Navigation Links
Reading the human genome
Date:2/27/2013

p-by-step cryo-EM images was how the transcription factor protein TFIIF engages Pol II and promoter DNA to stabilize both a closed DNA pre-initiation complex and an open DNA-promoter complex, and also how it regulates the selection of a transcription start-site.

"Comparing the closed versus open DNA states led us to propose a model that describes how DNA is moved during the process of promoter opening," says He. "Our studies provide insight into how THIIH uses ATP hydrolysis as a source of energy to actually open and push the DNA to the active site of Pol II."

Nogales and her colleagues plan to further investigate the process of DNA loading into Pol II, as well as to include additional transcription factors into the assembly that are required for regulation of gene expression.

"Our goal is to actually build a structural model of the entire - more than two million daltons - protein machinery that recognizes and regulates all human DNA promoters," Nogales says. "For now we have the structural framework that's been needed to integrate biochemical and structural data into a unified mechanistic understanding of transcription initiation."


'/>"/>

Contact: Lynn Yarris
lcyarris@lbl.gov
510-486-5375
DOE/Lawrence Berkeley National Laboratory
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. MindSpec launches online Autism Reading Room
2. New model of disease contagion ranks US airports in terms of their spreading influence
3. Flightless molecule may prevent cancer from spreading from 1 tissue to another
4. Frequent traveller: Dysentery-causing bacteria spreading from Europe to Australia
5. Brain-wave-reading robot might help stroke patients
6. New book on stereology by Mark West is essential reading for neurobiologists
7. Joint UT study: Reading food labels helps shoppers stay thinner
8. Reading history through genetics
9. Stanford researchers develop tool for reading the minds of mice
10. Nearby chimpanzee populations show much greater genetic diversity than distant human populations
11. UC Santa Barbara researchers discover genetic link between visual pathways of hydras and humans
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Reading the human genome
(Date:7/30/2014)... Scientists are searching through a massive collection of ... 50 years ago, and the effort is yielding fresh ... inhabited. , When the collection is fully curated, a ... the largest unbiased Dominican amber collection in the world, ... discovery thus far is that of a pygmy locust, ...
(Date:7/30/2014)... Wayne State University,s College of Engineering recently received ... for the project, "Nanoparticle-directed synthesis of organic nanorods." ... nanotechnology is the creation and utilization of functional ... functions. A major bottleneck in scaling up nanotechnology ... different functional materials into one device. A research ...
(Date:7/30/2014)... major interest in neuroscience. A large number of ... of Wallerian degeneration: transcription factor activation, immune response, ... responses in the distal segment of the sciatic ... in gene expression between the proximal and distal ... from Nantong University, China used microarrays to analyze ...
Breaking Biology News(10 mins):Decades-old amber collection offers new views of a lost world 2NSF grant to Wayne State supports new concept for manufacturing nanoscale devices 2
... 10, 2010) -- Just as the path of photons of ... magnetic moment can be controlled using a magnetic mirror. Research ... the feasibility of using magnetic domain walls to direct and ... "We are looking for ways to build magnetic ...
... , This release is available in Spanish ... were found to have low serum (blood) zinc concentrations during ... and the National Institute of Aging. The scientists ... 50 percent less likely to develop pneumonia than those with ...
... - A new technology enabling tiny machines called ... super-accurate and precise sensors for crime-scene forensics, environmental ... enable researchers to create a "nose-on-a-chip" for tracking ... gaseous substances, as well as a new class ...
Cached Biology News:Adequate zinc eases pneumonia in elderly 2Innovation could bring super-accurate sensors, crime forensics 2Innovation could bring super-accurate sensors, crime forensics 3Innovation could bring super-accurate sensors, crime forensics 4
(Date:7/30/2014)... While administrative claims and other data ... a relatively long period of time, there has ... of these ‘big data’ for comparisons of interventions ... powerful computer technology with the plethora of data ... significant promise for identifying optimal interventions for specific ...
(Date:7/30/2014)... July 30, 2014   Wyle has ... Integrated Lifecycle Mission Support Services (FILMSS) contract awarded ... Under the terms of the contract, Wyle will ... Moffett Field, Calif. In particular, Wyle will provide ... development projects on the International Space Station and ...
(Date:7/30/2014)... BCC Research ( http://www.bccresearch.com ) reveals ... in Industrial Applications , the global market for industrial ... by 2018, registering a five-year compound annual growth rate ... recorded in the detergent enzyme segment with a CAGR ... has influenced almost every sector of industrial activity, ranging ...
(Date:7/30/2014)... SAN DIEGO , July 30, 2014  Orexigen ... it has received the Day 180 List of Outstanding ... Medicinal Products for Human Use (CHMP) for the NB32 ... / bupropion SR) is an investigational drug candidate being ... of the earlier Day 120 time point were adequately ...
Breaking Biology Technology:Leveraging ‘Big Data’ - Methodological Considerations in Health Services Research, New Webinar Hosted by Xtalks 2Wyle Wins NASA's Fully Integrated Lifecycle Mission Support Services Contract 2Global Market for Industrial Enzymes to Reach Nearly $7.1 Billion by 2018; Detergent Enzyme Market to Record Maximum Growth 2Global Market for Industrial Enzymes to Reach Nearly $7.1 Billion by 2018; Detergent Enzyme Market to Record Maximum Growth 3Orexigen Receives CHMP Day 180 List of Outstanding Issues 2Orexigen Receives CHMP Day 180 List of Outstanding Issues 3
... 11 Lucid, Inc., (http://www.lucid-tech.com ), a leading ... Colin Stahel as Director, Asia Pacific Region., ... the newly created,position based on his extensive medical ... experience in the development of medical,technology and pre-cancer ...
... Belgium, December 11 , - TB-402 Shows ... Prevention of Thromboembolic Disorders., ThromboGenics NV (Euronext ... disease, announced that the results of the,first Phase ... the prestigious,American Society of Hematology (ASH) 49th Annual ...
... Mass., Dec. 10 Cambridge Research &,Instrumentation, Inc. ... breakthrough system that converts any brightfield or,fluorescent microscope ... of a larger specimens, such as embryos,zebrafish, plants, ... can,be mounted onto a fluorescent macroscope. The Nuance ...
Cached Biology Technology:Lucid Expands Support Internationally: Dr. Colin Stahel appointed Director for Asia Pacific Region 2ThromboGenics Presents Results of the Phase I Trial of TB-402 at the Prestigious American Society of Hematology Annual Meeting 2ThromboGenics Presents Results of the Phase I Trial of TB-402 at the Prestigious American Society of Hematology Annual Meeting 3ThromboGenics Presents Results of the Phase I Trial of TB-402 at the Prestigious American Society of Hematology Annual Meeting 4CRi Announces Nuance 2, the Next-Generation Multispectral Imaging System for Brightfield and Fluorescent-Based Microscopy 2
...
Recalibration of HL-2000-CAL products...
Mature rat whole blood (Sprague-Dawley, averaging 7-8 weeks of age, either sex) is collected at the time of slaughter and processed within 45 minutes. It is then filtered through gauze, pooled in an ...
Several Pichia pastoris strains are available to allow you to optimize expression and recovery of your protein of interest. Table 1 provides information to help you choose the appropriate strain....
Biology Products: