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Rediscovery: MBL scientists confirm role for mysterious cell component, the nucleolinus
Date:7/22/2010

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This function of the nucleolinus, which is closely associated with a structure called the nucleolus, could clarify recent studies indicating an important role for the nucleolus in cell division. "When people talk about the nucleolus playing a direct role in cell cycle regulation, it may very well be that it's the nucleolinus," Mark Alliegro says.

Mark Alliegro and his colleagues speculate that the nucleolinus may be responsible for recruiting proteins required by centrosomes, which have long been known to play an important role in cell division. "What we're doing now is attempting to answer some functional questions about the nucleolinus in Spisula cells," he says. "But we're also moving it into other systems that are easier to experiment in." They are planning to study the role of the nucleolinus in mammalian cells.

The MBL has other close connections with the long but sparse history of nucleolinus research. Former MBL visiting investigators Thomas H. Montgomery Jr. of the University of Texas (in the 1890s) and Robert D. Allen of Dartmouth College (in the 1950s) both studied the structure before it faded back into obscurity. "Of the people that have studied the nucleolinus," Mark Alliegro says, "more have been at the MBL than any place else."


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Contact: Diana Kenney
dkenney@mbl.edu
508-289-7139
Marine Biological Laboratory
Source:Eurekalert  

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Rediscovery: MBL scientists confirm role for mysterious cell component, the nucleolinus
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