Navigation Links
Reading the human genome
Date:2/27/2013

p-by-step cryo-EM images was how the transcription factor protein TFIIF engages Pol II and promoter DNA to stabilize both a closed DNA pre-initiation complex and an open DNA-promoter complex, and also how it regulates the selection of a transcription start-site.

"Comparing the closed versus open DNA states led us to propose a model that describes how DNA is moved during the process of promoter opening," says He. "Our studies provide insight into how THIIH uses ATP hydrolysis as a source of energy to actually open and push the DNA to the active site of Pol II."

Nogales and her colleagues plan to further investigate the process of DNA loading into Pol II, as well as to include additional transcription factors into the assembly that are required for regulation of gene expression.

"Our goal is to actually build a structural model of the entire - more than two million daltons - protein machinery that recognizes and regulates all human DNA promoters," Nogales says. "For now we have the structural framework that's been needed to integrate biochemical and structural data into a unified mechanistic understanding of transcription initiation."


'/>"/>

Contact: Lynn Yarris
lcyarris@lbl.gov
510-486-5375
DOE/Lawrence Berkeley National Laboratory
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. MindSpec launches online Autism Reading Room
2. New model of disease contagion ranks US airports in terms of their spreading influence
3. Flightless molecule may prevent cancer from spreading from 1 tissue to another
4. Frequent traveller: Dysentery-causing bacteria spreading from Europe to Australia
5. Brain-wave-reading robot might help stroke patients
6. New book on stereology by Mark West is essential reading for neurobiologists
7. Joint UT study: Reading food labels helps shoppers stay thinner
8. Reading history through genetics
9. Stanford researchers develop tool for reading the minds of mice
10. Nearby chimpanzee populations show much greater genetic diversity than distant human populations
11. UC Santa Barbara researchers discover genetic link between visual pathways of hydras and humans
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Reading the human genome
(Date:10/16/2014)... , October 16, 2014 NXT-ID, Inc. ... the "Company"), a biometric authentication company focused on the ... leading edge technologies including Wocket™, the Smart Wallet, at ... Conferenece. FiRe is a leading global conference on the ... Hosted by Mark Anderson , founder and publisher ...
(Date:10/15/2014)... pandemic risk from strains of influenza virus increases with ... to become complacent that the most substantial threats have ... Influenza pandemics arise when a new virus strain – ... – spreads in the human population. There have been ... worst of which – the 1918 Spanish Flu – ...
(Date:10/15/2014)... admitted Johannes Gutenberg University Mainz (JGU) as a ... continues to maintain a significant nationwide standing in ... acceptance of Johannes Gutenberg University Mainz as a ... in the national and international competition for the ... Rhineland-Palatinate can be proud that Mainz University has ...
Breaking Biology News(10 mins):NXT-ID Inc. to Present at 13th Annual FiRe Conference 2NXT-ID Inc. to Present at 13th Annual FiRe Conference 3Scientists 'must not become complacent' when assessing pandemic threat from flu viruses 2Johannes Gutenberg University Mainz joins Germany's Gauss-Allianz as a full member 2Johannes Gutenberg University Mainz joins Germany's Gauss-Allianz as a full member 3
... rare frog (Amolops tormotus) in China sings like a ... sounds. Now scientists say that these concave-eared torrent frogs ... findings, to appear in the March 16 issue of ... being able to communicate like bats, whales and dolphins, ...
... at Austin have developed a quick and simple way to ... role in infection and immunity. , The sugars coating bacteria ... cloaking the bacteria from the immune system of their host. ... catch these rapid changes. , "There's a growing ...
... the Forsyth Institute have discovered a new mechanism responsible ... locate themselves on the left or right side of ... mechanism, garnered through the study of three different vertebrates ... a single common mechanism has been identified in left-right ...
Cached Biology News:Rare Chinese frogs communicate by means of ultrasonic sound 2Rare Chinese frogs communicate by means of ultrasonic sound 3Scientists seek to unwrap the sweet mystery of the sugar coat on bacteria 2Forsyth scientists gain greater understanding of how embryos differentiate left from right 2Forsyth scientists gain greater understanding of how embryos differentiate left from right 3
(Date:10/19/2014)... Orthopedic braces and support systems report defines and segments the ... The Orthopedic braces and support systems market in Asia is ... a developing CAGR of 4.4% from 2013 to 2018. , ... support systems market, to get an idea of the in-depth ... of orthopedic braces and support systems market in the same ...
(Date:10/18/2014)... The Asia-Pacific Bio-based Advanced Phase Change ... advanced phase change material market in Asia-Pacific with ... the TOC of the Asia-Pacific Bio-based Advanced Phase ... of the in-depth analysis provided. This also provides ... bio-based advanced phase change material market, and is ...
(Date:10/18/2014)... Asia-Pacific Liquid Crystal on Silicon (LCoS) display market report ... analysis and forecast of revenue. This market was valued ... reach $380.0 million by 2018, at a CAGR of ... TOC of the Asia-Pacific LCoS display market report, to ... also provides a glimpse of the segmentation of the ...
(Date:10/18/2014)... (PRWEB) October 18, 2014 The ... Business Intelligence] - Text; Web; Speech; Machine; Video; ... Enterprise Roadmap, Market Forecasts & Analysis (2013 - ... Analytics Market into various sub segments with an ... report also identifies the factors driving this market, ...
Breaking Biology Technology:The Asian Orthopedic braces and support systems market is estimated to grow to around $416.5 million by 2018 - New Report by MicroMarket Monitor 2The Asian Orthopedic braces and support systems market is estimated to grow to around $416.5 million by 2018 - New Report by MicroMarket Monitor 3The Asian Orthopedic braces and support systems market is estimated to grow to around $416.5 million by 2018 - New Report by MicroMarket Monitor 4The Asia-Pacific Bio-based Advanced Phase Change Materials Market is estimated to grow to $39.8 million by 2018 - New Report by MicroMarket Monitor 2The Asia-Pacific Bio-based Advanced Phase Change Materials Market is estimated to grow to $39.8 million by 2018 - New Report by MicroMarket Monitor 3The Asia-Pacific Bio-based Advanced Phase Change Materials Market is estimated to grow to $39.8 million by 2018 - New Report by MicroMarket Monitor 4The Asia-Pacific Liquid Crystal on Silicon (LCoS) display market is expected to reach $380.0 million by 2018 - New Report by MicroMarket Monitor 2The Asia-Pacific Liquid Crystal on Silicon (LCoS) display market is expected to reach $380.0 million by 2018 - New Report by MicroMarket Monitor 3Cloud Analytics Market (by Cloud Business Intelligence & Predictive Analytics) Expected to Cross $16.52 Billion by 2018 - New Report by MarketsandMarkets 2Cloud Analytics Market (by Cloud Business Intelligence & Predictive Analytics) Expected to Cross $16.52 Billion by 2018 - New Report by MarketsandMarkets 3Cloud Analytics Market (by Cloud Business Intelligence & Predictive Analytics) Expected to Cross $16.52 Billion by 2018 - New Report by MarketsandMarkets 4Cloud Analytics Market (by Cloud Business Intelligence & Predictive Analytics) Expected to Cross $16.52 Billion by 2018 - New Report by MarketsandMarkets 5
... , CAMBRIDGE, Mass., July 14 Idenix Pharmaceuticals, ... report its financial results for the second quarter of 2009 on ... , In conjunction with the issuance of ... 4:30 p.m. ET on Monday, July 20, 2009 to discuss the ...
... , , , LAKE ... technology company focused on improving blood collection, separation, safety and ... agreement with Verax Biomedical Incorporated to market, sell and distribute ... used to detect bacterial contaminants in donated blood platelets. ...
... , VIENNA, Austria, July 14 Elan ... WYE ) presented information this week at the Alzheimer Association ... and one podium presentation about the growing burden of care and ... This information sheds light on the impact of AD, which, ...
Cached Biology Technology:Improving Transfusion Safety: Fenwal, Verax Biomedical Sign Agreement for Rapid, Point-of-Care Bacteria Test 2Improving Transfusion Safety: Fenwal, Verax Biomedical Sign Agreement for Rapid, Point-of-Care Bacteria Test 3Studies Presented at International Conference on Alzheimer's Disease Reveal Substantial Economic Costs and Caregiver Burden Associated with Alzheimer's Disease 2Studies Presented at International Conference on Alzheimer's Disease Reveal Substantial Economic Costs and Caregiver Burden Associated with Alzheimer's Disease 3Studies Presented at International Conference on Alzheimer's Disease Reveal Substantial Economic Costs and Caregiver Burden Associated with Alzheimer's Disease 4Studies Presented at International Conference on Alzheimer's Disease Reveal Substantial Economic Costs and Caregiver Burden Associated with Alzheimer's Disease 5Studies Presented at International Conference on Alzheimer's Disease Reveal Substantial Economic Costs and Caregiver Burden Associated with Alzheimer's Disease 6Studies Presented at International Conference on Alzheimer's Disease Reveal Substantial Economic Costs and Caregiver Burden Associated with Alzheimer's Disease 7
... consists of FAST RED chromogen,tablets and substrate ... of alkaline phosphatase to produce red staining ... RED System provides enough material for 300 ... Vial A: 6 Tablets , Vial B: ...
The BioLogic Maximizer mixer is for use with the Maximizer valve system. The mixer improves gradient quality by mixing the output of the BioLogic DuoFlow workstation pumps....
... effectively in tubes and 96 well plates. microCLEAN ... one and a half spin DNA cleanup reagent. ... concentrate any type of double stranded DNA, efficiently ... dNTPs (labelled or unlabelled). It is therefore ideally ...
... cycler holds 96 x 0.2 ml tubes ... lid incorporates a thumbwheel to adjust height ... for oil-free cycling. Peltier heat pumps produce ... ramping rates of up to 1.4 degrees ...
Biology Products: