Navigation Links
Recycling of Alzheimer's proteins could be key to new treatments
Date:5/25/2011

The formation of abnormal strands of protein called amyloid fibrils associated with two dozen diseases ranging from Alzheimer's to type-2 diabetes may not be permanent and irreversible as previously thought, scientists are reporting in the Journal of the American Chemical Society. Rather, protein molecules are constantly attaching and detaching from the fibrils, in a recycling process that could be manipulated to yield new treatments for Alzheimer's and other diseases.

In a study that focused on the fibrils associated with Alzheimer's disease (AD), Natlia Carulla and colleagues explain that scientists once believed that the fibrils themselves caused the memory loss and other symptoms of AD. During the last 10 years, however, suspicion has fallen on some toxic intermediate of the process through which those fibrils form in the brain. This study suggests that fibrils could be a source of those toxic intermediates.

The new study used laboratory techniques to detail molecular recycling within fibrils formed by two proteins, Aβ40 and Aβ42, which is most associated with AD. After monitoring recycling for 40 days, they found that both Aβ40 and Aβ42 molecules recycle within the fibril population, although to different extents. After 40 days, 80 percent of the molecules making up Aβ40 fibrils underwent recycling while only 30 percent did so in Aβ42 fibrils. These observations imply that Aβ42 recycles more slowly.

"In the context of AD, demonstrating that recycling occurs in the fibrils is a step forward but it is also crucial to identify the recycling species involved; whether they are individual Aβ units or small aggregates made of several units," explains Carulla. "It will be important to address if differences in the recycling species within Aβ40 and Aβ42 fibrils are relevant in the development of Alzheimer's disease. We are now working towards this aim. Once we have this information, we will be in a position to devise new therapeutic strategies that can modulate recycling."


'/>"/>

Contact: Michael Bernstein
m_bernstein@acs.org
202-872-6042
American Chemical Society
Source:Eurekalert

Related biology news :

1. TECNALIA uses artificial vision to improve recycling of electronic scrap metal
2. Researchers identify a new gene involved in autophagy, the cellular recycling program
3. Opening the gate to the cells recycling center
4. Scientists concerned about environmental impact of recycling of e-waste
5. Your body recycling itself -- captured on film
6. Industry honors plastics recycling and reactive polymer processing expert at NJIT
7. Carnegie Mellon researchers discover mechanism for signaling receptor recycling
8. Spanish cities fail to meet legal requirements on paper and container recycling
9. Molecule that spurs cells recycling center may help Alzheimers patients
10. Recycling perlite: New, improved method saves resources
11. Neurimmune Therapeutics Announces Advancement of Alzheimers Program into Preclinical Development
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/7/2016)... , June 7, 2016  Syngrafii Inc. ... a business relationship that includes integrating Syngrafii,s patented ... branch project. This collaboration will result in greater ... the credit union, while maintaining existing document workflow ... http://photos.prnewswire.com/prnh/20160606/375871LOGO ...
(Date:6/1/2016)... 2016 Favorable Government Initiatives Coupled ... Criminal Identification to Boost Global Biometrics System Market Through ... Research report, " Global Biometrics Market By Type, ... Opportunities, 2011 - 2021", the global biometrics market is ... account of growing security concerns across various end use ...
(Date:5/9/2016)... , UAE, May 9, 2016 ... it comes to expanding freedom for high net worth ... Even in today,s globally connected world, there is still ... system could ever duplicate sealing your deal with a ... second passports by taking advantage of citizenship via investment ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... CLEVELAND , June 27, 2016  Global ... average 4.6 percent through 2020 to $7.2 billion.  ... (food and beverages, cleaning products, biofuel production, animal ... and biotechnology, diagnostics, and biocatalysts). Food and beverages ... gains driven by increasing consumption of products containing ...
(Date:6/27/2016)... ... June 27, 2016 , ... Newly created ... and solutions to the healthcare market. The company's primary focus is on new ... and marketing strategies that are necessary to help companies efficiently bring their products ...
(Date:6/24/2016)... , June 24, 2016 Epic ... sensitively detects cancers susceptible to PARP inhibitors by ... tumor cells (CTCs). The new test has already ... therapeutics in multiple cancer types. Over ... DNA damage response pathways, including PARP, ATM, ATR, ...
(Date:6/23/2016)... CAMBRIDGE, Mass. , June 23, 2016 /PRNewswire/ ... the development of novel compounds designed to target ... compound, napabucasin, has been granted Orphan Drug Designation ... in the treatment of gastric cancer, including gastroesophageal ... cancer stemness inhibitor designed to inhibit cancer stemness ...
Breaking Biology Technology: