Navigation Links
Re-awakening old genes to help in the fight against HIV
Date:4/27/2009

A new vaginal cream containing a reawakened protein could someday prevent the transmission of HIV.

Scientists at the University of Central Florida in Orlando have revived a dormant gene found in humans and coaxed it to produce retrocyclin, a protein that resists HIV.

Lead scientist Alexander Cole used aminoglycosides, drugs commonly used to fight bacterial infections, to trigger the production of the sleeping protein expressed by the retrocyclin gene.

"It could make a huge difference in the fight against HIV," Cole said. "Much more work would be needed to demonstrate the safety and effectiveness of this approach. We would certainly have to have human trials, but these findings represent a promising step in that direction."

Findings from his three-year investigation are published in this month's PLOS Biology, a well-respected scientific journal.

HIV is the virus that causes AIDS. The disease, most often transmitted sexually, affects 4.3 million people worldwide, according to the World Health Organization. About 14,560 people die annually from HIV-related complications each year in the United States alone, according to the Centers for Disease Control.

Dozens of scientists around the world are looking for ways to prevent the transmission of the disease. Cole's journey into this area of research began while he was a postdoctoral fellow in the Department of Medicine at the University of California at Los Angeles. While there, he and his colleagues discovered that similar retrocyclin proteins found in early primates appeared to prevent HIV infections in cell cultures. The same gene exists in humans, but because of a mutation, it no longer produces the protein.

Now, in collaboration with researchers at UCLA, the Centers for Disease Control and his team at UCF, Cole has found that restoring the production of retrocyclins prevents HIV entry. He found a way to get the gene to produce the retrocyclins and then showed that the retrocyclins appear to prevent the transmission of HIV. He applied aminoglycoside antibiotics to vaginal tissues and cervical cells in his lab and found the antibiotic appears to stimulate those cells and tissues to produce retrocyclins on their own.

He said there is a good possibility the aminoglycoside antibiotics will be used in a cream or gel format that could someday be a simple way to prevent the transmission of HIV from men to women.


'/>"/>

Contact: Zenaida Gonzalez Kotala
zkotala@mail.ucf.edu
407-823-6120
University of Central Florida
Source:Eurekalert  

Related biology news :

1. SUMO protein guides chromatin remodeler to suppress genes
2. Major international study challenges notions of how genes are controlled in mammals
3. Findings show insulin -- not genes -- linked to obesity
4. Genes from tiny marine algae suggest unsuspected avenues for new research
5. Genes from tiny algae shed light on big role managing carbon in worlds oceans
6. Genes that make bacteria make up their minds
7. Team IDs genesis of mass migrations
8. Hopkins scientists ID 10 genes associated with a risk factor for sudden cardiac death
9. Ten genes identified in connection with sudden cardiac death
10. Genes identified that are linked to spinal disc degeneration
11. Cleft lip and palate: Genes more important than thought?
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Re-awakening old genes to help in the fight against HIV
(Date:4/11/2017)... PALM BEACH GARDENS, Fla. , April 11, ... biometric identity management and secure authentication solutions, today ... million contract by Intelligence Advanced Research Projects Activity ... technologies for IARPA,s Thor program. "Innovation ... the onset and IARPA,s Thor program will allow ...
(Date:4/5/2017)... 2017  The Allen Institute for Cell Science today ... one-of-a-kind portal and dynamic digital window into the human ... first application of deep learning to create predictive models ... and a growing suite of powerful tools. The Allen ... future publicly available resources created and shared by the ...
(Date:3/30/2017)... March 30, 2017  On April 6-7, 2017, Sequencing.com ... Genome hackathon at Microsoft,s headquarters in ... will focus on developing health and wellness apps that ... Hack the Genome is the first hackathon for ... world,s largest companies in the genomics, tech and health ...
Breaking Biology News(10 mins):
(Date:7/20/2017)... ... July 20, 2017 , ... Resoundant, ... radiology and imaging centers around the U.S. that offer MR Elastography for liver ... to needle biopsy for staging liver fibrosis assessment. , “MRE:connect was created ...
(Date:7/20/2017)... DENVER and PLYMOUTH, Minn., July 20, 2017 ... LLC , a personalized genetic evaluations company, today ... under their partnership investigating a genetic mutation implicated ... to extend the partnership for a second case ... Last year, the KCNQ2 Cure Alliance and Pairnomix ...
(Date:7/18/2017)... Basel, Switzerland (PRWEB) , ... July 18, 2017 ... ... for R&D, today announced that Merck, a leading science and technology company, has ... develop innovative therapeutics for the therapeutic areas of Oncology, Immunology, and Neurodegenerative Diseases. ...
(Date:7/17/2017)... ... July 17, 2017 , ... Whitehouse Laboratories ... capabilities to encompass the full series of ISO 80369 standard test procedures. The ... medical device and drug delivery systems. With this recent expansion, Whitehouse Labs becomes ...
Breaking Biology Technology: