Navigation Links
Receptor variant influences dopamine response to alcohol
Date:5/18/2010

A genetic variant of a receptor in the brain's reward circuitry plays an important role in determining whether the neurotransmitter dopamine is released in the brain following alcohol intake, according to a study led by researchers at the National Institute on Alcohol Abuse and Alcoholism (NIAAA), part of the National Institutes of Health. Dopamine is involved in transmitting the euphoria and other positive subjective effects produced by alcohol.

A report of the findings, which help explain the diverse genetic susceptibility for alcohol use disorders, will appear online in Molecular Psychiatry on May 18, 2010.

"By advancing our understanding of the neurobiology that underlies the addictive properties of alcohol, this finding helps us understand why alcohol affects people in very different ways," says NIAAA Acting Director Kenneth R. Warren, Ph.D. "This kind of information also aids the development of personalized medications for alcohol problems."

Receptors for brain molecules known as opioid peptides help initiate the neurochemical reactions that underlie the positive effects produced by alcohol. Activation of the mu-subtype of opioid receptor following alcohol consumption triggers the release of dopamine from the forebrain.

"But there is much variation in alcohol-induced responses that are thought to be related to dopamine," explains Markus Heilig, M.D., Ph.D., NIAAA clinical director and the study's senior author. "Previous studies by our group and others suggest that variants of opioid genes may contribute to the observed variation, possibly through effects on alcohol-induced dopamine release."

He notes, for example, that people who carry the mu-opioid receptor variant designated as 118G report increased euphoria following alcohol consumption. Dr. Heilig's group has reported that a similar mu-opioid receptor variant in monkeys heightened the stimulating effects of alcohol and increased their alcohol c
'/>"/>

Contact: John Bowersox
niaaapressoffice@mail.nih.gov
301-443-3860
NIH/National Institute on Alcohol Abuse and Alcoholism
Source:Eurekalert

Page: 1 2

Related biology news :

1. Gene-based stem cell therapy specifically removes cell receptor that attracts HIV
2. Stress peptide and receptor may have role in diabetes
3. Developmental delay could stem from nicotinic receptor deletion
4. Common herbicides and fibrates block nutrient-sensing receptor found in gut and pancreas
5. Caltech scientists get detailed glimpse of chemoreceptor architecture in bacterial cells
6. Endothelin receptor may play role in sickle cell pain
7. Study reveals a reprogrammed role for the androgen receptor
8. Grant supports LSUHSC research on how like cell receptor systems determine very different functions
9. Flexible neck in cell-receptor DC-SIGN targets more pathogens
10. Scientists explain how death receptors designed to kill our cells may make them stronger
11. Newly discovered epidermal growth factor receptor active in human pancreatic cancers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/16/2015)... , June 16, 2015 /CNW Telbec/ - handyem ... centralized around the incorporation of handyem,s HPC-150 portable ... laboratory, the Mo-POD™. This unprecedented model of mobile ... Conference at the Pennsylvania ... June 15 th to 18 th ...
(Date:6/16/2015)... Fingerprint Cards (FPC) raises the revenue guidance for ... at least 340 MSEK to that it will amount to ... growth and orders received the revenue guidance for 2015 is ... will exceed 1,500 MSEK to an updated guidance that revenue ... Due to receipt of orders of touch fingerprint sensors with ...
(Date:6/15/2015)... Conn. , Jun. 15, 2015 NXT-ID, Inc. (NASDAQ: ... company focused on the growing mobile commerce market, announces that ... be showcased to media at Digital Experience! @ NYC June ... summer showcase of the latest innovation in technology to over ... will be held at the Metropolitan Pavilion in ...
Breaking Biology News(10 mins):handyem and FlowMetric Diagnostics announce their partnership in the development of Flow Cytometry- Based Solutions in diagnostic capabilities 2handyem and FlowMetric Diagnostics announce their partnership in the development of Flow Cytometry- Based Solutions in diagnostic capabilities 3Fingerprint Cards Raises the Revenue Guidance for Q2 2015 and for the Full Year 2015 2Fingerprint Cards Raises the Revenue Guidance for Q2 2015 and for the Full Year 2015 3Wocket Smart Wallet Exhibiting at Pepcom Digital Experience! @ NYC June 18th 2Wocket Smart Wallet Exhibiting at Pepcom Digital Experience! @ NYC June 18th 3
... who have high blood sugar before undergoing surgery ... deep vein thrombosis and even pulmonary embolism after ... anesthesiology in the Artificial Pancreas Center at Jefferson ... and his colleagues examined records of nearly 6,500 ...
... light on how tiny molecular motors that transport materials ... , The knowledge could lead to better understanding of ... such as Down syndrome caused by faulty molecular motors, ... researchers said. For example, molecular motors are responsible for ...
... Two Boston University biomedical engineers have won a ... continue groundbreaking research aimed at reducing the cost ... , Boston University Associate Professor of Biomedical Engineering ... chosen for the NIH's National Human Genome Research ...
Cached Biology News:Jefferson scientists find high glucose before surgery raises risk of dangerous complications 2Researchers image molecular motor structural changes 2Researchers image molecular motor structural changes 3Researchers image molecular motor structural changes 4Boston University biomedical engineers win major grant for pursuit of the '$1,000 Genome' 2
(Date:7/7/2015)... ... July 07, 2015 , ... uBiome, the leading microbial genomics ... of microbiome sampling kits and full 16S laboratory analysis. The goal is to fast-track ... will also have access to their own dashboard, enabling them to view and compare ...
(Date:7/7/2015)... (PRWEB) , ... July 07, 2015 , ... ... membership driven community in the biometrical area. What began as a conference for ... global community for various functions in the biometrical area. Statistical Programmers, Data Managers ...
(Date:7/7/2015)... ... July 07, 2015 , ... Currently deployed ... was developed to solve many of the complex logistical and data management ... involve multiple clinical sites and/or remote data coordination centers. , CentrePoint drastically ...
(Date:7/6/2015)... ... July 06, 2015 , ... An optical ... reveal how blood flows in the brain during stroke, providing information that could ... new article published in the journal Neurophotonics describes work at the ...
Breaking Biology Technology:uBiome to Award Grant of up to $100k for Groundbreaking Microbiome Research 2uBiome to Award Grant of up to $100k for Groundbreaking Microbiome Research 3PhUSE Delighted to Welcome Member Number 5.000 2ActiGraph Launches CentrePoint Cloud-based Study Management Software Platform 2ActiGraph Launches CentrePoint Cloud-based Study Management Software Platform 3Reducing Stroke Damage May be Next Application for OCT Technology Now Widely Used in Eye and Vision Healthcare 2Reducing Stroke Damage May be Next Application for OCT Technology Now Widely Used in Eye and Vision Healthcare 3
... PDL BioPharma, Inc. (PDL, the Company) (NASDAQ: ... to market and other conditions, $135 million aggregate principal amount ... Company,s shelf registration statement filed with the U.S. Securities and ... expects to grant the underwriters a 13-day overallotment option to ...
... The U.S. Food and Drug Administration is requesting input ... of a user fee program for biosimilar and interchangeable ... http://photos.prnewswire.com/prnh/20090824/FDALOGO ) Biological products are produced in ... animal cell, while small molecule drugs are typically made ...
... May 9, 2011 Accuray Incorporated (Nasdaq: ... field of radiosurgery, announced today that the U.S. Securities ... S-4 Registration Statement relating to the previously announced acquisition ... in the registration statement will first be mailed to ...
Cached Biology Technology:PDL BioPharma, Inc. Announces Proposed $135 Million Public Offering of New Convertible Senior Notes Due 2015 2PDL BioPharma, Inc. Announces Proposed $135 Million Public Offering of New Convertible Senior Notes Due 2015 3PDL BioPharma, Inc. Announces Proposed $135 Million Public Offering of New Convertible Senior Notes Due 2015 4PDL BioPharma, Inc. Announces Proposed $135 Million Public Offering of New Convertible Senior Notes Due 2015 5FDA Requests Input on Development of User Fee Program for Biosimilar and Interchangeable Biological Products 2SEC Declares Accuray Form S-4 Registration Statement Effective in Proposed Acquisition of TomoTherapy 2SEC Declares Accuray Form S-4 Registration Statement Effective in Proposed Acquisition of TomoTherapy 3SEC Declares Accuray Form S-4 Registration Statement Effective in Proposed Acquisition of TomoTherapy 4
MOUSE ANTI HUMAN NPM...
RABBIT ANTI HUMAN CHYMOTRYPSIN...
Rat neural stem cell kits are intended for the in vitro growth and commitment to neuronal and glial lineage differentiation, of cultured fetal rat neural stem and progenitor cells expanded using FGF-...
SHEEP ANTI DEHYDROEPIANDROSTERONE...
Biology Products: