Navigation Links
Re-awakening old genes to help in the fight against HIV
Date:4/27/2009

A new vaginal cream containing a reawakened protein could someday prevent the transmission of HIV.

Scientists at the University of Central Florida in Orlando have revived a dormant gene found in humans and coaxed it to produce retrocyclin, a protein that resists HIV.

Lead scientist Alexander Cole used aminoglycosides, drugs commonly used to fight bacterial infections, to trigger the production of the sleeping protein expressed by the retrocyclin gene.

"It could make a huge difference in the fight against HIV," Cole said. "Much more work would be needed to demonstrate the safety and effectiveness of this approach. We would certainly have to have human trials, but these findings represent a promising step in that direction."

Findings from his three-year investigation are published in this month's PLOS Biology, a well-respected scientific journal.

HIV is the virus that causes AIDS. The disease, most often transmitted sexually, affects 4.3 million people worldwide, according to the World Health Organization. About 14,560 people die annually from HIV-related complications each year in the United States alone, according to the Centers for Disease Control.

Dozens of scientists around the world are looking for ways to prevent the transmission of the disease. Cole's journey into this area of research began while he was a postdoctoral fellow in the Department of Medicine at the University of California at Los Angeles. While there, he and his colleagues discovered that similar retrocyclin proteins found in early primates appeared to prevent HIV infections in cell cultures. The same gene exists in humans, but because of a mutation, it no longer produces the protein.

Now, in collaboration with researchers at UCLA, the Centers for Disease Control and his team at UCF, Cole has found that restoring the production of retrocyclins prevents HIV entry. He found a way to get the gene to produce the retrocyc
'/>"/>

Contact: Zenaida Gonzalez Kotala
zkotala@mail.ucf.edu
407-823-6120
University of Central Florida
Source:Eurekalert  

Page: 1 2

Related biology news :

1. SUMO protein guides chromatin remodeler to suppress genes
2. Major international study challenges notions of how genes are controlled in mammals
3. Findings show insulin -- not genes -- linked to obesity
4. Genes from tiny marine algae suggest unsuspected avenues for new research
5. Genes from tiny algae shed light on big role managing carbon in worlds oceans
6. Genes that make bacteria make up their minds
7. Team IDs genesis of mass migrations
8. Hopkins scientists ID 10 genes associated with a risk factor for sudden cardiac death
9. Ten genes identified in connection with sudden cardiac death
10. Genes identified that are linked to spinal disc degeneration
11. Cleft lip and palate: Genes more important than thought?
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Re-awakening old genes to help in the fight against HIV
(Date:10/29/2014)... of stem cell, those referred to as ,facultative, form ... apparently nothing that differentiates these cells from the others. ... retain the capacity to become stem cells again. This ... organ that hosts cells that stimulate tissue growth, thus ... of a transplant. Knowledge of the underlying mechanism ...
(Date:10/29/2014)... – Ghrelin is a hormone released by the stomach ... commonly viewed as a psychoactive substance that primarily affects ... food. , This knowledge, combined with findings from ... has the potential to stimulate alcohol craving. , Dr. ... and found that, as they had anticipated, alcohol craving ...
(Date:10/28/2014)... news release is available in German . ... close relatives, the chimpanzees, acquire sufficient food when times ... National Park in Côte d,Ivoire researchers of the Max ... a clear example of how great apes can acquire ... show that chimpanzees make their sleeping nests more en ...
Breaking Biology News(10 mins):A mechanism that allows a differentiated cell to reactivate as a stem cell revealed 2Ghrelin stimulates an appetite for drinking alcohol 2The early chimp gets the fig 2The early chimp gets the fig 3
... 12, 2011)Regular exercise has proven benefits in preventing ... it tough to meet the American Diabetes Association guidelines ... week. A new study, conducted by researchers at McMaster ... In a small proof-of-principle study in eight type 2 ...
... LANSING, MIWine grape production in the Great Lakes Viticultural ... injury, short and variable growing seasons, and cool, humid ... season cluster rot. Tight-clustered wine grape varieties in the ... as Pinot gris, Pinot noir, Riesling, Seyval, and Vignoles ...
... trillion cells in the adult human body are genetically identical, ... skin cells or neurons, by activating some genes while inhibiting ... individual identity by remembering which genes should be kept on ... of memory is not written directly into the DNA, yet ...
Cached Biology News:Exercising harder -- and shorter -- can help Type 2 diabetes 2Exercising harder -- and shorter -- can help Type 2 diabetes 3Early defoliation of Great Lakes wine grapes tested 2Making copies at the right time 2Making copies at the right time 3
(Date:10/30/2014)... CA (PRWEB) October 30, 2014 ... today that they have manually curated public data source ... non profit customers. the data is now available ... curates and unifies public and internal data sources for ... and knowledge out of the data that becomes more ...
(Date:10/30/2014)... Grace Century portfolio project, Provia Laboratories , ... the Board, to the National Stem Cell Ethics Committee ... by the Ministry of Health on behalf of the Government ... More than a year after Bahamian Parliament passed the ... Christie said the government has completed the accompanying regulations and ...
(Date:10/30/2014)... that devastated a wide swath of Colorado last year ... and other infrastructure had been upgraded or modernized, according ... Denver. , "People need to understand the importance and ... of structural engineering at the CU Denver College of ... "There is an assumption that a bridge will stand ...
(Date:10/27/2014)... YORK , Oct. 27, 2014 Kalorama ... the recent Ebola concern in the United ... the virus.  The healthcare market researcher said the FDA,s Emergency ... in vitro diagnostic tests for the detection of the ... has proved useful.  Kalorama routinely assess the IVD industry ...
Breaking Biology Technology:Rancho BioSciences Manually Curated TCGA Data Sets Available 2Grace Century’s Stem Cell Biobank Project Announces Chairman’s Appointment to National Stem Cell Ethics Committee of The Bahamas 2Grace Century’s Stem Cell Biobank Project Announces Chairman’s Appointment to National Stem Cell Ethics Committee of The Bahamas 3CU Denver study says upgrading infrastructure could reduce flood damage 2Kalorama: PCR The Go-to Test in Ebola Fight 2Kalorama: PCR The Go-to Test in Ebola Fight 3
... DIEGO, Feb. 10 ADVENTRX Pharmaceuticals, Inc.,(NYSE Alternext ... written,indications of interest from numerous companies representing a ... evaluating all proposals and,options. In December 2008, ... range,of strategic options, including the sale or disposition ...
... OrthoCare Innovations, LLC is pleased,to announce that former ... Nelson, MD have joined its board of medical ... former Medicare directors to the,Centers for Medicare and ... Carrier), will also consult with the,Company on issues ...
... Feb. 10 /PRNewswire-Asia/ -- Sundia MediTech, a CRO,company ... based in Florida,U.S.A. jointly announced their 2 year ... International Conference yesterday in San Diego,USA. So far ... 2,more candidates to be identified within the next ...
Cached Biology Technology:ADVENTRX Provides Update on Strategic Transaction Process 2ADVENTRX Provides Update on Strategic Transaction Process 3ADVENTRX Provides Update on Strategic Transaction Process 4Former SADMERC Medical Directors Join OrthoCare Innovations as Medical and Scientific Advisory Board Members and Strategic Advisors 2Sundia MediTech and Xcovery Announce Big Success in Drug Discovery 2
Edited by Benjamin Lewin (1997) • This book gives an integrated account of the structure and function of genes in both prokaryotic organisms and is thoroughly up to date with the latest thinking...
... TOPO Cloning is the ... for cloning PCR products. ... Zero Blunt TOPO vectors ... activated with topoisomerase I. ...
...
Applications: ISH...
Biology Products: