Navigation Links
Recreational use of HIV antiretroviral drug linked to its psychoactivity
Date:4/21/2013

ribed how pills used to treat HIV were being crushed and the powder smoked for its psychoactive effects. Though there were no scientific studies on the topic, Dr. Schetz was aware of studies describing neuropsychiatric side effects in HIV patients taking the medication as prescribed, as well as case reports of sudden onset adverse psychiatric events in patients with no history of mental illness. However, research study results suggested that the later patient population were genetically predisposed because they have less effective variants of the enzyme primarily responsible for metabolizing efavirenz, leading to much slower than expected breakdown of efavirenz, and consequently higher than expected levels of drug in the body. Dr. Schetz initiated his investigation with molecular profiling of the receptor pharmacology of efavirenz which lead to the pinpointing of interactions with multiple established sites of action for other known drugs of abuse. He and a number of his colleagues worked together to achieve a pre-clinical understanding of the psychoactivity induced by efavirenz that may help explain reports both of its adverse neuropsychiatric side effects in HIV patients and of its diversion for recreational use.

Dr. Schetz's work is the first ever study of the mechanisms of efavirenz's psychopharmacology and these new findings will help stimulate interest to support additional research related to the mechanism of ARV side effects and abuse potential. This would help translate the pre-clinical findings into preventative measures addressing HIV medication-induced adverse side effects in patients living with HIV. Additionally, preventative strategies would improve patient adherence and quality of life, reduce the potential risk for the emergence of HIV drug resistant strains, and could prevent diversion of HIV medication for illicit use."

His findings will be presented April 21, 2012 during Experimental Biology 2013 in Boston, MA.


'/>"/>

Contact: Jim Bernstein
jbernstein@aspet.org
301-646-3259
Federation of American Societies for Experimental Biology
Source:Eurekalert

Page: 1 2

Related biology news :

1. Early antiretroviral treatment reduces viral reservoirs in HIV-infected teens
2. Scientists find ethnicity linked to antibodies
3. A proteins well-known cousin sheds light on its gout-linked relative
4. Microorganisms detected via breath test linked to body mass, fat accumulation
5. Genetic alterations linked with bladder cancer risk, recurrence, progression, and patient survival
6. Global nitrogen availability consistent for past 500 years, linked to carbon levels
7. Reward linked to image is enough to activate brains visual cortex
8. Kids consumption of sugared beverages linked to higher caloric intake of food
9. Prenatal exposure to pesticide DDT linked to adult high blood pressure
10. 2 new genes linked to amyotrophic lateral sclerosis and related disorders
11. MBL scientists find genes linked to human neurological disorders in sea lamprey genome
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/10/2014)... 8, 2014 You,ve been here before: you desperately ... remember your password, site key or the answer to your ... grade teacher? Today, Hoyos Labs , ... that will finally put an end to the frustration that ... . 1U leverages a user,s smartphone to acquire his ...
(Date:12/10/2014)... , December 9, 2014 ... ITN,s BCARD Platform   ... enterprise meeting scheduling solutions for business-to-business (B2B) events, ... world leader in mobile near-field communication (NFC), Bluetooth ...      (Logo: http://photos.prnewswire.com/prnh/20140612/691055) , Jifflenow ...
(Date:12/3/2014)... As part of our commitment to offering ... to announce the release of a new reader that ... workforce data that they need. The Atlas ... existing readers. Many such devices have serious shortcomings when ... Older models force users to navigate numerous complicated steps ...
Breaking Biology News(10 mins):The Password is Finally Dead: Launch of 1U Mobile App Eliminates Need for All Usernames and Passwords 2The Password is Finally Dead: Launch of 1U Mobile App Eliminates Need for All Usernames and Passwords 3Jifflenow And ITN International Bring Cutting-Edge Badge Scanning Technology To B2B Events 2Jifflenow And ITN International Bring Cutting-Edge Badge Scanning Technology To B2B Events 3Inception Technologies to Release New Biometric Reader 2
... from around the globe issued joint statements today to ... and innovation can play in the pursuit of sustainable ... threat of drug resistance in infectious agents including tuberculosis. ... leaders attending next month,s G8 Summit and other international ...
... exams might want to wait before pulling an all-night ... neurons are concerned. Carnegie Mellon University neuroscientists have discovered ... repeated exposure to a stimulus shrinks synapses. The findings ... Journal of Neuroscience . It,s well known ...
... by an international team of psychologists has shown that ... in brain activity guilt detection tests. Such tests, ... used by law enforcement agencies in several countries, including ... criminals will have specific memories of their crime stored ...
Cached Biology News:Science academies issue 'G-Science' statements to call world leaders' attention to global challenges 2Carnegie Mellon neuroscientists discover new phase of synaptic development 2People can 'beat' guilt detection tests by suppressing incriminating memories 2
(Date:12/24/2014)... NEW YORK , Dec. 24, 2014 ... biopharmaceutical company advancing patient care in critical areas, announced ... shares of common stock, and warrants to purchase up ... an offering price of $4.00 per share and $.01 ... price of $5.00, are exercisable immediately, and expire 5 ...
(Date:12/24/2014)... 23, 2014 GMO corn cases filed ... Syngenta, are in the process of being consolidated in ... case is In Re: Syngenta AG MIR 162 Corn ... for the District of Kansas. , Management of the ... over to U.S. District Judge John W. Lungstrum.* , ...
(Date:12/24/2014)... 23, 2014 According to Ross Selinger, President ... of ITRA Global, the national office market continues to be ... This is evidenced by the third quarter’s surprising 3.9% GDP, ... Low energy costs have held inflation down and the Fed ... the housing market remaining soft. , This solid economic news ...
(Date:12/24/2014)... Diego, CA (PRWEB) December 23, 2014 ... where their Twitter followers can submit their #HolidayInTheLab ... themselves and their lab mates. , For those struggling ... lab mates, the Pipette.com Holiday in the Lab Contest ... Pipette.com Twitter followers to send pictures of ...
Breaking Biology Technology:PlasmaTech Biopharmaceuticals, Inc. Announces Closing of Public Offering 2PlasmaTech Biopharmaceuticals, Inc. Announces Closing of Public Offering 3Carey Danis & Lowe Reports on Syngenta GMO Corn Transfer Order 2ITRA Global Reports Long Island Is Out of Sync With The National Office Market 2ITRA Global Reports Long Island Is Out of Sync With The National Office Market 3Major Pipette Distributor Pipette.com Announces their Holiday in the Lab Contest 2
... Avantium Technologies announces the,launch of a new system to ... be marketed under the name,Crystalline. , ... need in the pharma,industry to learn as much as ... , "Avantium is proud to ...
... Cell Biosciences, Inc., a,provider of nanoproteomic analysis ... of its first kits for the analysis of ... The new kits are,optimized for characterization of proteins ... roles in cancer cell survival and proliferation. Drug ...
... for DNA-Guided Decision Support in Diabetes Drug TherapyHARTFORD, ... shown statistically significant associations of certain genes in ... (BMI) and edema (fluid retention) in patients taking ... study, co-authored with investigators from Joslin Diabetes Center ...
Cached Biology Technology:Avantium Launches the Crystalline, a New Parallel System for Crystallization Research 2Cell Biosciences Introduces Kits for Oncoprotein Analysis 2Cardiovascular Side Effects of Pioglitazone and Rosiglitazone Linked to Vascular and Energy Pathways by Genomas Clinical Study 2
Reacts with methylated DNA from plants and vertebrates...
Mouse monoclonal [GB3] to Kalinin ( Abpromise for all tested applications). entrezGeneID: 3918 SwissProtID: Q13753...
Rabbit polyclonal to Tryptophanyl tRNA synthetase ( Abpromise for all tested applications). Antigen: Recombinant full length protein (Human): Tryptophanyl tRNA synthetase Entrez Gene ID: 745...
Mouse monoclonal [CIa] to Ia Antigen (Biotin) ( Abpromise for all tested applications)....
Biology Products: