Navigation Links
Recombinant adenovirus-mediated DHCR24 inhibits neural apoptosis
Date:8/22/2014

3β-Hydroxysteroid-Δ24 reductase (DHCR24) is a multifunctional enzyme that localizes to the endoplasmic reticulum and has neuroprotective and cholesterol-synthesizing activities. DHCR24 overexpression confers neuroprotection against apoptosis caused by amyloid β deposition. Dr. Xiuli Lu and colleagues from Liaoning University in China constructed two recombinant adenoviruses (Ad-rSYN1-DHCR24-myc and Ad-hSYN1-DHCR24-myc) that drive DHCR24 expression specifically in neuronal cells. They also found that adenovirus transfection inhibits apoptosis through scavenging excess reactive oxygen species. In summary, these researchers have for the first time successfully constructed an adenovirus that induces DHCR24 specifically in neuronal cells. These findings published in the Neural Regeneration Research will lay the foundation for further studies on DHCR24 gene therapy and neuronal functional research in animal models.


'/>"/>

Contact: Meng Zhao
eic@nrren.org
86-138-049-98773
Neural Regeneration Research
Source:Eurekalert  

Page: 1

Related biology news :

1. Baxter Completes Enrollment In Phase III Clinical Trial Of BAX 855, Extended Half-life Recombinant FVIII For Hemophilia A
2. Biomedical Advanced Research and Development Authority (BARDA) Exercises Option with Pfenex Inc. To Extend Contract and Increase Funding for the Development of a Recombinant Protective Antigen (rPA) Based Anthrax Vaccine
3. Malaria medicine chloroquine inhibits tumor growth and metastases
4. Moose drool inhibits growth of toxic fungus: York U research
5. Somatosensory stimulation inhibits excitability of pyramidal cells in rat hippocampal CA1
6. Acidic tumor pH inhibits drug effect
7. Gabapentin inhibits central sensitization during migraine
8. How the Parkin enzyme inhibits neuronal cell death
9. Active component from wine-processed Fructus corni inhibits hippocampal neuron apoptosis
10. Gene transduction inhibits post-epileptic hippocampal synaptic reconstruction
11. New agent inhibits HCV replication in mouse models -- No resistance seen
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Recombinant adenovirus-mediated DHCR24 inhibits neural apoptosis
(Date:6/14/2017)... , June 15, 2017  IBM (NYSE: IBM ) ... international tech event dedicated to developing collaboration between startups and ... on June 15-17. During the event, nine startups will showcase ... value in various industries. France ... the international market, with a 30 percent increase in the ...
(Date:5/6/2017)... 2017 RAM Group , Singaporean ... breakthrough in biometric authentication based on a ... to perform biometric authentication. These new sensors are based ... by Ram Group and its partners. This sensor will ... chains and security. Ram Group is a next ...
(Date:4/17/2017)... NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" ... its 2016 Annual Report on Form 10-K on Thursday April 13, ... ... the Investor Relations section of the Company,s website at http://www.nxt-id.com ... http://www.sec.gov . 2016 Year Highlights: ...
Breaking Biology News(10 mins):
(Date:9/22/2017)... ... September 22, 2017 , ... ... host a booth at premier packaging event PACK EXPO International in Las Vegas ... Machinery Manufacturers Institute (PMMI). , At this year’s PACK EXPO at the Last ...
(Date:9/21/2017)... ... 21, 2017 , ... Dr. Greg Leyer, Chief Scientific Officer of UAS Labs, ... presentation is at 12:10pm in the Probiotics Resource Center, Mandalay Bay Expo Hall. ... discuss how probiotics have shown impressive data in areas outside the gut including heart ...
(Date:9/21/2017)... ... September 21, 2017 , ... When a downtown Greenville portion ... swift and efficient thanks to the continuing efforts of members of the Reedy ... than 50 stakeholders, including officials from area counties and cities, Renewable Water Resources ...
(Date:9/20/2017)... ... 20, 2017 , ... Diversity focused business accelerator, The Refinery , announced ... to uncover the top technology-driven, women-led startups in Boston, MA, New Haven/Hamden, CT, and ... entrepreneurial events going on that week – in Boston, it will be part of ...
Breaking Biology Technology: