Navigation Links
Recipient's immune system governs stem cell regeneration
Date:11/20/2011

A new study in Nature Medicine describes how different types of immune system T-cells alternately discourage and encourage stem cells to regrow bone and tissue, bringing into sharp focus the importance of the transplant recipient's immune system in stem cell regeneration.

The study, conducted at the Center for Craniofacial Molecular Biology at the Ostrow School of Dentistry of USC, examined how mice with genetic bone defects responded to infusions of bone marrow mesenchymal stem cells, or BMMSC.

Under normal conditions, the mice's T-cells produced an inflammatory response and triggered the creation of cellular proteins interferon (INF)-gamma and tumor necrosis factor (TNF)-alpha. These attacked and killed the stem cells, preventing the production of new bone.

"Normally, T-cells protect us from infection," said Professor Songtao Shi, corresponding author for the study, "but they can block healthy regeneration from happening."

However, when the mice were given infusions of regulatory T-cells, or Treg, the levels of the interfering INF-gamma and TNF-alpha decreased, increasing the rate of bone growth and defect repair. Furthermore, administering the anti-inflammatory drug aspirin at the site of the bone defect also increased the rate at which the BMMSCs were able to regrow bone.

Postdoctoral Research Associate and lead author Yi Liu said the findings illustrate the previously unrecognized role of T-cells in tissue regeneration. They also highlight the need for scientists exploring the possibilities of stem cell regeneration to shift their focus to the immune system, she added.

"Based on what we've found, this should be the direction of more research in the future," Liu said.


'/>"/>

Contact: Beth Dunham
bethdunh@usc.edu
213-740-4279
University of Southern California
Source:Eurekalert

Page: 1

Related biology news :

1. US Department of Energy PECASE recipients
2. Biophysical Society names 5 2012 award recipients
3. Recipients of the 2011 Postdoctoral Professional Development and Enrichment Award
4. FASEB MARC program announces the travel award recipients for the 2011 Leadership Development and Grant Writing Seminar for graduate students, postdoctoral fellows and new assistant professors
5. ASPB names 2011 award recipients
6. Pew announces 2011 recipients of distinguished marine conservation fellowship
7. Catherine Dulac, Cori Bargmann are co-recipients of 11th Perl-UNC Neuroscience Prize
8. AACR congratulates recipients of minority-serving institution in cancer research awards
9. 2011 Harold M. Weintraub Graduate Student Award recipients announced
10. Vilcek Foundation names recipients of 2011 Vilcek Prizes in Biomedical Science
11. PNAS announces 6 2010 Cozzarelli Prize recipients
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... Jan. 22, 2015 Infinisource has launched its new NXG ... model. The G2 sets a higher standard for collecting attendance ... management solution. With plug-and-play installation, touch screen interface and seamless ... a robust time collection solution for the small to mid-size ...
(Date:12/19/2014)... 18, 2014 Research and Markets ( http://www.researchandmarkets.com/research/8kmfcn/iphone_5s ... 5S Fingerprint Sensor - Apple/AuthenTec TMDR92 & Sapphire - ... http://photos.prnewswire.com/prnh/20130307/600769 Following the ... fingerprint reading feature with the iPhone 5S. It is ...
(Date:12/17/2014)... Dec. 15, 2014 The Defense Logistics Agency is ... and prevent counterfeit microcircuits from entering into its supply ... in-house microcircuit anti-counterfeit initiative dubbed DNA marking. The capability ... their reliability throughout the supply chain. The new quality ...
Breaking Biology News(10 mins):Infinisource's NXG series sets new time clock standard 2iPhone 5S Fingerprint Sensor - Apple/AuthenTec TMDR92 & Sapphire - Technology Report 2Defense Logistics Agency Launches DNA Marking Capability to Strengthen Microcircuit Supply Chain 2Defense Logistics Agency Launches DNA Marking Capability to Strengthen Microcircuit Supply Chain 3
... parallel studies in human and mouse, two groups of researchers ... of gene is associated with progressive hearing loss. The new ... of RNA that affects the production of hundreds of other ... The research provides important new genetic understanding of a ...
... is widely used in laboratories as a model organism ... Arabidopsis offers researchers several advantages such as ... about only six weeks from seed to seed, easy cultivation ... a professor of biochemistry at UC Riverside, has received a ...
... example as a result of exposure to ionizing radiation, they ... program themselves for death, a process called apoptosis. ... is remarkable, involving what might be described metaphorically as a ... tightly in the cell nucleus. In intricate ways, cells ...
Cached Biology News:New insights into progressive hearing loss 2New insights into progressive hearing loss 3New insights into progressive hearing loss 4UC Riverside biochemist to study how crops can increase protein production 2CSHL-led team identifies key decision-point at which cells with broken DNA repair themselves or die 2CSHL-led team identifies key decision-point at which cells with broken DNA repair themselves or die 3CSHL-led team identifies key decision-point at which cells with broken DNA repair themselves or die 4
(Date:1/23/2015)... BioPharma Inc. (NASDAQ: ARRY ) today announced ... Pharma AG to acquire worldwide rights to encorafenib (LGX818), ... agreement is conditional on the closing of transactions announced by ... are expected to close in the first half of ...
(Date:1/22/2015)... , Jan. 22, 2015  Transwestern | RBJ today announces the ... office space for Shire a leading biopharmaceutical company, at Two ... | RBJ,s Robert Richards , president, and Brian ... for the entire five-floor building at 95 Hayden Ave. ...
(Date:1/22/2015)... laboratory information management systems market is a rapidly growing ... due to factors such as rising pressure to comply ... and increasing government support for adoption of HCIT solutions ... the market focus on technological advancements to further the ...
(Date:1/22/2015)... zFlo Motion , a US leader in biomechanics ... from a new partner. STT-Systems has developed an ... years, with offerings in the optical-motion capture, 3D scanning, and ... measurement unit), iSen, is opening eyes around the world. With ...
Breaking Biology Technology:Array Announces Agreement To Acquire ENCORAFENIB (LGX818) 2Array Announces Agreement To Acquire ENCORAFENIB (LGX818) 3Array Announces Agreement To Acquire ENCORAFENIB (LGX818) 4Array Announces Agreement To Acquire ENCORAFENIB (LGX818) 5Array Announces Agreement To Acquire ENCORAFENIB (LGX818) 6Array Announces Agreement To Acquire ENCORAFENIB (LGX818) 7Transwestern | RBJ Advises Shire in 202,000 SF Lease, Creating Boston's Largest Suburban Biotech Campus 2Laboratory Information Management Systems Market is Expected to Reach $1,323.6 Million by 2019 - New Research Report by MarketsandMarkets 2Laboratory Information Management Systems Market is Expected to Reach $1,323.6 Million by 2019 - New Research Report by MarketsandMarkets 3Laboratory Information Management Systems Market is Expected to Reach $1,323.6 Million by 2019 - New Research Report by MarketsandMarkets 43D Motion Capture Just Got Easy 2
... Reserve University have made an electrochemical cell that uses ... of metal. The technology may open new pathways ... hydrogen fuel and synthesizing nanomaterials and polymers. A ... online edition of the Journal of the American ...
... Oct. 20, 2011 Pharmatech Oncology announces completion of ... project, funded by the National Cancer Institute (NCI).  ... enrollment model called Just-in-Time (JIT) to enroll ... prioritized around detection of patients with qualifying diagnoses across ...
... 2011 -- "Working Toward a Cure: Examining ... in Breast Cancer Research Article Output -- The ... in the publication of breast cancer research articles, according to ... Examining   the State of Global Breast Cancer Research . ...
Cached Biology Technology:Electrochemistry controlled with a plasma electrode 2Pharmatech Oncology Announces Completion of SBIR Grant Research 2United States Holds Global Lead in Breast Cancer Research Publications as China Surges to Forefront, According to Report 2United States Holds Global Lead in Breast Cancer Research Publications as China Surges to Forefront, According to Report 3United States Holds Global Lead in Breast Cancer Research Publications as China Surges to Forefront, According to Report 4United States Holds Global Lead in Breast Cancer Research Publications as China Surges to Forefront, According to Report 5
... GELase™ Agarose Gel-Digesting Preparation contains a unique ... simple, quantitative recovery of intact DNA and ... gels following electrophoresis in TAE, TBE, MOPS, ... digested directly in the TAE, TBE, MOPS, ...
... Perhaps sheer in-house demand is causing shortages ... precious antibody. This can cause unwanted distractions, problems ... royalties for your hard work and endeavour! Bring ... up and market it internationally. We work under ...
... demand is causing shortages in your laboratory ... This can cause unwanted distractions, problems and ... for your hard work and endeavour! Bring ... it up and market it internationally. We ...
... Perhaps sheer in-house demand is causing shortages ... precious antibody. This can cause unwanted distractions, problems ... royalties for your hard work and endeavour! Bring ... up and market it internationally. We work under ...
Biology Products: