Navigation Links
Recombinant adenovirus-mediated DHCR24 inhibits neural apoptosis
Date:8/22/2014

3β-Hydroxysteroid-Δ24 reductase (DHCR24) is a multifunctional enzyme that localizes to the endoplasmic reticulum and has neuroprotective and cholesterol-synthesizing activities. DHCR24 overexpression confers neuroprotection against apoptosis caused by amyloid β deposition. Dr. Xiuli Lu and colleagues from Liaoning University in China constructed two recombinant adenoviruses (Ad-rSYN1-DHCR24-myc and Ad-hSYN1-DHCR24-myc) that drive DHCR24 expression specifically in neuronal cells. They also found that adenovirus transfection inhibits apoptosis through scavenging excess reactive oxygen species. In summary, these researchers have for the first time successfully constructed an adenovirus that induces DHCR24 specifically in neuronal cells. These findings published in the Neural Regeneration Research will lay the foundation for further studies on DHCR24 gene therapy and neuronal functional research in animal models.


'/>"/>

Contact: Meng Zhao
eic@nrren.org
86-138-049-98773
Neural Regeneration Research
Source:Eurekalert  

Page: 1

Related biology news :

1. Baxter Completes Enrollment In Phase III Clinical Trial Of BAX 855, Extended Half-life Recombinant FVIII For Hemophilia A
2. Biomedical Advanced Research and Development Authority (BARDA) Exercises Option with Pfenex Inc. To Extend Contract and Increase Funding for the Development of a Recombinant Protective Antigen (rPA) Based Anthrax Vaccine
3. Malaria medicine chloroquine inhibits tumor growth and metastases
4. Moose drool inhibits growth of toxic fungus: York U research
5. Somatosensory stimulation inhibits excitability of pyramidal cells in rat hippocampal CA1
6. Acidic tumor pH inhibits drug effect
7. Gabapentin inhibits central sensitization during migraine
8. How the Parkin enzyme inhibits neuronal cell death
9. Active component from wine-processed Fructus corni inhibits hippocampal neuron apoptosis
10. Gene transduction inhibits post-epileptic hippocampal synaptic reconstruction
11. New agent inhibits HCV replication in mouse models -- No resistance seen
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Recombinant adenovirus-mediated DHCR24 inhibits neural apoptosis
(Date:6/23/2017)... and ITHACA, N.Y. , June ... Cornell University, a leader in dairy research, today announced ... designed to help reduce the chances that the global ... onset of this dairy project, Cornell University has become ... Sequencing the Food Supply Chain, a food safety initiative ...
(Date:5/23/2017)... 2017  Hunova, the first robotic gym for the rehabilitation and functional ... in Genoa, Italy . The first 30 robots will ... USA . The technology was developed and patented at ... IIT spin-off Movendo Technology thanks to a 10 million euro investment from ... click: ...
(Date:5/16/2017)... 16, 2017   Bridge Patient Portal , ... MD EMR Systems , an electronic medical ... GE, have established a partnership to build an ... the GE Centricity™ products, including Centricity Practice Solution ... These new integrations will allow healthcare delivery ...
Breaking Biology News(10 mins):
(Date:7/17/2017)... ... July 17, 2017 , ... ... solutions, today announced safety software company AB Cube has joined its ... segment to advance technology innovation across life sciences and healthcare. Under the ...
(Date:7/17/2017)... ... , ... Panitch Schwarze Belisario & Nadel intellectual ... Innovation Group) annual meeting in China. , This year’s meeting, held June 9-10 ... a rapidly developing highly personalized anti-cancer technology that involves removing some of a ...
(Date:7/16/2017)... ... July 16, 2017 , ... OHAUS Corporation, ... the launch of its new line of Rocking and Waving Shakers today. , ... models (both analog and digital) for laboratory applications in a variety of environmental ...
(Date:7/14/2017)... ... July 14, 2017 , ... Sonic Manufacturing Technologies is proud ... installed a solar system on its roof top. “We will be independent of ... Kenneth Raab stated. The company’s proud history of social responsibility and participation in ...
Breaking Biology Technology: