Navigation Links
Reactivation of the AKT survival pathway by ERK1/2
Date:1/7/2014

In the study by Toulany et al., it was demonstrated for the first time that long term treatment with inhibitors of PI3K (as it is performed clinically) results in a reactivation of the major survival component Akt through a so far unknown regulatory loop via ERK1/2. This reactivation of Akt limits quite efficiently the response of the tested tumor cell lines presenting constitutively active K-Ras activity (both through K-RAS mutation or over-expression of K-RAS wildtype) to antagonistic strategies directed against PI3K. Thus, the described ERK1/2 dependency of reactivation of Akt gives new insights into the underlying mechanisms of resistance accompanying EGFR and PI3K antagonizing strategies. Moreover and clinically perhaps even more importantly, these findings provide specific hints how the combination of MEK-ERK1/2 and PI3K inhibitors can efficiently be used to overcome therapy resistance of tumors presenting constitutively high K-Ras activity.


'/>"/>

Contact: Andrew Thompson
andrew@landesbioscience.com
Landes Bioscience
Source:Eurekalert

Page: 1

Related biology news :

1. Study: Viral reactivation a likely link between stress and heart disease
2. Imaging technology to improve survival of ischemic disease patients
3. Mannotriose promotes survival of hippocampal neurons
4. Researchers create largest evolutionary timetree of land plants to investigate traits that permit survival in cold climates
5. Blocking tumor-associated macrophages decreased glioblastomas growth & extended survival in mice
6. UCSB biomedical scientist discovers a new method to increase survival in sepsis
7. Study examines potential evolutionary role of sexual regret in human survival and reproduction
8. SIGNAL found to enhance survival of new brain cells
9. Sex over survival: Reproductive trait in fish impedes tissue regeneration
10. Biological therapy with cediranib improves survival in women with recurrent ovarian cancer
11. Research shows how aspirin may act on blood platelets to improve survival in colon cancer patients
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/31/2016)... 31, 2016   ... the "Company") LegacyXChange is excited to release ... soon to be launched online site for trading 100% ... ) will also provide potential shareholders a sense of ... to an industry that is notorious for fraud. The ...
(Date:3/22/2016)... 2016 According to ... for Consumer Industry by Type (Image, Motion, Pressure, ... & IT, Entertainment, Home Appliances, & Wearable ... 2022", published by MarketsandMarkets, the market for ... USD 26.76 Billion by 2022, at a ...
(Date:3/17/2016)... 17, 2016 ABI Research, the leader ... global biometrics market will reach more than $30 ... from 2015. Consumer electronics, particularly smartphones, continue to ... anticipated to reach two billion shipments by 2021 ... Pavlakis , Research Analyst at ABI Research. "Surveillance ...
Breaking Biology News(10 mins):
(Date:5/5/2016)... ... May 05, 2016 , ... ProMIS Neurosciences (“ProMIS” ... first three targets, it has identified a fourth in a series of novel ... development and progression of Alzheimer’s disease (AD). , “This discovery is ...
(Date:5/4/2016)... , ... May 04, 2016 , ... Proove Biosciences, ... announce a strategic partnership with McGill University . The partnership is designed to ... market in order to help patients in pain. With the new agreement, researchers at ...
(Date:5/4/2016)... York , May 4, 2016 ... Transparency Market Research "Metabolomics Market - Global Industry Analysis, ... the metabolomics market is anticipated to expand at a ... USD 2,494.8 million by 2024. Metabolomics is ... metabolites, within cells, biofluids, tissues or organisms. Together, these ...
(Date:5/3/2016)... , May 3, 2016 ... Chip (Genomics, Drug Discovery, Gene Expression) Lab-on-a-chip ... user (Academics Institutes, Diagnostics Centers), Fabrication Technology ... by MarketsandMarkets, the market is expected to ... USD 7.63 Billion in 2015, growing at ...
Breaking Biology Technology: