Navigation Links
Reactivation of the AKT survival pathway by ERK1/2
Date:1/7/2014

In the study by Toulany et al., it was demonstrated for the first time that long term treatment with inhibitors of PI3K (as it is performed clinically) results in a reactivation of the major survival component Akt through a so far unknown regulatory loop via ERK1/2. This reactivation of Akt limits quite efficiently the response of the tested tumor cell lines presenting constitutively active K-Ras activity (both through K-RAS mutation or over-expression of K-RAS wildtype) to antagonistic strategies directed against PI3K. Thus, the described ERK1/2 dependency of reactivation of Akt gives new insights into the underlying mechanisms of resistance accompanying EGFR and PI3K antagonizing strategies. Moreover and clinically perhaps even more importantly, these findings provide specific hints how the combination of MEK-ERK1/2 and PI3K inhibitors can efficiently be used to overcome therapy resistance of tumors presenting constitutively high K-Ras activity.


'/>"/>

Contact: Andrew Thompson
andrew@landesbioscience.com
Landes Bioscience
Source:Eurekalert

Page: 1

Related biology news :

1. Study: Viral reactivation a likely link between stress and heart disease
2. Imaging technology to improve survival of ischemic disease patients
3. Mannotriose promotes survival of hippocampal neurons
4. Researchers create largest evolutionary timetree of land plants to investigate traits that permit survival in cold climates
5. Blocking tumor-associated macrophages decreased glioblastomas growth & extended survival in mice
6. UCSB biomedical scientist discovers a new method to increase survival in sepsis
7. Study examines potential evolutionary role of sexual regret in human survival and reproduction
8. SIGNAL found to enhance survival of new brain cells
9. Sex over survival: Reproductive trait in fish impedes tissue regeneration
10. Biological therapy with cediranib improves survival in women with recurrent ovarian cancer
11. Research shows how aspirin may act on blood platelets to improve survival in colon cancer patients
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/23/2015)... -- Research and Markets ( http://www.researchandmarkets.com/research/rzzp3v/global_outlook_of ) has ... of the Biometrics Industry 2015 " report ... biometrics market is likely to witness significant growth ... the uptake of multiple technologies available. The year ... growth of biometrics in existing applications as well ...
(Date:7/21/2015)... 2015 Passwords have proven futile for ... recent U.S. Office of Personnel Management breach. Biometric ... conundrum, but developers and end-users are concerned about ... dilemma, Biometrics-as-a-Service provider HYPR Corp. announced today the ... third party integration. A video ...
(Date:7/13/2015)... , Jul. 13, 2015 NXT-ID, Inc. (NASDAQ: ... biometric authentication company focused on the growing mobile ... provisional patent 62/188684 for BEHAVIORAL-DIRECTED AUTHENTIATION ... new convenient and secure method to make payments.  ... payment methods, introduced with its groundbreaking voice-direct payment ...
Breaking Biology News(10 mins):Global Outlook of the Biometrics Industry 2015 2Global Outlook of the Biometrics Industry 2015 3HYPR Corp. Launches Industry First Biometric Tokenization Platform 2HYPR Corp. Launches Industry First Biometric Tokenization Platform 3HYPR Corp. Launches Industry First Biometric Tokenization Platform 4NXT-ID Patents Behavior-Directed Payments 2NXT-ID Patents Behavior-Directed Payments 3NXT-ID Patents Behavior-Directed Payments 4
... just been seen by synchronizing brain waves in a working ... of Health suggests. The more in-sync such electrical signals of ... more those cells held the short-term memory of a just-seen ... a grantee of NIH,s National Institute of Mental Health (NIMH), ...
... USA In the evolutionary long run, small critters tend ... the idea attributed to paleontologist Edward Cope, now known as ... new test of this rule as it applies dinosaurs shows ... long time, dinosaurs were thought to be the example of ...
... in Norway have found new support for their theory ... non-psychotic individuals, leading to long-term psychosis. In an fMRI ... , researchers found a different brain activity pattern in ... patients without prior cannabis use. The results ...
Cached Biology News:In-sync brain waves hold memory of objects just seen 2Were dinosaurs destined to be big? Testing Cope's rule 2Cannabis use mimics cognitive weakness that can lead to schizophrenia 2
(Date:7/28/2015)... 28, 2015  PDL BioPharma, Inc. (PDL, or the ... Company will release its second quarter 2015 financial results ... August 5, 2015, after market close. PDL,s management will ... 4:30 p.m. Eastern Time to discuss the financial results. ... available via the webcast link on the PDL website. ...
(Date:7/28/2015)... , ... July 28, 2015 , ... ... than EUR 1.022 billion in 2013; while production volume reached close to 1.84 ... producing country with a share of 75.5% of the region’s total aluminium hydroxide ...
(Date:7/28/2015)... ... July 28, 2015 , ... VetStem Biopharma will be offering weekly private guided ... local area veterinarians. , The tour and course will be given every Wednesday at ... VetStem’s Poway facility. Staff members are welcome to attend with their veterinarian as well. ...
(Date:7/28/2015)... July 28, 2015  Kerastem Technologies announce that the ... U.S. FDA Center For Biologics Evaluation and Research (CBER) ... a clinical trial investigating the safety and feasibility of ... early male pattern baldness (androgenic alopecia). The ... initial clinical work in Europe ...
Breaking Biology Technology:PDL BioPharma to Announce Second Quarter 2015 Financial Results on August 5, 2015 2EU27 Aluminium Hydroxide Market Analysed and Forecast by BAC Reports in New Research Study Available at MarketPublishers.com 2EU27 Aluminium Hydroxide Market Analysed and Forecast by BAC Reports in New Research Study Available at MarketPublishers.com 3VetStem Biopharma weekly veterinary continuing education classes and GMP manufacturing facility tour 2Kerastem Receives Conditional Approval from FDA for Alopecia Trial 2
... Technology Council , a policy advisor to the governor ... eight additions to its board of directors. , ,The ... board that includes more than three dozen members of ... organization leaders: , , Eric Apfelbach, president and CEO ...
... Sciences today announced the release of a product that ... proteins, and perhaps improve the cost effectiveness of drug discovery. ... an extension of the company's existing PreserveX line, and it ... Society of Japan in Kyoto, Japan. CEO Ralph Kauten said ...
... move forward on its deployment of Project Lightspeed? , ,If ... be setting its sights higher on real broadband and long-term ... marketing strategy of Project Lightspeed should be to get fiber ... a true broadband package. Instead, it is a way to ...
Cached Biology Technology:AT&T should set sights higher than repackaging DSL with Project Lightspeed 2AT&T should set sights higher than repackaging DSL with Project Lightspeed 3AT&T should set sights higher than repackaging DSL with Project Lightspeed 4AT&T should set sights higher than repackaging DSL with Project Lightspeed 5AT&T should set sights higher than repackaging DSL with Project Lightspeed 6
A robust formulation of Taq Polymerase supplied with a 10X colored reaction buffer which allows Direct Gel-Loading...
A formulation of our Biolase DNA Polymerase which contains a Red Loading Dye...
Homo sapiens similar to Cytosolic acyl coenzyme A thioester hydrolase Antigen: Peptide...
Cag-A (IgG) -Ab EIA Sample Size: 10 l...
Biology Products: