Navigation Links
Red alert: Body kills 'spontaneous' blood cancers on a daily basis
Date:2/2/2014

Immune cells undergo 'spontaneous' changes on a daily basis that could lead to cancers if not for the diligent surveillance of our immune system, Melbourne scientists have found.

The research team from the Walter and Eliza Hall Institute found that the immune system was responsible for eliminating potentially cancerous immune B cells in their early stages, before they developed into B-cell lymphomas (also known as non-Hodgkin's lymphomas). The results of the study were published today in the journal Nature Medicine.

This immune surveillance accounts for what researchers at the institute call the 'surprising rarity' of B-cell lymphomas in the population, given how often these spontaneous changes occur. The discovery could lead to the development of an early-warning test that identifies patients at high risk of developing B-cell lymphomas, enabling proactive treatment to prevent tumours from growing.

Dr Axel Kallies, Associate Professor David Tarlinton, Dr Stephen Nutt and colleagues made the discovery while investigating the development of B-cell lymphomas.

Dr Kallies said the discovery provided an answer to why B-cell lymphomas occur in the population less frequently than expected. "Each and every one of us has spontaneous mutations in our immune B cells that occur as a result of their normal function," Dr Kallies said. "It is then somewhat of a paradox that B cell lymphoma is not more common in the population.

"Our finding that immune surveillance by T cells enables early detection and elimination of these cancerous and pre-cancerous cells provides an answer to this puzzle, and proves that immune surveillance is essential to preventing the development of this blood cancer."

B-cell lymphoma is the most common blood cancer in Australia, with approximately 2800 people diagnosed each year and patients with a weakened immune system are at a higher risk of developing the disease.

The research team made the discovery while investigating how B cells change when lymphoma develops. "As part of the research, we 'disabled' the T cells to suppress the immune system and, to our surprise, found that lymphoma developed in a matter of weeks, where it would normally take years," Dr Kallies said. "It seems that our immune system is better equipped than we imagined to identify and eliminate cancerous B cells, a process that is driven by the immune T cells in our body."

Associate Professor Tarlinton said the research would enable scientists to identify pre-cancerous cells in the initial stages of their development, enabling early intervention for patients at risk of developing B-cell lymphoma.

"In the majority of patients, the first sign that something is wrong is finding an established tumour, which in many cases is difficult to treat" Associate Professor Tarlinton said. "Now that we know B-cell lymphoma is suppressed by the immune system, we could use this information to develop a diagnostic test that identifies people in early stages of this disease, before tumours develop and they progress to cancer. There are already therapies that could remove these 'aberrant' B cells in at-risk patients, so once a test is developed it can be rapidly moved towards clinical use."


'/>"/>

Contact: Penny Fannin
fannin@wehi.edu.au
61-417-125-700
Walter and Eliza Hall Institute
Source:Eurekalert  

Related biology news :

1. Media alert: Society of Interventional Radiologys Annual Scientific Meeting
2. Webcast alert: Molecular Medicine Institute to give new hope to pediatric patients
3. MARC travel awards announced for the APS 2014 Professional Skills Training Course
4. Blue light phototherapy kills antibiotic-resistant bacteria, according to new studies
5. LSUHSC research finds combo of plant nutrients kills breast cancer cells
6. Natura Therapeutics product shown to improve decision making skills in older adults
7. UAlberta medical researchers discover how immune system kills healthy cells
8. Ingredient in turmeric spice when combined with anti-nausea drug kills cancer cells
9. First dual-action compound kills cancer cells, stops them from spreading
10. US and French long-term ecological research networks agree to share knowledge and skills
11. Higher-math skills entwined with lower-order magnitude sense
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Red alert: Body kills 'spontaneous' blood cancers on a daily basis
(Date:4/18/2017)... April 18, 2017  Socionext Inc., a global expert in SoC-based ... edge server, the M820, which features the company,s hybrid codec technology. ... by Tera Probe, Inc., will be showcased during the upcoming Medtec ... show at the Las Vegas Convention Center ... Click here ...
(Date:4/13/2017)... April 13, 2017 According to a new market ... Identity Analytics, Identity Administration, and Authorization), Service, Authentication Type, Deployment Mode, Vertical, ... Market is expected to grow from USD 14.30 Billion in 2017 to ... of 17.3%. ... MarketsandMarkets Logo ...
(Date:4/11/2017)... 11, 2017 No two people are ... the New York University Tandon School of Engineering ... found that partial similarities between prints are common ... mobile phones and other electronic devices can be ... vulnerability lies in the fact that fingerprint-based authentication ...
Breaking Biology News(10 mins):
(Date:7/17/2017)... ... July 17, 2017 , ... Co-Diagnostics, Inc. (NASDAQ: ... intends both to manufacture and sell reagents used for diagnostic tests, has completed ... Headquartered in Sandy, Utah, Co-Diagnostics’ intellectual property and technologies are protected by five ...
(Date:7/15/2017)... Staten Island, NY (PRWEB) , ... July 15, 2017 , ... ... field for over 5 years. During this time, the people at FFS have ... learning from their customers, engineers at FFS are able to launch new products to ...
(Date:7/14/2017)... ... July 14, 2017 , ... Diagenode ... of proteins to clean peptides for mass spectrometry (MS) analysis combining the PreOmics ... PreOmics iST Kit is based on proprietary technology that contains optimized buffer systems ...
(Date:7/13/2017)... ... 13, 2017 , ... FireflySci Inc. started manufacturing calibration standards ... years and now they are home to a tremendous line of certified calibration ... resolution testing. , One mega advantage that FireflySci brings to the ...
Breaking Biology Technology: