Navigation Links
Red blood cells have a tiny but effective protector -- microRNA
Date:7/31/2010

h red blood cells are destroyed in large numbers, or in disorders of abnormal blood cell production. The current study used knockout micebioengineered animals in which the miR-451 gene was removed and could not function.

They found that preventing the activity of miR-451 produced only modest effectsmild anemia in the micebut when the team subjected mice to oxidant stress by dosing them with a drug that produces free radicals, the mice had profound anemia. The oxygen radicals attacked hemoglobin, the iron-carrying molecule in red blood cells.

"This is a common theme in microRNAsfrequently, they don't play a central role during tissue formation or normal conditions, but they have a strong protective effect when an organism is stressed," said Weiss. "Over evolutionary time, red blood cells have evolved ways to protect themselves; one of those ways is the action of microRNA."

Weiss's team found that miR-451, acting through intermediate steps on a signaling pathway, affects a key protein, FoxO3. As a transcription factor, FoxO3 regulates hundreds of genes; in this case, FoxO3 stimulates specific genes that protect red blood cells from oxidant stress. The knockout mice in this study, having lost miR-451's function, showed impaired FoxO3 activity, and less ability to protect their red blood cells.

The regulatory pathway seen here, Weiss added, may have medical implications beyond blood cell development. "This finding does not have immediate clinical application for patients with blood diseases, but it sheds light on how microRNAs fine tune physiological functions in different contexts," said Weiss. FoxO3 regulates anti-oxidant functions in heart cells and also acts as a tumor suppressor, so miR-451 may have an important role in heart protection and in fighting cancers. "Further studies may broaden our knowledge of how this microRNA may defend the body against disease," he added.


'/>"/>

Contact: John Ascenzi
Ascenzi@email.chop.edu
267-426-6055
Children's Hospital of Philadelphia
Source:Eurekalert

0

GOOD

Page: 1 2

Related biology news :

1. Rare and common genetic variations responsible for high triglyceride levels in blood
2. Noninvasive MR imaging of blood vessel growth in tumors using nanosized contrast agents
3. UT MD Anderson study ties abnormal cells in blood to lung cancer
4. Adaptation in mole blood aids tunnelling
5. Toward making extended blood group typing more widely available
6. Pitt researchers find new proteins that regulate blood pressure, flow
7. For lambs, a pasture a week keeps blood suckers away
8. Waters unexpected role in blood pressure control
9. Reprogrammed human blood cells show promise for disease research
10. Cheap, simple, noninvasive blood test may replace invasive diagnostic techniques in early pregnancy
11. Dark chocolate lowers blood pressure
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/16/2013)... decades, scientists have used ancient shorelines to predict the stability ... of a high shoreline from three million years ago, for ... were thought to be evidence of a high sea ... assumption has led many scientists to think that if the ... may do just the same in our modern, progressively warming ...
(Date:5/16/2013)... cellular layer lining the body,s blood vessels, is ... in thickness, this super-tenuous structure routinely withstands blood ... create a unique and highly dynamic barrier that ... the body,s circulatory system. , It,s also extremely ... physically breached to enable immune cells to ...
(Date:5/16/2013)... S.C. , May 16, 2013 ... in combination with a custom thin film transistor ... highest forensic quality roll image in the smallest ... today. Sherlock, an Appendix F Mobile ID FAP ... a 95% reduction in size and weight when ...
Breaking Biology News(10 mins):World's biggest ice sheets likely more stable than previously believed 2Endothelium, heal thyself 2Endothelium, heal thyself 3Endothelium, heal thyself 4
... flu interventions must be imposed quickly, if they are ... journal BMC Public Health have shown that ... within the home should reduce infection, but only if ... maintained for a relatively long period. Professor George ...
... that appears not only to be central to the ... a role in muting the high from methamphetamine and ... known as organic cation transporter 3 or oct3, fills ... damage that causes symptoms like tremor, stiffness, slowness of ...
... -- Arizona State University will be home to a new ... in conjunction with a speech delivered by President Barack Obama. ... will pursue advanced scientific research on solar energy conversion based ... capture sunlight and convert it to useful energy. All 46 ...
Cached Biology News:Social separation stops flu spread, but must be started soon 2Brain protein central to both Parkinson's, drug addiction identified 2Brain protein central to both Parkinson's, drug addiction identified 3Brain protein central to both Parkinson's, drug addiction identified 4DOE funds bio-inspired solar fuel center at Arizona State 2DOE funds bio-inspired solar fuel center at Arizona State 3DOE funds bio-inspired solar fuel center at Arizona State 4
(Date:5/17/2013)... IAC Industries wants to share with you the success ... set up and furnish a research lab knowing that the ... year’s time. How does a company make choices in lab ... is efficient and cost-effective? , The solution was the ... planners at DisperSol determined that the concept of modular lab ...
(Date:5/16/2013)... 2013 ISPE announced ... CAE, to the newly created position of Vice ... Myers will be responsible for stimulating ISPE’s revenue ... advancing the Society’s Member-led and staff-driven business model, ... refine organizational, membership and product marketing. , “Barbara ...
(Date:5/16/2013)... (PRWEB) May 16, 2013 A ... portable models, from Cole-Parmer is designed to meet ... line includes: , The new Cole-Parmer® MS-3400 ... workhorses in the lab. They ensure a powerful ... plasma specimen separation. Their standard four-place swinging buckets ...
(Date:5/16/2013)...  HealthSparq, a trusted provider of healthcare transparency ... health plans, will debut a new benchmark study ... 2013 conference on June 13.  The presentation will ... insurance companies across the country are thinking about ... for increased healthcare transparency. This ...
Breaking Biology Technology:New Downloadable Success Story: “How To Outfit a Dynamic Lab in Flux” 2ISPE Names Barbara A. Myers, CAE, as Vice President of Professional Development 2Cole-Parmer Offers Enhanced Selection of Centrifuges 2HealthSparq to Reveal New Healthcare Transparency Benchmark Study at AHIP Institute 2013 2HealthSparq to Reveal New Healthcare Transparency Benchmark Study at AHIP Institute 2013 3
... ALTO, Calif., Sept. 27 CV Therapeutics,Inc. (Nasdaq: ... has submitted a,supplemental new drug application (sNDA) to ... expansion to the approved product labeling,for Ranexa(R) (ranolazine ... new indication for first line treatment,of chronic angina ...
... 27 Cattle producers,soon will find that the latest ... safe are as close at hand as their desktop ... is leading to the creation of,software that will help ... production medicine at K-State,s College of,Veterinary Medicine, is involved ...
... of strategic plan, WATERTOWN, Mass., Sept. 27 ... Boston Biomedical Research Institute, an independent,not-for- profit biomedical ... new scientists, a 23% increase in its scientific ... the fruits of a three-year,strategic planning process designed ...
Cached Biology Technology:CV Therapeutics Submits Supplemental New Drug Application for Ranexa(R) (ranolazine extended-release tablets) 2K-State Research Leading to Software to Help Nation's Cattle Producers Identify Biosecurity Risks, Evaluate Impact of Cow-Calf Diseases Online 2New Scientists Boost Disease-based Research at Boston Biomedical Research Institute 2New Scientists Boost Disease-based Research at Boston Biomedical Research Institute 3
... assay for mitochondrial membrane potential detection ... are detected by carboxyfluorescein (FAM)-labelled fluoromethylketone ... non-cytotoxic and bind covalently to the ... the same time the mitochondrial membrane ...
... cells were cultured in DMEM and harvested at ... to keep the antigens in their native forms, ... are arrayed on a 12-well (5 mm) adhesive ... to enhance cellular attachment and to minimize background ...
... CopyControl™ vector can be induced prior to ... provide the stability of single-copy BACs with ... other cloning vectors. The kits provide the ... insert size screening system) necessary to create ...
Screening assay to detect the Listeria monocytogenes in food samples by,DNA amplification and molecular hybridization on a microtiter plate....
Biology Products: