Navigation Links
Recombinant adenovirus-mediated DHCR24 inhibits neural apoptosis
Date:8/22/2014

3β-Hydroxysteroid-Δ24 reductase (DHCR24) is a multifunctional enzyme that localizes to the endoplasmic reticulum and has neuroprotective and cholesterol-synthesizing activities. DHCR24 overexpression confers neuroprotection against apoptosis caused by amyloid β deposition. Dr. Xiuli Lu and colleagues from Liaoning University in China constructed two recombinant adenoviruses (Ad-rSYN1-DHCR24-myc and Ad-hSYN1-DHCR24-myc) that drive DHCR24 expression specifically in neuronal cells. They also found that adenovirus transfection inhibits apoptosis through scavenging excess reactive oxygen species. In summary, these researchers have for the first time successfully constructed an adenovirus that induces DHCR24 specifically in neuronal cells. These findings published in the Neural Regeneration Research will lay the foundation for further studies on DHCR24 gene therapy and neuronal functional research in animal models.


'/>"/>

Contact: Meng Zhao
eic@nrren.org
86-138-049-98773
Neural Regeneration Research
Source:Eurekalert  

Page: 1

Related biology news :

1. Baxter Completes Enrollment In Phase III Clinical Trial Of BAX 855, Extended Half-life Recombinant FVIII For Hemophilia A
2. Biomedical Advanced Research and Development Authority (BARDA) Exercises Option with Pfenex Inc. To Extend Contract and Increase Funding for the Development of a Recombinant Protective Antigen (rPA) Based Anthrax Vaccine
3. Malaria medicine chloroquine inhibits tumor growth and metastases
4. Moose drool inhibits growth of toxic fungus: York U research
5. Somatosensory stimulation inhibits excitability of pyramidal cells in rat hippocampal CA1
6. Acidic tumor pH inhibits drug effect
7. Gabapentin inhibits central sensitization during migraine
8. How the Parkin enzyme inhibits neuronal cell death
9. Active component from wine-processed Fructus corni inhibits hippocampal neuron apoptosis
10. Gene transduction inhibits post-epileptic hippocampal synaptic reconstruction
11. New agent inhibits HCV replication in mouse models -- No resistance seen
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Recombinant adenovirus-mediated DHCR24 inhibits neural apoptosis
(Date:3/2/2017)... -- Summary This report provides all the ... its partnering interests and activities since 2010. Download ... Partnering Deals and Alliance since 2010 report provides an ... the world,s leading life sciences companies. On ... inclusion of the most up to date deal and ...
(Date:3/1/2017)... , March 1, 2017  Aware, Inc. (NASDAQ: ... announced that Richard P. Moberg has resigned, ... co-President and Chief Financial Officer and Treasurer of Aware ... to serve as a member of the Board of ... , Aware,s co-Chief Executive Officer and co-President, General Counsel ...
(Date:2/28/2017)... , Spanien, 27. Februar 2017  EyeLock LLC, ... Iris-Scan, wird seine erstklassige biometrische Lösung zur ... 835 mit X16 LTE auf dem Mobile ... März) am Qualcomm-Stand in Halle 3, Stand ... beinhaltet die Sicherheitsplattform Qualcomm Haven™ – eine ...
Breaking Biology News(10 mins):
(Date:3/29/2017)... , Mar 29, 2017 Research and Markets ... Analysis & Trends - Industry Forecast to 2025" report to ... ... CAGR of around 7.8% over the next decade to reach approximately ... the market estimates and forecasts for all the given segments on ...
(Date:3/29/2017)... /PRNewswire/ -  GeneNews Limited (TSX:GEN) ("GeneNews" or the "Company") ... risk stratification test for breast cancer, via its ... BreastSentry incorporates a blood-based biomarker test with a sophisticated algorithm ... breast cancer.   ... BreastSentry measures the fasting plasma levels of two ...
(Date:3/28/2017)... ... March 28, 2017 , ... Today, ... Advancement of Science (AAAS), the world's largest general scientific society and publisher ... scholarly collection across its cross-platform reference management system. , All six Science-branded ...
(Date:3/28/2017)... ... 28, 2017 , ... Franz Inc ., the leading supplier of Semantic ... named a ‘Champion’ by Bloor Research in its recent Graph Database Market Update ... and, thanks to Gruff, it was rated as the easiest product to use.” – ...
Breaking Biology Technology: