Navigation Links
Recycling of Alzheimer's proteins could be key to new treatments
Date:5/25/2011

The formation of abnormal strands of protein called amyloid fibrils associated with two dozen diseases ranging from Alzheimer's to type-2 diabetes may not be permanent and irreversible as previously thought, scientists are reporting in the Journal of the American Chemical Society. Rather, protein molecules are constantly attaching and detaching from the fibrils, in a recycling process that could be manipulated to yield new treatments for Alzheimer's and other diseases.

In a study that focused on the fibrils associated with Alzheimer's disease (AD), Natlia Carulla and colleagues explain that scientists once believed that the fibrils themselves caused the memory loss and other symptoms of AD. During the last 10 years, however, suspicion has fallen on some toxic intermediate of the process through which those fibrils form in the brain. This study suggests that fibrils could be a source of those toxic intermediates.

The new study used laboratory techniques to detail molecular recycling within fibrils formed by two proteins, Aβ40 and Aβ42, which is most associated with AD. After monitoring recycling for 40 days, they found that both Aβ40 and Aβ42 molecules recycle within the fibril population, although to different extents. After 40 days, 80 percent of the molecules making up Aβ40 fibrils underwent recycling while only 30 percent did so in Aβ42 fibrils. These observations imply that Aβ42 recycles more slowly.

"In the context of AD, demonstrating that recycling occurs in the fibrils is a step forward but it is also crucial to identify the recycling species involved; whether they are individual Aβ units or small aggregates made of several units," explains Carulla. "It will be important to address if differences in the recycling species within Aβ40 and Aβ42 fibrils are relevant in the development of Alzheimer's disease. We are now working towards this aim. Once we have this information, we will be in a position to devise new therapeutic strategies that can modulate recycling."


'/>"/>

Contact: Michael Bernstein
m_bernstein@acs.org
202-872-6042
American Chemical Society
Source:Eurekalert

Related biology news :

1. TECNALIA uses artificial vision to improve recycling of electronic scrap metal
2. Researchers identify a new gene involved in autophagy, the cellular recycling program
3. Opening the gate to the cells recycling center
4. Scientists concerned about environmental impact of recycling of e-waste
5. Your body recycling itself -- captured on film
6. Industry honors plastics recycling and reactive polymer processing expert at NJIT
7. Carnegie Mellon researchers discover mechanism for signaling receptor recycling
8. Spanish cities fail to meet legal requirements on paper and container recycling
9. Molecule that spurs cells recycling center may help Alzheimers patients
10. Recycling perlite: New, improved method saves resources
11. Neurimmune Therapeutics Announces Advancement of Alzheimers Program into Preclinical Development
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/23/2016)... 2016 Einzigartige ... und Stimmerkennung mit Passwörtern     ... MESG ), ein führender Anbieter digitaler Kommunikationsdienste, ... SpeechPro zusammenarbeitet, um erstmals dessen Biometrietechnologie einzusetzen. ... Möglichkeit angeboten, im Rahmen mobiler Apps neben ...
(Date:3/17/2016)... LONDON , March 17, 2016 ... market intelligence, forecasts the global biometrics market will ... an impressive 118% increase from 2015. Consumer electronics, ... with embedded fingerprint sensors anticipated to reach two ... Dimitrios Pavlakis , Research Analyst ...
(Date:3/11/2016)... Germany , March 11, 2016 http://www.apimages.com ... - Cross reference: Picture is available at AP Images ( http://www.apimages.com ... from DERMALOG will be used to produce the new refugee identity ... other biometric innovations, at CeBIT in Hanover ... scanner from DERMALOG will be used to produce the new refugee ...
Breaking Biology News(10 mins):
(Date:5/23/2016)... (PRWEB) , ... May 23, 2016 , ... ... interest organization focused on molecular nanotechnology, announced the winners for the 2015 Foresight ... physicist Richard Feynman, are given in two categories, one for experiment and the ...
(Date:5/20/2016)... , ... May 20, 2016 , ... Kablooe Design, a ... companies, today announced its official 25th anniversary of the business. “We have worked hard ... grateful to our customers for the privilege and honor of serving their product design ...
(Date:5/19/2016)... ... , ... Anton Paar USA, located in Ashland, Virginia is pleased to announce ... structure adds a third office building to the current facilities. , Growth is ... land, along with office space adjacent to the previous main building. Through remodels and ...
(Date:5/19/2016)... ... May 19, 2016 , ... ... (CRO) has welcomed Abu Siddiqui as Director, Large Molecule & Biomarker Bioanalysis. , ... vaccine and translational biomarker discovery studies for preclinical and clinical safety programs. “We’ve ...
Breaking Biology Technology: