no-till farming and planted cover crops on his ...
(Date:8/3/2015)... /PRNewswire/ - RepliCel Life Sciences Inc. (TSX.V: RP) (OTCQB: REPCF), ... of autologous cell therapies, announced today that RepliCel,s CEO, ... held in Minneapolis, Minnesota on August ... will highlight RepliCel,s 18-month milestones including CE Mark for its ... , clinical data from both RCT-01 (tendon) and RCS-01 (skin) ...
(Date:7/31/2015)... ... July 31, 2015 , ... ... detection and quantification of partially hydrolyzed gluten in foods, has been accepted by ... the method “Partially Hydrolyzed Gluten in Fermented Cereal-Based Products by R5 Competitive ELISA,” ...
(Date:7/30/2015)... ... July 30, 2015 , ... The 2015 Market Research Report on the ... of the global Propanol market with a focus on the Chinese situation. Major companies ... Chemicals, Oxea, ISU Chemical, Sanofi, Royal Dutch Shell, LG Chem and Zhejiang Xinhua Chemical. ...
Breaking Biology Technology:Soil Health Field Days Kick Off Throughout Midwest 2Soil Health Field Days Kick Off Throughout Midwest 3RepliCel Presenting at InvestMNT Investor Conference in Minneapolis 2RIDASCREEN® Competitve Gliadin Receives AOAC Official First Action Status 2Global Propanol Market Technical Data and Manufacturing Analysis 2020 2Global Propanol Market Technical Data and Manufacturing Analysis 2020 3
... Easily Locating Adhererent , Cells , , ... , , ... cells that have been used for microinjection. These sterile coverslips , ... with the original microgrid patterns it is easy ...
... , , , , , ... Kiel, Germany , Susanne Wagner, Eppendorf AG, , ... Introduction , , , , , ... Ongoing developments of tubes, pipettes, and pipette tips enable drastic ...
... reporting system for ... Mary Buchanan Chao-Feng Zheng ,Stratagene , Stratagenes ... is designed for studying the activation,of the nuclear factor ... play an essential role in inducible gene expression,during immune ...
Cached Biology Technology:A membrane-lid tube for bacteria cultivation and freeze-drying 2A membrane-lid tube for bacteria cultivation and freeze-drying 3A membrane-lid tube for bacteria cultivation and freeze-drying 4A membrane-lid tube for bacteria cultivation and freeze-drying 5A membrane-lid tube for bacteria cultivation and freeze-drying 6A membrane-lid tube for bacteria cultivation and freeze-drying 7Cis-Reporting System Monitors Intracellular Calcium Mobilization 2Cis-Reporting System Monitors Intracellular Calcium Mobilization 3Cis-Reporting System Monitors Intracellular Calcium Mobilization 4Cis-Reporting System Monitors Intracellular Calcium Mobilization 5
Prepared from plasminogen by activation with immobilized human uPA...
Human FADD Affinity Purified Polyclonal Ab...
(3-[125I]iodotyrosyl26)Galanin (porcine), 925 kBq, 25 uCi. Category: IODINE LIGANDS....
... The high-performance triple quadrupole 1200L sets ... today's cost-conscious environment - incorporating the ... for all liquid chromatography analytical needs. ... interface and the Transmission Quadrupole Analyzer ...
Biology Products: