Navigation Links
Recent study by Mars, Incorporated and partners underscores importance of metabolism in understanding health benefits of cocoa flavanols
Date:1/25/2012

MCLEAN, VA. (Jan. 25, 2012) --- A comprehensive investigation of flavanol absorption and metabolism has provided a critical step forward in our understanding of how cocoa flavanols work in the body to exert their circulatory and cardiovascular benefits. Through the development of improved analytical methods, this recent work provides detailed insights into the extensive metabolism of flavanols, which calls into question the reliability of in vitro studies using un-metabolized materials. This collaborative research was conducted by an international team of scientists from Mars, Incorporated, the University of California, Davis (US) and the University of Reading (UK).

Increasing scientific evidence indicates that (−)-epicatechin, the main flavanol in cocoa, can have a positive impact on the circulatory and cardiovascular systems. Absorption and metabolism, however, play a key role in determining the exact effect food constituents and nutrients such as (−)-epicatechin have in the body. Following absorption, nutrients are metabolized transforming them into new compounds that are different from those originally present in food. As metabolic transformation has a significant impact on how nutrients support healthy functions, investigating this process is critical to furthering our understanding of exactly how cocoa flavanols are linked to health benefits.

While the metabolism of flavanols has been established in previous studies, the development and validation of improved analytical methods in this research enabled a far more detailed assessment than previously possible. As a result, this study was able to clearly and reliably demonstrate the extensive metabolism of (−)-epicatechin following consumption of a flavanol-containing cocoa drink. As in vitro studies using un-metabolized cocoa flavanols do not take this metabolism into account, they are not able to accurately reflect what is happening in the body. For example, early findings looking at flavanols in a test tube suggested that they exerted their benefits through an antioxidant mechanism. However, this latest research adds to a growing body of evidence challenging this notion and indicating that when examined in the body flavanols' cardiovascular benefits are in fact independent of any antioxidant properties.

Commenting on the impact of this work for future research in the field, Dr. Hagen Schroeter study author and director of fundamental health and nutrition research at Mars, Incorporated stated: "By significantly advancing our understanding of the absorption and metabolism of cocoa flavanols, this research helps to address existing disagreement in this area and sets a new standard in flavanol analytics that will improve the scientific tools available. Furthermore, this work again calls into question the validity of in vitro research that does not take into account the extensive metabolism of compounds like (−)-epicatechin."

"The study provides a critical step towards a more complete understanding of flavanols and their benefits and, ultimately, towards the translation of this knowledge into innovative flavanol-rich food products and concrete health recommendations," added Dr. Schroeter.

The research has been published in the international journal Free Radical Biology and Medicine and is available for free online here: http://www.sciencedirect.com/science/article/pii/S0891584911012548. It forms part of a wider body of collaborative research in this field and builds upon the findings of a previous paper examining flavanol absorption that was published in 2011.


'/>"/>

Contact: Elizabeth Willett
Elizabeth.willett@mss.effem.com
301-768-9100
Mars, Incorporated
Source:Eurekalert

Related biology news :

1. Sea Grant report synthesizes recent research on New Yorks clams
2. Recent news reports of sweetener reformulations raise questions about motivations
3. Autism Speaks responds to recent publications citing autism clusters in California
4. Arctic lake sediments show warming, unique ecological changes in recent decades
5. Ongoing human evolution could explain recent rise in certain disorders
6. Recently analyzed fossil was not human ancestor as claimed, anthropologists say
7. BIO-key(R) International Biometric Accuracy Improved by More Than 23% as Reported in Recent NIST Testing
8. At opening of XVIII International AIDS Conference, scientific, community and political leaders applaud recent progress toward universal access and urge continued momentum to finish what weve started
9. Risk of surgery for Crohns disease lower than reported in recent studies
10. A recent IRCM breakthrough impacts cancer research
11. Recent census in war-torn DR Congo finds gorillas have survived, even increased
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/15/2016)... , April 15, 2016  A new ... make more accurate underwriting decisions in a fraction ... timely, competitively priced and high-value life insurance policies ... screenings. With Force Diagnostics, rapid testing ... lifestyle data readings (blood pressure, weight, pulse, BMI, ...
(Date:4/13/2016)... CHICAGO , April 13, 2016  IMPOWER physicians ... are setting a new clinical standard in telehealth ... By leveraging the higi platform, IMPOWER patients can ... weight, pulse and body mass index, and, when they ... quick and convenient visit to a local retail location ...
(Date:3/29/2016)... 2016 LegacyXChange, Inc. (OTC: ... SelectaDNA/CSI Protect are pleased to announce our successful effort ... variety of writing instruments, ensuring athletes signatures against counterfeiting ... from athletes on LegacyXChange will be assured of ongoing ... Bill Bollander , CEO states, "By ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... 23, 2016  The Biodesign Challenge (BDC), a university ... to harness living systems and biotechnology, announced its winning ... New York City . ... showcased projects at MoMA,s Celeste Bartos Theater during the ... MoMA,s senior curator of architecture and design, and ...
(Date:6/23/2016)... ... June 23, 2016 , ... Supplyframe, the Industry Network for ... Design Lab . Located in Pasadena, Calif., the Design Lab’s mission is to ... are designed, built and brought to market. , The Design Lab is Supplyframe’s ...
(Date:6/23/2016)... ... June 23, 2016 , ... In a new case report published today ... a patient who developed lymphedema after being treated for breast cancer benefitted from an ... paradigm for dealing with this debilitating, frequent side effect of cancer treatment. ...
(Date:6/23/2016)... June 23, 2016  Blueprint Bio, a company dedicated ... the medical community, has closed its Series A funding ... . "We have received a commitment from ... we need to meet our current goals," stated ... the runway to complete validation on the current projects ...
Breaking Biology Technology: