Navigation Links
Rediscovery: MBL scientists confirm role for mysterious cell component, the nucleolinus
Date:7/22/2010

MBL, WOODS HOLE, MAWhen searching for long-lost treasure, sometimes all you need is a good flashlight.

Such a "flashlight," developed at the Marine Biological Laboratory's (MBL) Josephine Bay Paul Center, has been used to illuminate a long-neglected cellular component the nucleolinus and confirm its role in cell division. MBL scientists Mark Alliegro and Mary Anne Alliegro, and MBL visiting investigator Jonathan Henry of University of Illinois, Urbana, present their discoveries regarding the nucleolinus this week in a paper in Proceedings of the National Academy of Sciences.

The nucleolinus is a structure observed in the nucleus of many cells, including invertebrate egg cells and some mammalian cells. While it was discovered more than 150 years ago, and other scientists have proposed that is involved in cell division, difficulties in visualizing the nucleolinus inside most cells have kept that hypothesis dormant.

"Our paper reintroduces (a cell component) that was discovered and forgotten long ago," Mark Alliegro says. "When we saw a couple of interesting things about the nucleolinus, I asked, 'What does it do?' I went to the library and quickly found out that nobody knew."

He and his colleagues went on to develop a probe that binds to specific nucleolinar molecules in egg cells of the surf clam Spisula solidissima. Using the label to keep an eye on the nucleolinus, they found that it was associated with structures required for cell division. Follow-up experiments in which the nucleolinus was targeted by a laser resulted in failed cell division and disruption of structures necessary for the process.

"We've known for a long time that there are elements in the cytoplasm that need to be assembled for the cell to divide," Mark Alliegro says. "But this tells us that elements in the cytoplasm and in the nucleus have to join together to make the apparatus that separates chromosomes [an important part of cell division]."

This function of the nucleolinus, which is closely associated with a structure called the nucleolus, could clarify recent studies indicating an important role for the nucleolus in cell division. "When people talk about the nucleolus playing a direct role in cell cycle regulation, it may very well be that it's the nucleolinus," Mark Alliegro says.

Mark Alliegro and his colleagues speculate that the nucleolinus may be responsible for recruiting proteins required by centrosomes, which have long been known to play an important role in cell division. "What we're doing now is attempting to answer some functional questions about the nucleolinus in Spisula cells," he says. "But we're also moving it into other systems that are easier to experiment in." They are planning to study the role of the nucleolinus in mammalian cells.

The MBL has other close connections with the long but sparse history of nucleolinus research. Former MBL visiting investigators Thomas H. Montgomery Jr. of the University of Texas (in the 1890s) and Robert D. Allen of Dartmouth College (in the 1950s) both studied the structure before it faded back into obscurity. "Of the people that have studied the nucleolinus," Mark Alliegro says, "more have been at the MBL than any place else."


'/>"/>

Contact: Diana Kenney
dkenney@mbl.edu
508-289-7139
Marine Biological Laboratory
Source:Eurekalert  

Related biology news :

1. Jefferson scientists deliver toxic genes to effectively kill pancreatic cancer cells
2. Scientists identify novel inhibitor of human microRNA
3. Argonne scientists peer into heart of compound that may detect chemical, biological weapons
4. MU scientists go green with gold, distribute environmentally friendly nanoparticles
5. Scientists identify gene that may contribute to improved rice yield
6. Scientists discover why a mothers high-fat diet contributes to obesity in her children
7. MU scientists see how HIV matures into an infection
8. Earth scientists keep an eye on Texas
9. Thinking it through: Scientists call for policy to guide biofuels industry toward sustainability
10. Scientists identify a molecule that coordinates the movement of cells
11. Scientists Find new migratory patterns for Mediterranean and Western Atlantic bluefin tuna
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Rediscovery: MBL scientists confirm role for mysterious cell component, the nucleolinus
(Date:6/2/2016)... , June 2, 2016 The Department ... has awarded the 44 million US Dollar project, for the ... Vehicle Plates including Personalization, Enrolment, and IT Infrastructure , ... in the production and implementation of Identity Management Solutions. Numerous ... however Decatur was selected for the ...
(Date:6/1/2016)... -- Favorable Government Initiatives Coupled With Implementation ... to Boost Global Biometrics System Market Through 2021  ... " Global Biometrics Market By Type, By End ... - 2021", the global biometrics market is projected to ... growing security concerns across various end use sectors such ...
(Date:5/16/2016)... --  EyeLock LLC , a market leader of iris-based ... IoT Center of Excellence in Austin, Texas ... embedded iris biometric applications. EyeLock,s iris authentication ... with unmatched biometric accuracy, making it the most proven ... platform uses video technology to deliver a fast and ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... (PRWEB) , ... June 23, 2016 , ... ... is pleased to announce the launch of their brand, UP4™ Probiotics, into Target ... over 35 years, is proud to add Target to its list of well-respected ...
(Date:6/23/2016)... TORONTO , June 23, 2016 /PRNewswire/ - ... Ontario biotechnology company, Propellon ... the development and commercialization of a portfolio of ... cancers. Epigenetic targets such as WDR5 represent an ... contribute significantly in precision medicine for cancer patients. ...
(Date:6/23/2016)... HOUSTON , June 23, 2016 ... agreement with the Cy-Fair Sports Association to serve ... of the agreement, Houston Methodist Willowbrook will provide ... education and connectivity with association coaches, volunteers, athletes ... partner with the Cy-Fair Sports Association and to ...
(Date:6/23/2016)... Cancer Foundation (PCF) is pleased to announce 24 new Young Investigator (YI) ... of the Class of 2016 were selected from a pool of 128 applicants ... the Class of 2016 PCF Young Investigators ... ... ...
Breaking Biology Technology: