Navigation Links
Recombinant adenovirus-mediated DHCR24 inhibits neural apoptosis
Date:8/22/2014

3β-Hydroxysteroid-Δ24 reductase (DHCR24) is a multifunctional enzyme that localizes to the endoplasmic reticulum and has neuroprotective and cholesterol-synthesizing activities. DHCR24 overexpression confers neuroprotection against apoptosis caused by amyloid β deposition. Dr. Xiuli Lu and colleagues from Liaoning University in China constructed two recombinant adenoviruses (Ad-rSYN1-DHCR24-myc and Ad-hSYN1-DHCR24-myc) that drive DHCR24 expression specifically in neuronal cells. They also found that adenovirus transfection inhibits apoptosis through scavenging excess reactive oxygen species. In summary, these researchers have for the first time successfully constructed an adenovirus that induces DHCR24 specifically in neuronal cells. These findings published in the Neural Regeneration Research will lay the foundation for further studies on DHCR24 gene therapy and neuronal functional research in animal models.


'/>"/>

Contact: Meng Zhao
eic@nrren.org
86-138-049-98773
Neural Regeneration Research
Source:Eurekalert  

Page: 1

Related biology news :

1. Baxter Completes Enrollment In Phase III Clinical Trial Of BAX 855, Extended Half-life Recombinant FVIII For Hemophilia A
2. Biomedical Advanced Research and Development Authority (BARDA) Exercises Option with Pfenex Inc. To Extend Contract and Increase Funding for the Development of a Recombinant Protective Antigen (rPA) Based Anthrax Vaccine
3. Malaria medicine chloroquine inhibits tumor growth and metastases
4. Moose drool inhibits growth of toxic fungus: York U research
5. Somatosensory stimulation inhibits excitability of pyramidal cells in rat hippocampal CA1
6. Acidic tumor pH inhibits drug effect
7. Gabapentin inhibits central sensitization during migraine
8. How the Parkin enzyme inhibits neuronal cell death
9. Active component from wine-processed Fructus corni inhibits hippocampal neuron apoptosis
10. Gene transduction inhibits post-epileptic hippocampal synaptic reconstruction
11. New agent inhibits HCV replication in mouse models -- No resistance seen
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Recombinant adenovirus-mediated DHCR24 inhibits neural apoptosis
(Date:6/24/2015)... Switzerland , June 24, 2015 ... partnership with emerging biometric password solution one face ... one face in, entering ... a ground-breaking and affordable multifactor-authentication biometric answer to ... recognition technology, provided in partnership with KeyLemon, one ...
(Date:6/23/2015)... Fla. , June 23, 2015 /PRNewswire/ ... management and authentication solutions, today announced enhanced functionality ... multi-factor authentication solution.  The enhancements build on ... of the DigitalPersona Altus platform and provide ... compatibility. In today,s environment of ...
(Date:6/17/2015)... and HILDEN, Germany , June 17, 2015 ... Frankfurt Prime Standard: QIA) today launched new Investigator ® ... laboratories in the United States . The ... analyze multiple key genomic markers (short tandem repeats or STRs) ... Sensor to evaluate the quality of DNA in each sample, ...
Breaking Biology News(10 mins):KeyLemon Announces Partnership With Biometric Password Solution onefacein 2Crossmatch Releases Enhanced DigitalPersona Altus Advanced Authentication Functionality 2QIAGEN Launches New Genetic Fingerprinting Kits for U.S. Forensic Labs 2QIAGEN Launches New Genetic Fingerprinting Kits for U.S. Forensic Labs 3QIAGEN Launches New Genetic Fingerprinting Kits for U.S. Forensic Labs 4QIAGEN Launches New Genetic Fingerprinting Kits for U.S. Forensic Labs 5
... The Van Andel Research Institute (VARI) and the ... alliance that will enable both to maximize their worldwide ... institutes jointly announced today the initiation of an "alliance ... Rapids, Mich.-based VARI and Phoenix, Ariz.-based TGen will enable ...
... to identify microbes that may cause preterm labor in some ... contractions and an early birth, and look at different groups ... prematurity. The work of seven researchers will be supported ... Prematurity Research Initiative (PRI) grants. The nearly $2.7 million ...
... against respiratory infections, the body typically produces a little fluid ... research suggests that the influenza virus can tip the balance ... supply of oxygen to the rest of the body. ... but this research suggests that it,s not the presence of ...
Cached Biology News:Van Andel Research Institute and TGen undertake alliance to promote science and health 2Van Andel Research Institute and TGen undertake alliance to promote science and health 3March of Dimes provides $2.7 million in new funding for preterm birth research 2March of Dimes provides $2.7 million in new funding for preterm birth research 3Study: Fluid buildup in lungs is part of the damage done by the flu 2Study: Fluid buildup in lungs is part of the damage done by the flu 3
(Date:6/29/2015)... , June 29, 2015   Veracyte, Inc . ... the field of molecular cytology, today announced that it ... prestigious Top Workplaces list for the second year in ... based solely on an annual survey of Bay Area-company ... that the degree to which Veracyte values our employees ...
(Date:6/26/2015)... KANSAS CITY, Kan. , June 26, ... (NASDAQ: PETX ), a pet therapeutics ... commercialization of innovative biopharmaceutical products for companion ... pivotal field effectiveness study of capromorelin (AT-002), ... in dogs.  Capromorelin is a small molecule ...
(Date:6/26/2015)... MUMBAI, India , June 26, 2015 ... a leading global IT services, consulting and business solutions ... Leader in Worldwide Life Sciences R&D Risk-Based Monitoring by ... MarketScape: Worldwide Life Science R&D Risk-Based Monitoring 2015 Vendor ... The report evaluated eight leading IT services vendors with ...
(Date:6/26/2015)... 2015 The report "Biolubricants Market ... Metalworking fluids, Chainsaw oils, Mold Release Agents), End Use ... Global trends and Forecasts to 2020" published by MarketsandMarkets, ... by 2020 at a CAGR of 6.27% between 2015 ... Tables and   66 Figures spread through 170 Pages ...
Breaking Biology Technology:Veracyte Named a 2015 "Top Workplace" in the San Francisco Bay Area 2Veracyte Named a 2015 "Top Workplace" in the San Francisco Bay Area 3Aratana Therapeutics Announces Positive Pivotal Results for AT-002 2Aratana Therapeutics Announces Positive Pivotal Results for AT-002 3Aratana Therapeutics Announces Positive Pivotal Results for AT-002 4Aratana Therapeutics Announces Positive Pivotal Results for AT-002 5TCS Recognized as a Leader in Life Sciences R&D Risk-Based Monitoring by IDC MarketScape 2TCS Recognized as a Leader in Life Sciences R&D Risk-Based Monitoring by IDC MarketScape 3TCS Recognized as a Leader in Life Sciences R&D Risk-Based Monitoring by IDC MarketScape 4Biolubricants Market Worth $2,972.13 Million by 2020 2Biolubricants Market Worth $2,972.13 Million by 2020 3
... Application of the RoboCycler Gradient 96 temperature ... , Stratagenes RoboCycler Gradient 96 temperature cycler ... perform fluorescent-tag cycle,sequencing using the ABI PRISM ... Hot Top Assembly eliminates the need for oil or ...
... Allelic discrimination kits with excellent specificity, sensitivity, and,assay ... Lingyu Chen ,Stratagene , Because of their unique ... differences, making them ideal for mutation detection and,allelic ... developed a,series of Mx4000 molecular beacon allelic discrimination ...
... , Douglas Drake Michelle Cayouette Lisa Filippone ,Bob LeSchofs ,Stratagene , , ... , , Figure 1: The ... Stratagene has developed the new SmartPower , ... electrophoretic application. The SmartPower 4000 power supply has been, ...
Cached Biology Technology:Automated Fluorescent-Tag Cycle Sequencing 2Automated Fluorescent-Tag Cycle Sequencing 3Automated Fluorescent-Tag Cycle Sequencing 4Automated Fluorescent-Tag Cycle Sequencing 5Detect Single Nucleotide Sequence Changes with Mx4000 Molecular Beacon,Allelic Discrimination Kits 2Detect Single Nucleotide Sequence Changes with Mx4000 Molecular Beacon,Allelic Discrimination Kits 3Detect Single Nucleotide Sequence Changes with Mx4000 Molecular Beacon,Allelic Discrimination Kits 4Detect Single Nucleotide Sequence Changes with Mx4000 Molecular Beacon,Allelic Discrimination Kits 5Detect Single Nucleotide Sequence Changes with Mx4000 Molecular Beacon,Allelic Discrimination Kits 6Detect Single Nucleotide Sequence Changes with Mx4000 Molecular Beacon,Allelic Discrimination Kits 7A Versatile Power Supply for All Electrophoresis Applications 2A Versatile Power Supply for All Electrophoresis Applications 3A Versatile Power Supply for All Electrophoresis Applications 4A Versatile Power Supply for All Electrophoresis Applications 5
... Amplification Kit, 100 reactions. Prepare circular ... 4-6 h.Generate microgram quantities of template ... material.Use amplified DNA directly for cycle ... or M13 liquid cultures, colonies, plaques, ...
Polypropylene test tube racks, used in Thermo Forma's line of Test Tube Rack holders...
For quantitative determination of Aldolase in Serum (an indicator of muscle damage). Ready-to-use liquid stable reagent. Formulated to eliminate interference from pyruvates. Application sheets are ...
This Universal 24" X 18" (61 X 45.7cm.) shaker platforms will accept any Thermo Forma shaker flask clip....
Biology Products: