Navigation Links
Recent highlights in Molecular Biology and Evolution
Date:9/17/2013

Diversity of microbial growth strategies in a limited nutrient world

The budding yeast, Saccharomyces cerevisiae, is a prime organism for studying fundamental cellular processes, with the functions of many proteins important in the cell cycle and signaling networks found in human biology having first been discovered in yeast.

Now, scientists from New York University have now developed a sophisticated assay to track cell growth at very low nutrient concentrations. The assay uses time-lapse microscopy to monitor individual yeast cells undergoing a small number of divisions to form microcolonies. The assay can measure the lag times and growth rates of as many as 80,000 individual microcolonies in a single 24-hour experiment, opening up a powerful new high-throughput tool to study the complex interplay between cell growth, division and metabolism under environmental conditions that are likely to be ecologically relevant but had previously been difficult to study in the laboratory.

The researchers studied growth rates and lag times in both lab strains and wild yeast by varying the amount of its prime carbon food source, glucose. They confirmed the prediction made over 60 years ago by Noble-prize-winning biologist Jacques Monod regarding changes in microbial growth rates with limited nutrients (the Monod equation). They also found significant differences among strains in both the average lag response (the amount of time it takes to transition from cell quiescence to restarting cell growth) and average growth rates in response to different environmental conditions.

In addition to average differences between strains and conditions, the powerful assay revealed metabolic differences among cells of the same strain in the same environment. Moreover, yeast strains differed in their variances in growth rate. According to the study's lead author, Naomi Ziv, "Heterogeneity among genetically identical cells in the same enviro
'/>"/>

Contact: Joe Caspermeyer
MBEpress@gmail.com
480-258-8972
Molecular Biology and Evolution (Oxford University Press)
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Highest winter losses in recent years for honey bees in Scotland
2. Recent progress in gene-sensing strategies for rapid detection of foodborne pathogens
3. The equine Adam lived fairly recently: Close relationships among modern stallions
4. Volcanic aerosols, not pollutants, tamped down recent Earth warming, says CU-Boulder study
5. Recent breakthroughs in cocoa flavanol research discussed by European research consortium and expert panel
6. Recent study suggests bats are reservoir for ebola virus in Bangladesh
7. Invading species can extinguish native plants despite recent reports
8. Recent studies bring fossils and genes together to piece together evolutionary history
9. GEN reports on recent progress in Alzheimers research
10. From 503-million-year-old fungi to recent earthquakes: New Geology posted ahead of print
11. Research highlights from ICAAC meeting
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/17/2014)... new way the immune system may fight cancers and ... immune cells to treat illness. , The research, in ... of "neighborhood police" specialized squads of defenders that ... an entire city, the body. , Scientists at Washington ... that the liver, skin and uterus each has dedicated ...
(Date:4/17/2014)... View of Domestication," a special feature of The ... ( PNAS ) published April 29, raises a ... deep history that most of us take for granted. ... in many spots around the globe shifted from hunting ... and plants. , It seems so straightforward and yet ...
(Date:4/16/2014)... green sea turtle fishery has uncovered a stark reality: ... may have become an unsustainable take, according to conservation ... Florida. , During the research period, conservation scientists estimated ... 1991 and 2011, with catch rates peaking in 1997 ...
Breaking Biology News(10 mins):Some immune cells defend only 1 organ 2Genetic study tackles mystery of slow plant domestications 2Genetic study tackles mystery of slow plant domestications 3Genetic study tackles mystery of slow plant domestications 4Declining catch rates in Caribbean green turtle fishery may be result of overfishing 2Declining catch rates in Caribbean green turtle fishery may be result of overfishing 3
... effect on the formation of cells in the intervertebral discs. ... University of Gothenburg, presented at the annual meeting of the ... which is currently taking place in Gothenburg. The ... a positive effect on cells in the intervertebral discs. The ...
... (CVD), driven by the global pandemics of obesity and ... 21st century. Despite progress, there is still much to ... key risk factor. In Europe, as many as one-half ... specifically focused on managing dyslipidaemias offer new hope.3,4 Experts ...
... shallow water sandy bottoms on the surface appear desert-like and ... a diverse fauna flourishes. In addition to bacteria and protozoa ... One of the strangest members of this interstitial fauna is ... flatworm, which is found from tropical oceans to the Mediterranean. ...
Cached Biology News:Exercise produces positive effects on the intervertebral discs 2First joint ESC/EAS guidelines for the management of dyslipidaemias 2First joint ESC/EAS guidelines for the management of dyslipidaemias 3First joint ESC/EAS guidelines for the management of dyslipidaemias 4Ancient symbiosis between animals and bacteria discovered 2
(Date:1/15/2014)... "The interface is the device," Nobel laureate Herbert ... to be found at the junctures where layers ... of nanotechnology, the interfaces between layers of metal ... such high-tech favorites as spintronics, high-temperature superconductors, ferroelectrics ...
(Date:1/15/2014)... Calif. (PRWEB) January 15, 2014 Cynvenio, ... and management through the genomic analysis of tumor cells ... Therapy Finder™, a web-based cancer decision support application powered ... option with Cynvenio’s ClearID™ genomic test, Therapy Finder will ...
(Date:1/15/2014)... More than 5 million Americans are currently ... seniors will die with Alzheimer’s or another dementia, according ... shocked many Americans into looking for ways to improve ... age-related cognitive disorders. Jonathan Weisman, president of Biohack Pure, ...
(Date:1/15/2014)... Freeslate, Inc ., the leading provider of ... one of India’s top five pharmaceutical companies, has received ... for high throughput solid form screening. , Lupin, ... range of quality, affordable generic and branded formulations and ...
Breaking Biology Technology:A deeper look at interfaces 2Cynvenio Offers New Breast Cancer Therapy Finder Application for its ClearID Breast Cancer Genomic Test 2Cynvenio Offers New Breast Cancer Therapy Finder Application for its ClearID Breast Cancer Genomic Test 3Biohack Pure Offers 5 Tips for Increasing Memory in 2014 2Lupin Selects Freeslate’s CM Protégé PharmD System to Accelerate Polymorph Screening for Drug Development 2Lupin Selects Freeslate’s CM Protégé PharmD System to Accelerate Polymorph Screening for Drug Development 3
... Century Health announced today that its board of directors ... Dr. Dhir will spearhead the national expansion of New ... and cardiology.  Water Street Healthcare Partners, a strategic private ... in New Century Health last year, recruited Dr. Dhir ...
... Life Technologies Corporation (NASDAQ: LIFE ) ... intention to redeem all of the outstanding 1.5% Convertible ... February 15, 2012. As of December 31, 2011 there ... Convertible Notes outstanding. The redemption notice provided includes CUSIP ...
... nano-composites are used in a wide variety of ... automotive and aerospace applications. Thermal analysis is routinely ... the growing trend to use nanostructured materials has ... years an atomic force microscope-based technique called nanoscale ...
Cached Biology Technology:Former Sanofi-aventis and US Oncology Executive Joins New Century Health as Chief Executive Officer 2Life Technologies Announces Redemption of 1.5% Convertible Senior Notes Due 2024 2Magnetic actuation enables nanoscale thermal analysis 2
A flexible 24-48 hour DNA sequencing service. Samples may be shipped in standard 1.5mL tubes. Oligo synthesis and DNA preparation available. Read lengths up to 850 Phred 20 bases. Universal primers p...
... pass sequencing of plasmids and PCR ... our high performance sequencing pipeline which ... per day. The key benefits we ... are rapid turnaround, high sequencing pass ...
... Fully automated, GLP-compliant Facility , Galaxy ... software , Highly experienced scientists ,We offer ... inserts or full plasmids for single or ... is used when the DNA of interest ...
... of individual research samples, including PCR amplicons, ... world-class, high performance sequencing pipeline processes over ... The key benefits of Agencourt's QuickLane Research ... hour sample turnaround, industry leading sequence quality ...
Biology Products: