Navigation Links
Recapitulation of the entire hepatitis C virus life in engineered mouse cell lines
Date:4/19/2012

A US study presented today at The International Liver CongressTM 2012 demonstrates that the entire HCV lifecycle can be recapitulated in murine cells, implying that HCV permissive mouse models could soon be developed.(1)

The data suggests that HCV replication in the murine environment is limited by innate immune responses. Inactivating these pathways and the expression of the appropriate entry factors and miR-122 creates murine fibroblasts that can be infected and support replication.

The study also corroborates previous data that the expression of apoE promotes production of infectious virus.

Although mouse orthologs of MAVS and TRIF could be cleaved by the HCV NS3/4A protease, this was not enough to establish robust HCV replication.

In contrast, impairment of type I and type III IFN signaling enhanced the permissiveness of murine fibroblasts for persistent HCV replication.

The in-depth study of hepatitis C pathogenesis and immune responses is currently hampered by the lack of suitable small animal models. This study is a positive step to addressing this issue.


'/>"/>

Contact: Travis Taylor
easlpressoffice@cohnwolfe.com
44-789-438-6428
European Association for the Study of the Liver
Source:Eurekalert

Page: 1

Related biology news :

1. Electrical circuit runs entirely off power in trees
2. New York autopsies show 2009 H1N1 influenza virus damages entire airway
3. Researchers use entire islands in the Bahamas to test survival of the fittest
4. Entire issue of scientific journal devoted to center headed by Scripps Research Scientists
5. New technology provides first view of DNA damage within entire human genome
6. Researchers find local wildlife protection safeguards entire range
7. New data published in Nature Genetics demonstrate that tiny LNA-based compounds developed by Santaris Pharma A/S inhibit entire disease-associated microRNA families
8. Unknown ocean bacteria create entirely new theories
9. Entire genome of extinct human decoded from fossil
10. Leeds research points to new therapy for hepatitis C treatment
11. Discovery could lead to a new animal model for hepatitis C
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/22/2017)... , March 21, 2017 Optimove ... used by retailers such as 1-800-Flowers and AdoreMe, ... — Product Recommendations and Replenishment. Using Optimove,s machine learning ... personalized product and replenishment recommendations to their customers ... on predictions of customer intent drawn from a ...
(Date:3/13/2017)... Future of security: Biometric Face Matching software  Continue ... ... to match face pictures against each other or against large databases. The recognition ... ... software for biometric Face Matching on the market. The speed is at 100 ...
(Date:3/6/2017)... MATEO, Calif. , March 6, 2017 /PRNewswire/ ... marketing and sales technology, today announced Predictive Sales ... solution for infusing actionable sales intelligence into Salesforce. ... to automatically enable their sales organizations with deep ... messages that allow for intelligent engagement. Predictive Sales ...
Breaking Biology News(10 mins):
(Date:3/30/2017)... In today,s pre-market research, Stock-Callers.com ... Corp. (NYSE: XON), Progenics Pharmaceuticals Inc. (NASDAQ: PGNX), and ... an article on Barron,s, Credit Suisse upgraded its rating on ... 21 st , 2017. These stocks research reports can be ... ...
(Date:3/29/2017)... Texas, March 29, 2017  Vermillion, Inc. (NASDAQ: ... disease, reported on its results for the fourth ... "2016 marked a pivotal year for ... guideline inclusion, international distribution agreements, major reimbursement progress ... network payer agreements. In addition we cleared our ...
(Date:3/29/2017)... N.J. and PETACH TIKVAH, ...  BrainStorm Cell Therapeutics Inc. (NASDAQ: BCLI), ... technologies for neurodegenerative diseases, announced financial results ... "2016 was a highly successful ... important achievements and significant progress made on ...
(Date:3/29/2017)... ... March 29, 2017 , ... On the heels of the globally recognized ... Travel has announced that it will manage travel services for its 500th clinical trial ... the United States and Europe to offer travel management services specifically for clinical trials ...
Breaking Biology Technology: