Navigation Links
Rats move toward the food but do not eat
Date:9/8/2009

COLUMBIA, Mo. Scientists led a rat to the fatty food, but they couldn't make it eat. Using an animal model of binge eating, University of Missouri researchers discovered that deactivating the basolateral amygdala, a brain region involved in regulating emotion, specifically blocked consumption of a fatty diet. Surprisingly, it had no effect on the rat wanting to look for the food repeatedly.

"It appears that two different brain circuits control the motivation to seek and consume," said Matthew Will, assistant professor of psychological sciences in the MU College of Arts and Science and investigator in the Christopher S. Bond Life Sciences Center. "Understanding how this circuit in the brain works may provide insight into the exact networks and chemicals in our brain that determine the factors influencing our feeding habits."

The release of opioids, pleasure chemicals that can lead to euphoria, into the brain produces binge eating in non-hungry rats. Will and his team of researchers determined that deactivating the basolateral amygdala blocked this type of binge eating.

"A key to curbing the obesity epidemic in America is controlling the desire to binge eat," Will said. "Humans have more programming to start and continue eating than to stop eating, especially when they have a bowl of ice cream in front of them. Most of us would finish it even if we weren't hungry."

Deactivating the basolateral amygdala had no effect on feeding in rats that were simply deprived of food for 24 hours. This suggests that the basolateral amygdala is specifically involved in the overconsumption of food based on its palatability or pleasure driven by opioids, rather than the level of hunger.

"The finding that the basolateral amygdala only appears involved in the opioid produced consumption was the most surprising part of the study," Will said. "Normally, if a rat stops eating, they will go lay down and take it easy. In this case, they showed all signs of still wanting to eat, but didn't."

In the past when food availability was scarce, humans may have needed this "binge eating" regulation to eat enough food when it was available. Now, when humans have access to foods high in sugar and fat 24 hours a day, this regulation can cause humans to overeat.


'/>"/>

Contact: Kelsey Jackson
JacksonKN@missouri.edu
573-882-8353
University of Missouri-Columbia
Source:Eurekalert  

Related biology news :

1. Scientists take early steps toward mapping epigenetic variability
2. Toward an explanation for Crohns disease?
3. Gene expression findings a step toward better classification and treatment of juvenile arthritis
4. Toward cheap underwater sensor nets
5. Activated stem cells in damaged lungs could be first step toward cancer
6. Progress toward artificial tissue?
7. Toward a systems biology map of iron metabolism
8. Towards a natural pacemaker
9. Optimum running speed is stride toward understanding human body form
10. Cancer: Another step towards medication
11. Greatest thing since sliced bread: New data offer important clues toward improving wheat yields
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Rats move toward the food but do not eat
(Date:2/16/2017)... FRANCISCO , Feb. 16, 2017  Genos, ... today announced that it has received Laboratory Accreditation ... CAP Accreditation is presented to laboratories that meet ... who demonstrate scientifically rigorous processes. "Genos ... excellence in laboratory practices. We,re honored to be ...
(Date:2/10/2017)... , Feb 10, 2017 ... new report "Personalized Medicine - Scientific and Commercial Aspects" ... ... personalized medicine. Diagnosis is integrated with therapy for selection of ... on early detection and prevention of disease in modern medicine. ...
(Date:2/8/2017)... Feb. 7, 2017 Report Highlights ... The global synthetic-biology market ... billion by 2021, growing at a compound annual growth rate ... overview of the global markets for synthetic biology. - Analyses ... 2016, and projections of compound annual growth rates (CAGRs) through ...
Breaking Biology News(10 mins):
(Date:2/23/2017)... 23, 2017 ... per share data, unaudited)Three Months Ended December 31,Twelve Months ... $         ...   89026%Aldurazyme Net Product Revenue ... Net Product Revenue  756025%297303(2)%Vimizim Net ...
(Date:2/23/2017)... , Feb. 23, 2017  MIODx announced today ... two key immunotherapy technologies from the University of ... a method to monitor a patient for response ... and CTLA-4.  The second license extends the technology ... is likely to have an immune-related adverse event ...
(Date:2/23/2017)... Feb. 23, 2017  Imanis Life Sciences announced ... of oncolytic vaccinia viruses for virotherapy research. These ... of Genelux,s proprietary, vaccinia virus-based technology platform for ... enter into a partnership with Genelux to offer ... viruses for use in research," said Dr. ...
(Date:2/23/2017)... Ind. (PRWEB) , ... February 23, 2017 , ... ... Award during the 12th annual Inventors Recognition Reception at Purdue Research Park ... to a faculty member in recognition of outstanding contributions to, and success with, ...
Breaking Biology Technology: