Navigation Links
Red blood cells have a tiny but effective protector -- microRNA
Date:7/31/2010

h red blood cells are destroyed in large numbers, or in disorders of abnormal blood cell production. The current study used knockout micebioengineered animals in which the miR-451 gene was removed and could not function.

They found that preventing the activity of miR-451 produced only modest effectsmild anemia in the micebut when the team subjected mice to oxidant stress by dosing them with a drug that produces free radicals, the mice had profound anemia. The oxygen radicals attacked hemoglobin, the iron-carrying molecule in red blood cells.

"This is a common theme in microRNAsfrequently, they don't play a central role during tissue formation or normal conditions, but they have a strong protective effect when an organism is stressed," said Weiss. "Over evolutionary time, red blood cells have evolved ways to protect themselves; one of those ways is the action of microRNA."

Weiss's team found that miR-451, acting through intermediate steps on a signaling pathway, affects a key protein, FoxO3. As a transcription factor, FoxO3 regulates hundreds of genes; in this case, FoxO3 stimulates specific genes that protect red blood cells from oxidant stress. The knockout mice in this study, having lost miR-451's function, showed impaired FoxO3 activity, and less ability to protect their red blood cells.

The regulatory pathway seen here, Weiss added, may have medical implications beyond blood cell development. "This finding does not have immediate clinical application for patients with blood diseases, but it sheds light on how microRNAs fine tune physiological functions in different contexts," said Weiss. FoxO3 regulates anti-oxidant functions in heart cells and also acts as a tumor suppressor, so miR-451 may have an important role in heart protection and in fighting cancers. "Further studies may broaden our knowledge of how this microRNA may defend the body against disease," he added.


'/>"/>

Contact: John Ascenzi
Ascenzi@email.chop.edu
267-426-6055
Children's Hospital of Philadelphia
Source:Eurekalert

Page: 1 2

Related biology news :

1. Rare and common genetic variations responsible for high triglyceride levels in blood
2. Noninvasive MR imaging of blood vessel growth in tumors using nanosized contrast agents
3. UT MD Anderson study ties abnormal cells in blood to lung cancer
4. Adaptation in mole blood aids tunnelling
5. Toward making extended blood group typing more widely available
6. Pitt researchers find new proteins that regulate blood pressure, flow
7. For lambs, a pasture a week keeps blood suckers away
8. Waters unexpected role in blood pressure control
9. Reprogrammed human blood cells show promise for disease research
10. Cheap, simple, noninvasive blood test may replace invasive diagnostic techniques in early pregnancy
11. Dark chocolate lowers blood pressure
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/19/2014)... Research and Markets ( http://www.researchandmarkets.com/research/8kmfcn/iphone_5s ... "iPhone 5S Fingerprint Sensor - Apple/AuthenTec TMDR92 & ... offering. http://photos.prnewswire.com/prnh/20130307/600769 ... July 2012, Apple introduced the fingerprint reading feature ... only device of Apple incorporating such a feature, ...
(Date:12/19/2014)... , Dec. 18, 2014 Research and Markets ... of the "Micro Market Monitor: North America Perimeter ... http://photos.prnewswire.com/prnh/20130307/600769 The ... at a CAGR of 3.6% from 2014 to 2019. ... this market, Canada is expected ...
(Date:12/19/2014)...  23andMe, Inc., the leading personal genetics company, today ... differences in genetic ancestry of individuals from across ... immigrants first arrived more than four hundred years ago, ... as a meeting place for peoples from different continents. ... mixing of peoples with African, European, and American origins ...
Breaking Biology News(10 mins):iPhone 5S Fingerprint Sensor - Apple/AuthenTec TMDR92 & Sapphire - Technology Report 2Micro Market Monitor: North America Perimeter Security Systems Market (Intrusion Detection Sensor, Video Surveillance, Communication/Alarm and Notification, Access Control System) 2Micro Market Monitor: North America Perimeter Security Systems Market (Intrusion Detection Sensor, Video Surveillance, Communication/Alarm and Notification, Access Control System) 323andMe Study Sketches Genetic Portrait of the United States 223andMe Study Sketches Genetic Portrait of the United States 323andMe Study Sketches Genetic Portrait of the United States 4
... , This release is available in ... discovered a mechanism that helps to explain resilience ... work. The new findings, in the reward circuit ... high tech dragnet for compounds that boost the ...
... Researcher in the University of Bristol,s School of Biological Sciences ... as a cue to find coral reefs, but was amazed ... larvae which must quickly find a safe place to ... can do the same thing. The team designed a ...
... For years, researchers have known that resistance exercise training ... another force can be one of the most effective ... But many older people are unable to get the full ... as arthritis that prevent them from lifting enough weight to ...
Cached Biology News:Resilience factor low in depression, protects mice from stress 2Resilience factor low in depression, protects mice from stress 3Muscle mass in elderly boosted by combining resistance exercise and blood flow restriction 2
(Date:12/19/2014)... (PRWEB) December 19, 2014 Bioject ... developer and manufacturer of needle-free injection technology, today ... with Immunomic Therapeutics, Inc. (“ITI”) for ITI to ... with its LAMP™ vaccine platform. , In ... exclusive Worldwide license to the Biojector®-2000 that triggers ...
(Date:12/19/2014)... 2014 Charm Sciences is pleased to ... Detection of Aflatoxin M1 in raw commingled milk is ... party validation. The peer reviewed report of the validation ... for Agricultural and Fisheries Research (ILVO-T&V) has been published ... B1, the most toxic aflatoxin and a known carcinogen, ...
(Date:12/19/2014)... BioPlus Specialty Pharmacy (BioPlus), one ... of Nick Maroulis, Pharm.D. to the newly created position ... In this position, Dr. Maroulis will continue to manage ... of our multi-site pharmacies as the company expands. Dr. ... that time he has served in many different capacities ...
(Date:12/19/2014)... Ill. , Dec. 19, 2014 Naurex ... develop novel drugs for diseases of the central nervous ... president and chief executive officer, will present at the ... Riedel,s presentation will take place at 3:00 p.m. PST ... Francis in San Francisco, Calif. ...
Breaking Biology Technology:Bioject and Immunomic Therapeutics Enter into an Agreement for License of Needle-Free Technology for LAMP-vax Vaccines 2Bioject and Immunomic Therapeutics Enter into an Agreement for License of Needle-Free Technology for LAMP-vax Vaccines 3Charm Sciences Achieves Independent Validation of First 15 Minute Quantitative Screening Method for Aflatoxin M1 2BioPlus Specialty Pharmacy Promotes Dr. Nick Maroulis to Vice President of Specialty Pharmacy Services 2Naurex to Present at 33rd Annual J.P. Morgan Healthcare Conference 2
... politics aside, every biologist knows that men and women truly ... area where those differences come to the fore: around 80 ... Social play behaviors also differ greatly between the sexes - ... girls. , ,Early in human development, critical brain proteins known ...
... The life sciences company Promega announced on Tuesday a ... that had been pending before the U.S. District Court ... Promega will hold a worldwide non-exclusive license from Benitec ... DNA-directed RNA interference (ddRNAi) technology. Promega will also receive ...
... an online provider of digital sheet music, announced on Tuesday ... Group to provide Word Music's collection of Christian music on ... , ,Word Music, a division of Warner Music Group based ... music from Christian songwriters such as Amy Grant, Point Of ...
Cached Biology Technology:Gender hormones may lend to social disorder therapies 2