Navigation Links
Rats! Humans and rodents process their mistakes
Date:10/20/2013

PROVIDENCE, R.I. [Brown University] People and rats may think alike when they've made a mistake and are trying to adjust their thinking.

That's the conclusion of a study published online Oct. 20 in Nature Neuroscience that tracked specific similarities in how human and rodent subjects adapted to errors as they performed a simple time estimation task. When members of either species made a mistake in the trials, electrode recordings showed that they employed low-frequency brainwaves in the medial frontal cortex (MFC) of the brain to synchronize neurons in their motor cortex. That action correlated with subsequent performance improvements on the task.

"These findings suggest that neuronal activity in the MFC encodes information that is involved in monitoring performance and could influence the control of response adjustments by the motor cortex," wrote the authors, who performed the research at Brown University and Yale University.

The importance of the findings extends beyond a basic understanding of cognition, because they suggest that rat models could be a useful analog for humans in studies of how such "adaptive control" neural mechanics are compromised in psychiatric diseases.

"With this rat model of adaptive control, we are now able to examine if novel drugs or other treatment procedures boost the integrity of this system," said James Cavanagh, a co-lead author of the paper who was at Brown when the research was done and has since become an Assistant Professor of psychology at the University of New Mexico. "This may have clear translational potential for treating psychiatric diseases such as obsessive compulsive disorder, depression, attention deficit hyperactivity disorder, Parkinson's disease and schizophrenia"

To conduct the study, the researchers measured external brainwaves of human and rodent subjects after both erroneous and accurate performance on the time estimation task. They also measured th
'/>"/>

Contact: David Orenstein
david_orenstein@brown.edu
401-863-1862
Brown University
Source:Eurekalert  

Page: 1 2

Related biology news :

1. UC Santa Barbara researchers discover genetic link between visual pathways of hydras and humans
2. Bartonella infection associated with rheumatoid illnesses in humans
3. More than 1 way to be healthy: Map of bacterial makeup of humans reveals microbial rare biosphere
4. The Iberian wolf lives close to humans more for refuge than for prey
5. Hormone in fruit flies sheds light on diabetes cure, weight-loss drug for humans
6. Relieving plant stress could eventually help humans relax
7. Humans were already recycling 13,000 years ago
8. Pigs look healthy but test positive for flu at fairs; transmission seen between pigs and humans
9. Obese dogs at risk of health condition experienced by humans
10. Alzheimers disease in mice alleviated promising therapeutic approach for humans
11. New coronavirus has many potential hosts, could pass from animals to humans repeatedly
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Rats! Humans and rodents process their mistakes
(Date:9/18/2014)... too stressed they are often grouchy, grumpy, nasty, distracted ... at EPFL have just highlighted a fundamental synaptic mechanism ... loss of social skills and cognitive impairment. When triggered ... in the brain. This was revealed by a work ... Sandi,s team went to look for answers in a ...
(Date:9/18/2014)... protective tentacles of host anemones, but new research shows ... across the open ocean. Although the process of long-distance ... the first time that the high level exchange of ... Steve Simpson, Senior Lecturer in Marine Biology and Global ... the Australian Research Council Centre of Excellence for Coral ...
(Date:9/17/2014)... and his doctoral student have designed a device based ... from fog and dew., The device could provide water ... the globe., Cheng Luo, professor in the Mechanical & ... the same College of Engineering department, published "Bioinspired Plate-Based ... (American Chemical Society) Applied Materials & Interfaces ...
Breaking Biology News(10 mins):How stress tears us apart 2Expedition finds Nemo can travel great distances to connect populations 2Expedition finds Nemo can travel great distances to connect populations 3Shorebird's beak inspires UT Arlington research on water collection 2
... range of data file formats (including video and audio files), and ... format, as well as more traditional formats such as graphs and ... data (as a zip file), even if they don,t have the ... the data, share it on social media sites and view metrics, ...
... carbon dioxide accelerate carbon cycling and soil carbon loss in ... found. , The new evidence supports an emerging view that ... the atmosphere, much of the carbon is being stored in ... soils. , Richard P. Phillips, lead author on the paper ...
... species of monkey flower, created by the union of ... a stream in Scotland. Genetic changes in this attractive yellow-flowered hybrid ... example of a brand new species that has originated in the ... some crops are thought to have originated in this way, yet ...
Cached Biology News:Rising carbon dioxide in atmosphere also speeds carbon loss from forest soils, IU-led research finds 2Rare glimpse into the origin of species 2
(Date:9/18/2014)... September 18, 2014 ... http://www.researchandmarkets.com/research/czvg3s/biocompatible ) has announced the addition ... Global Strategic Business Report" report ... ,This report analyzes the worldwide markets ... by the following Product Segments: Polymeric ...
(Date:9/18/2014)... On Tuesday, Secretary of Energy Ernest Moniz ... National Lab Day on the Hill. The event highlighted ... system. Durbin and Risch also formally launched the Senate ... the reach of the national labs as leaders in ... of our nation's most pressing challenges. , "The national ...
(Date:9/18/2014)... 2014 Research and Markets ... N-acetylcysteine Industry Report 2014" report to their ... Report 2014 is a professional and in-depth study ... industry. The report provides a basic ... and industry chain structure. The N-acetylcysteine market analysis ...
(Date:9/18/2014)... , Sept. 18, 2014 Research and ... "Global Companion Diagnostics (Polymerase Chain Reaction, In-situ hybridization, Immunohistochemistry) ... to their offering. The global companion ... of 22.7% from 2014 to 2019. Factors such as ... adoption of companion diagnostics by the pharmaceutical industry, support ...
Breaking Biology Technology:Biocompatible Materials - Global Strategic Business Report 2014 2Biocompatible Materials - Global Strategic Business Report 2014 3Lab Day Highlight Labs' Contribution to U.S. Competitiveness and Innovation 2Lab Day Highlight Labs' Contribution to U.S. Competitiveness and Innovation 3Global N-acetylcysteine Industry Report 2014 2Global Companion Diagnostics (Polymerase Chain Reaction, In-situ hybridization, Immunohistochemistry) Market - Trends & Forecasts to 2019 2Global Companion Diagnostics (Polymerase Chain Reaction, In-situ hybridization, Immunohistochemistry) Market - Trends & Forecasts to 2019 3
... Age of Unreason," an important book in which author ... business-affecting change. Though an economist, Handy could not have ... our current recession, yet he offers a prescient perspective ... a shift from manufacturing- to a knowledge-based economy. , ...
... Medical Systems today introduced AutoBone, a clinical ... clinicians to remove the bone structure from diagnostic ... hidden in traditional imaging views, which optimizes surgical ... less-invasive clinical procedures and increased diagnostic confidence. ...
... GE Medical Systems , has signed a clinical trial ... the National Cancer Institute (NCI) for multi-site clinical trials ... tomography (PET), applied to the management of patients with ... to image DNA synthesis, showing high contrast in the ...
Cached Biology Technology:The Molecular Organization 2The Molecular Organization 3GE Medical Systems Signs Clinical Trial with National Cancer Institute 2