Navigation Links
Redefining what it means to be a prion
Date:4/2/2009

CAMBRIDGE, Mass. (April 2, 2009) Whitehead Institute researchers have quintupled the number of identifiable prion proteins in yeast and have further clarified the role prions play in the inheritance of both beneficial and detrimental traits.

"The big debate in the field is are the prions functional are they evolved to be prions, or are they always a disease, as in "mad cow'" disease in mammals," says Randal Halfmann, a research assistant in Whitehead Member Susan Lindquist's lab, and coauthor of the paper featured on the cover of the April 3 issue of the journal Cell. "We wanted to find more prions and see what they're doing, so we could answer that question."

The Lindquist lab's work further alters the way researchers view prions, from biological anomalies to mediators of trait inheritance and adaptations to fluctuating environments. work shifts the way researchers view prions, from being a biological anomaly to a key

Prions' bad reputation was fixed in the public's mind by "mad cow" disease. In the late 1980s, an unidentified disease infected more than 100,000 British cows and spread to humans, eventually killing more than 200 people. The disease causes progressive degeneration of physical and mental abilities, which ultimately lead to death.

Scientists found the infectious agent was a prion, a misfolded version of the PrP protein found clumped together in brain cells. Brain matter in PrP-infected animals takes on a spongy appearance, lending the condition its formal name, bovine spongiform encephalitis (BSE).

Unlike other proteins, the misfolded PrP protein is transmissible. When the misfolded PrP protein is introduced to healthy cells, it can convert normally-folded PrP proteins to its misfolded shape and cause a clumping cascade characteristic of prions.

Over the years, researchers have identified a small number of other prions in humans and other animals, most of which cause degenerative
'/>"/>

Contact: Nicole Giese
giese@wi.mit.edu
617-258-6851
Whitehead Institute for Biomedical Research
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Less Arctic ice means higher risks, experts warn
2. Bad news for coastal ocean: less fish out, means more nitrogen in
3. Scientists demonstrate means of reducing Alzheimers-like plaques in fly brain
4. Researchers devise means to create blood by identifying earliest stem cells
5. Shorter wait means longer life for kidney transplant candidates
6. Self-digestion as a means of survival
7. Prions and retroviruses -- an unholy alliance?
8. NIH awards researcher $1.5 million new innovator grant for fruit-fly studies of prion proteins
9. Lymph nodes can be key in spreading prion infectivity
10. Scripps scientists develop new tests that identify lethal prion strains quickly and accurately
11. Prions show their good side
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/17/2014)... -- Valencell, a leader in performance biometric data sensor ... leaders such as Intel, Jabra, Atlas, and Scosche to ... These products will be showcased at CES 2015, taking ... . "Our partners choose PerformTek biometrics, ... with the clinical data to back it up," said ...
(Date:12/17/2014)... 2014  Automation is fundamentally transforming the travel ... at international borders. Over the past decade, ePassports, ... veteran travelers to self process through border control ... at an increasing number of airports, seaports, and ... According to Maxine Most , Principal at ...
(Date:12/11/2014)... 2014 Research and Markets ... ( http://www.researchandmarkets.com/research/twhjll/biometrics_market ) has announced the addition of ... 2015-2019"  report to their offering. ... advances in technology. With continuous advances in technology, ... the latest standard that meets the needs and ...
Breaking Biology News(10 mins):Valencell PerformTek Biometrics Power the Most Accurate Wearables at CES 2015 2Automated Border Control (ABC) Transforms the Global Travel Experience With More Than 2500 ABC eGates and APC Kiosks Deployed In Airports, Seaports, and Land Borders Worldwide 2Biometrics Market in the APAC Region 2015-2019: Key Vendors are 3M Cogent, NEC, Safran and Suprema 2
... native flora is in sourcing genetically diverse seed not ... seed. "A common belief is that local native ... projects," says Dr Linda Broadhurst from CSIRO, Australia,s national ... that local seed is adapted to local conditions and ...
... A wild fungus has been found to produce a ... microscopic fungus, known as Gliocladium roseum (NRRL ... rainforest. Gary Strobel of Montana State University ... and that the particular diesel components produced can be ...
... discovered a metabolic deficiency in pancreatic cancer cells that ... deadliest of all cancers. Published in the October ... study results indicate that pancreatic cancer cells cannot produce ... in cell division, immune function and hormone regulation. By ...
Cached Biology News:Obscure fungus produces diesel fuel components 2UC Davis researchers discover Achilles' heel in pancreatic cancer 2UC Davis researchers discover Achilles' heel in pancreatic cancer 3
(Date:12/15/2014)... METTLER TOLEDO is pleased to announce that the ... PVM technology , is now available. The new ... continuously captures high-resolution images under a wide range ... a report pairing the most relevant images to ... compelling blend of high resolution images and trend ...
(Date:12/15/2014)... -- Origin Agritech Limited (NASDAQ GS: SEED) (" Origin ", or ... in China , today announced that the ... September 30, 2014, before the market opens on Thursday, January ... on January 8, 2015, at 8:00 a.m. ET / 9:00 ... results. To participate in the call, please dial +1-888-346-8982 in ...
(Date:12/13/2014)... Maryland (PRWEB) December 12, 2014 Clarassance, ... today announced its new name: Therabron Therapeutics , ... therapy and bronchioles (a type of structure in the ... the company’s mission to develop novel protein therapeutics for ... of directors decided to change the name to mark ...
(Date:12/13/2014)... 13, 2014 According to population studies: ... between now and 2030." If a population explosion like ... most populous state in the country. , To that ... the Future of North Carolina Forum on December 16th ... have the necessary infrastructure in place? Enough clean water? ...
Breaking Biology Technology:New Real-Time In Situ Probe-Based Video Microscope from METTLER TOLEDO 2Origin Agritech Limited to Announce Fiscal 2014 Annual Financial Results on January 8th, 2015 2Origin Agritech Limited to Announce Fiscal 2014 Annual Financial Results on January 8th, 2015 3Maryland-based Biotech Company's Path Forward in Treating Respiratory Diseases Sparks Name Change 2North Carolina Chamber of Commerce: Asking Questions & Gathering Answers with a Futurist 2
... , , STAMFORD, Conn. ... and Transcept Pharmaceuticals, Inc. (Nasdaq: TSPT ) today announced ... Intermezzo ((R)) (zolpidem tartrate sublingual tablet) in the United States. If ... ((R)) has the potential to be the first prescription sleep aid ...
... ... Terrosa Technologies, a provider of Cloud and SaaS ... world wide sales, marketing and distribution responsibilities with Integrated Clinical ... collaboration Clinical Trial Management System (CTMS) tool for the pharmaceutical ...
... time bomb, a deadly mechanism that can be used against ... Universiteit Brussel (VUB) were able to determine the structure and ... for finding ways to set the clock on this internal ... new class of antibiotics. The research was accepted for ...
Cached Biology Technology:Purdue Pharmaceutical Products L.P. and Transcept Pharmaceuticals, Inc. Sign Exclusive Agreement to Commercialize Intermezzo(R) in the United States 2Purdue Pharmaceutical Products L.P. and Transcept Pharmaceuticals, Inc. Sign Exclusive Agreement to Commercialize Intermezzo(R) in the United States 3Purdue Pharmaceutical Products L.P. and Transcept Pharmaceuticals, Inc. Sign Exclusive Agreement to Commercialize Intermezzo(R) in the United States 4Purdue Pharmaceutical Products L.P. and Transcept Pharmaceuticals, Inc. Sign Exclusive Agreement to Commercialize Intermezzo(R) in the United States 5Purdue Pharmaceutical Products L.P. and Transcept Pharmaceuticals, Inc. Sign Exclusive Agreement to Commercialize Intermezzo(R) in the United States 6Purdue Pharmaceutical Products L.P. and Transcept Pharmaceuticals, Inc. Sign Exclusive Agreement to Commercialize Intermezzo(R) in the United States 7Terrosa Technologies Assigned as Exclusive Reseller for Inclinicalperform CTMS/SaaS Clinical Trials Collaboration Software 2Terrosa Technologies Assigned as Exclusive Reseller for Inclinicalperform CTMS/SaaS Clinical Trials Collaboration Software 3Bacteria pack their own demise 2Bacteria pack their own demise 3
Rat polyclonal to Vitamin B3 ( Abpromise for all tested applications). Antigen: Chemical / Small Molecule, Vitamin B3 conjugated to BSA....
Request Info...
Amyloid stain....
Dopamine D2 and D3 receptor, human and possibly mouse. AB1502 detects 40 ng of dopamine receptor peptide by ELISA. AB1502 is not neutralizing....
Biology Products: