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Recent highlights in Molecular Biology and Evolution
Date:9/17/2013

nment is a topic of increasing interest in biology and medicine. The different strain variances we see suggest that the extent of nongenetic heterogeneity is itself genetically determined."

Further investigations could pave the way to a more complete understanding of the genetics and metabolomics of cell growth in yeast and the underlying mechanisms relevant to other settings in which cells face challenging conditions, such as cancer progression and the evolution of drug resistance.

To access the full online article: http://mbe.oxfordjournals.org/content/early/2013/08/11/molbev.mst138.abstract

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David Gresham
Center for Genomics and Systems Biology
Department of Biology
New York University,
New York, USA
dgresham@nyu.edu

Mark L. Siegal
Center for Genomics and Systems Biology
Department of Biology
New York University,
New York, USA
mark.siegal@nyu.edu


Examining the source behind Sherpa mountain fitness

The Sherpa population in Tibet is world-renowned for their extraordinary high-altitude fitness, as most famously demonstrated by Tenzing Norgay's ability to conquer Mount Everest alongside Sir Edmund Hillary. The genetic adaptation behind this fitness has been a topic of hot debate in human evolution, with recent full genome sequencing efforts completed to look for candidate genes necessary for low oxygen adaptation. However, few have looked at the Sherpa population by sequencing their mitochondrial genomes---the powerhouse of every cell that helps determine the degree of respiratory fitness by providing 90 percent of the human body's energy demand, as well as controlling the metabolic rate and use of oxygen.

Unlike genomic DNA,
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Contact: Joe Caspermeyer
MBEpress@gmail.com
480-258-8972
Molecular Biology and Evolution (Oxford University Press)
Source:Eurekalert

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