Navigation Links
Re-awakening old genes to help in the fight against HIV
Date:4/27/2009

A new vaginal cream containing a reawakened protein could someday prevent the transmission of HIV.

Scientists at the University of Central Florida in Orlando have revived a dormant gene found in humans and coaxed it to produce retrocyclin, a protein that resists HIV.

Lead scientist Alexander Cole used aminoglycosides, drugs commonly used to fight bacterial infections, to trigger the production of the sleeping protein expressed by the retrocyclin gene.

"It could make a huge difference in the fight against HIV," Cole said. "Much more work would be needed to demonstrate the safety and effectiveness of this approach. We would certainly have to have human trials, but these findings represent a promising step in that direction."

Findings from his three-year investigation are published in this month's PLOS Biology, a well-respected scientific journal.

HIV is the virus that causes AIDS. The disease, most often transmitted sexually, affects 4.3 million people worldwide, according to the World Health Organization. About 14,560 people die annually from HIV-related complications each year in the United States alone, according to the Centers for Disease Control.

Dozens of scientists around the world are looking for ways to prevent the transmission of the disease. Cole's journey into this area of research began while he was a postdoctoral fellow in the Department of Medicine at the University of California at Los Angeles. While there, he and his colleagues discovered that similar retrocyclin proteins found in early primates appeared to prevent HIV infections in cell cultures. The same gene exists in humans, but because of a mutation, it no longer produces the protein.

Now, in collaboration with researchers at UCLA, the Centers for Disease Control and his team at UCF, Cole has found that restoring the production of retrocyclins prevents HIV entry. He found a way to get the gene to produce the retrocyc
'/>"/>

Contact: Zenaida Gonzalez Kotala
zkotala@mail.ucf.edu
407-823-6120
University of Central Florida
Source:Eurekalert  

Page: 1 2

Related biology news :

1. SUMO protein guides chromatin remodeler to suppress genes
2. Major international study challenges notions of how genes are controlled in mammals
3. Findings show insulin -- not genes -- linked to obesity
4. Genes from tiny marine algae suggest unsuspected avenues for new research
5. Genes from tiny algae shed light on big role managing carbon in worlds oceans
6. Genes that make bacteria make up their minds
7. Team IDs genesis of mass migrations
8. Hopkins scientists ID 10 genes associated with a risk factor for sudden cardiac death
9. Ten genes identified in connection with sudden cardiac death
10. Genes identified that are linked to spinal disc degeneration
11. Cleft lip and palate: Genes more important than thought?
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Re-awakening old genes to help in the fight against HIV
(Date:1/22/2015)... , Jan. 15, 2015  BellBrook Labs, a leader ... announced the launch of a TR-FRET (time resolved ... Transcreener UDP Assay, a high throughput screening assay ... assay will allow for sensitive detection of hundreds ...
(Date:1/22/2015)... 20, 2015 NXT-ID, Inc. (NASDAQ: NXTD and NXTDW) ... on the recent success of the Wocket™ smart wallet at CES 2015 ... wallet was named as one of the "11 Hot Products at CES" ... Launched At CES So Far" by Newseveryday.com and "The top 10 gadgets ...
(Date:1/22/2015)... Jan. 21, 2015  Analyst Report Issued by Small Cap IR. ... showed that planet-wide, transactions at merchants on the leading payment ... number of credit, debit, and prepaid cards reached 6.54 billion.  ... of fraudulent card usage in 2012, and credit and debit ...
Breaking Biology News(10 mins):BellBrook Labs Launches a High Throughput Screening Assay for Glycosyltransferases with TR-FRET Readout 2CES Response for NXT-ID's Wocket Smart Wallet Kicks Off 2015 2CES Response for NXT-ID's Wocket Smart Wallet Kicks Off 2015 3$4.80 Near Term Price Target with "Buy" given by CapRock Research for NXT-ID, Inc. (NASDAQ: NXTD) issued by Small Cap IR 2
... May Control Staph Infections in Humans Including MRSA ... bacteriophage active against Staphylococcus aureus, including methicillin-resistant strains, ... their findings in the August 2007 issue of ... aureus is a highly flexible and potentially dangerous ...
... papermaking industry,s black liquor waste into synthesis gas is a ... footprint of coal-to-liquid processes, and can produce a fuel versatile ... to a team of Penn state engineers. "Black liquor is ... of fuel science. "But it has more energy value as ...
... Current Biology, a publication of Cell Press, reports some of ... that men and women differ when it comes to their ... prefer pinkor at least a redder shade of bluethan men ... were surprised at how robust they were, given the simplicity ...
Cached Biology News:Tips from the Journals of the American Society for Microbiology 2Tips from the Journals of the American Society for Microbiology 3Coal and black liquor can produce energy from papermaking 2Girls prefer pink, or at least a redder shade of blue 2
(Date:3/4/2015)... CALGARY , March 4, 2015 /CNW/ ... that it has completed a collaborative research ... quantitative analytics.  Using Fast Collective Evolution Technology ... dataset including all measurements obtained from each ... Company,s Phase 2 clinical trials ASSERT, SUSTAIN ...
(Date:3/4/2015)... March 04, 2015 Proove ... Personalized Medicine, is excited to announce the launch ... to Optimize the Management of Pain”. , The ... Medscape.com for the next year. The focus of ... to recognize inadequate pain treatments, integrate appropriate pain ...
(Date:3/4/2015)... 2015  BioClinica®, Inc., a leading specialty ... announced that clinical trial professionals representing 20 ... annual European User Conference in ... use of its eClinical technologies to overcome ... the Microsoft Office-Smart OnPoint CTMS; Express EDC; ...
(Date:3/4/2015)... Jose, California (PRWEB) March 04, 2015 ... Reaction (PCR) represents one of the fastest growing technologies ... cell biologists in subcellular visualization is driving growth in ... need for deeper understanding of gene expressions will continue ... market. Expanding applications in fields ranging from pharma, biotech, ...
Breaking Biology Technology:Resverlogix Collaborates with Emerald Logic to Identify Factors Driving Drug Response and Efficacy in Phase 2 Program 2Resverlogix Collaborates with Emerald Logic to Identify Factors Driving Drug Response and Efficacy in Phase 2 Program 3Resverlogix Collaborates with Emerald Logic to Identify Factors Driving Drug Response and Efficacy in Phase 2 Program 4Proove Biosciences Launches CME Accredited Program with Medscape 2Proove Biosciences Launches CME Accredited Program with Medscape 3BioClinica Teams With Pharma To Tackle Clinical Trial Challenges In Europe 2BioClinica Teams With Pharma To Tackle Clinical Trial Challenges In Europe 3Focus on Quantifying Nucleic Acid Molecules Spurs Growth in the qPCR & dPCR Instrumentation Market, According to a New Report by Global Industry Analysts, Inc. 2Focus on Quantifying Nucleic Acid Molecules Spurs Growth in the qPCR & dPCR Instrumentation Market, According to a New Report by Global Industry Analysts, Inc. 3Focus on Quantifying Nucleic Acid Molecules Spurs Growth in the qPCR & dPCR Instrumentation Market, According to a New Report by Global Industry Analysts, Inc. 4
... the rap against Midwest technology networking events: you pay to ... you spend the evening talking to all the service providers ... to these things very often. Why dont they go? Because ... meet them at networking events, pitch their services and bombard ...
... the tools your competitor has may be your companys ... Overture allow advertisers to purchase company and product names ... This allows companies to poach potential customers from their ... searches for a competitor by name. , ,The ...
... from an experimental CIMSS satellite. Courtesy of UW-Madison. ... big as the weather, the University of Wisconsin's ... bigger computer. , ,The institute has begun testing its ... supercomputer offered by Silicon Graphics Inc. , a ...
Cached Biology Technology:Wake up and smell the networking coffee 2Wake up and smell the networking coffee 3Wake up and smell the networking coffee 4Beware of trademark poachers in search-engine ads 2Beware of trademark poachers in search-engine ads 3Beware of trademark poachers in search-engine ads 4UW-Madison picks scalable SGI computer to simulate weather 2UW-Madison picks scalable SGI computer to simulate weather 3
... increasing age, the autofluorescent pigment lipofuscin ... cell types, including neurons. The presence ... use of fluorescence microscopy in the ... broad excitation and emission spectra, which ...
... S100 belongs to the family of calcium binding ... S100A is composed of an alpha and beta ... chains. S100 protein is also expressed in ... cells in skin and interdigitating reticulum cells in ...
LEAF™ Purified anti-human/mouse/rat ICOS...
Peptide-affinity Purified Polyclonal Antibody to MTR...
Biology Products: