Navigation Links
Rare pregnancy condition programs babies to become overweight in later life
Date:6/24/2013

he offspring, the researchers created a mouse model of the disease by supplementing the diet of normal mice with cholic acid, a type of bile acid. Mice born from these pregnancies were also more prone to obesity and diabetes, confirming the findings from the human studies.

Dr Georgia Papacleovoulou, first author of the study from Imperial College London, explains: "This is the first evidence that cholestasis during pregnancy can have long-term effects on the health of the baby as it grows into adulthood."

Both the human and mouse studies revealed an increase in fats and excessive cholesterol transport in placentas from mothers with cholestasis compared with healthy mothers, consistent with a disruption in the metabolism of fats. The researchers propose that this shift in the nutrients supplied by the mother is likely to affect the energy balance in the unborn baby, something that could continue after the baby is born, resulting in an altered metabolism in adult life that could give rise to diseases such as obesity and diabetes.

Using another mouse model, the researchers showed that feeding bile salts to mice during pregnancy resulted in chemical changes to the DNA of the offspring, or epigenetic changes.

Professor Catherine Williamson, lead author of the study from Imperial College London and King's College London, said: "We don't yet know the exact mechanisms of how the increase in bile salts in the mothers' blood programs the unborn baby towards metabolic disease but it seems likely that epigenetics plays a role. We need to do more experiments to work out how these chemical changes to the DNA of the baby affect its ability to metabolise fats."

Dr Alison Cave, Head of Cellular, Developmental and Physiological Sciences at the Wellcome Trust, said: "We're in the grips of an epidemic of obesity and diabetes and this study adds to the increasing evidence which suggests that it may not be explained by unhealthy diets an
'/>"/>

Contact: Jen Middleton
j.middleton@wellcome.ac.uk
44-207-611-7262
Wellcome Trust
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Women & Infants participating in study of treatment of common viral infection in pregnancy
2. Anti-HIV drug use during pregnancy does not affect infant size, birth weight
3. Tattoo-like devices for wireless pregnancy monitoring
4. New discovery provides insight on long-standing pregnancy mystery
5. Mild thyroid dysfunction in early pregnancy linked to serious complications
6. Study offers new insights into the effects of stress on pregnancy
7. UCLA study looks at why heart attacks cause so much more damage in late pregnancy
8. A diet high in choline during pregnancy may mean less stress for baby
9. Study implicates marijuana use in pregnancy problems
10. Eating well during pregnancy reduces babys obesity risk regardless of moms size
11. UCLA Receives $46 Thousand Check for Groundbreaking Research on Debilitating Pregnancy Disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/14/2014)... 14, 2014 MedNet Solutions , ... clinical study management systems, is pleased to announce ... firm focused on software-as-a-service (SaaS) and Internet-based businesses, ... Solutions.  This funding, representing the first major outside ... in supporting the ongoing growth and development of ...
(Date:7/14/2014)... July 14, 2014 Research and Markets ... Testing 2014: Applications for Microfluidic Technologies" report to their ... POC testing based on microfluidic technology is expected to grow ... a CAGR 2014 - 2019 of 23%. Major diagnostics companies ... Abaxis, etc.) have realized the potential of rapid molecular diagnostic ...
(Date:7/14/2014)... deadly diseases and infections, such as tuberculosis and ... speed up the drug discovery process. , In ... , University of Illinois researchers developed a new ... produced by bacteria. , Past techniques involved screening ... product, said principal investigator Doug Mitchell, assistant professor ...
Breaking Biology News(10 mins):Arrowroot Capital Invests $4 Million In MedNet Solutions 2Arrowroot Capital Invests $4 Million In MedNet Solutions 3Applications for Microfluidic Technologies in Point of Care Testing: 2014 Report 2Applications for Microfluidic Technologies in Point of Care Testing: 2014 Report 3Innovative technique may transform the hunt for new antibiotics and cancer therapies 2Innovative technique may transform the hunt for new antibiotics and cancer therapies 3
... June 5, 2012 /PRNewswire-iReach/ -- Global Information ... discounted registration for three important international healthcare and biotechnology ... Antibody Engineering Summit 2012 November 6 ... Annual Protein & Antibody Engineering Summit (PEGS Europe) presents ...
... Ph.D., Wellcome Trust Principal Research Fellow and Head, ... of Emmanuel College, Cambridge, has been bestowed the ... recognizing exemplary leadership in the international microbiological community. ... of Virginia, says Smith is "internationally recognized as ...
... (June 6, 2012) Two studies appearing in the ... freely available on-line at http://www.ingentaconnect.com/content/cog/ct/ , evaluate the ... pancreatic tissues, in addition to a clinical study that ... islets are better than cultured islets , A ...
Cached Biology News:Early Bird Offers on Healthcare and Biotechnology Conferences, Save Up To 20% by Registering with Global Information 2Early Bird Offers on Healthcare and Biotechnology Conferences, Save Up To 20% by Registering with Global Information 3The American Society for Microbiology honors Geoffrey L. Smith 2Some factors that impact islet transplantation explored in Cell Transplantation papers 2Some factors that impact islet transplantation explored in Cell Transplantation papers 3Some factors that impact islet transplantation explored in Cell Transplantation papers 4
(Date:7/10/2014)... -- Kainos Capital, a firm specializing in acquiring and managing ... acquired the Slim-Fast brand from Unilever. Unilever will retain ... transaction were not disclosed. Slim-Fast is a ... ready-to-drink shakes, powders, bars and snacks to retail customers ... the United Kingdom and Ireland.  ...
(Date:7/10/2014)... Research and Markets ( http://www.researchandmarkets.com/research/s3bqj2/photonic ) ... Photonic Integrated Circuit (Monolithic Integration, Hybrid Integration, Module ... to their offering. ... integration traces its roots in the latter half ... integration went unexplored and unfulfilled for several decades ...
(Date:7/10/2014)... 15, 2014 -- According to the International Atomic ... security comes from terrorists acquiring sufficient quantities of ... a crude nuclear explosive device. The IAEA also ... have involved gram-level quantities, which can be challenging ... to a new study appearing this week in ...
(Date:7/10/2014)... June 17, 2014 Using microscopic polymer light ... gases, researchers at MIT,s Quantum Photonics Laboratory have ... in the parts-per-billion range. Optical sensors are ideal ... high signal-to-noise ratio, compact, lightweight nature, and immunity ... sensors had been developed before, the MIT team ...
Breaking Biology Technology:Kainos Capital Acquires Slim-Fast From Unilever 2International Photonic Integrated Circuit (Monolithic Integration, Hybrid Integration, Module Integration) Market - Forecasts to 2019 2Sensitive detection method may help impede illicit nuclear trafficking 2Swell new sensors 2
... BioPharma Have Entered into an Agreement Under, Which Genmab Will ... ... USA, COPENHAGEN, Denmark and REDWOOD CITY, California, February 21, ... ) announced today that they have entered into an agreement,under ...
... a,global provider of products and services that improve the ... by the New York,Department of Health for its public ... to maintain emergency response readiness, New,York has purchased more ... two years., Cardinal Health has already shipped 850 ...
... (OTC,Bulletin Board: SNKTY), a Life Sciences company engaged ... of healthy aging, today announced,that Dr. Mark Nestor ... Symposium in Miami., In his presentation to ... attributes of Pyratine-6(TM) for the treatment of,photodamaged skin ...
Cached Biology Technology:Genmab and PDL BioPharma Sign Purchase Agreement for Antibody Manufacturing Facility 2Genmab and PDL BioPharma Sign Purchase Agreement for Antibody Manufacturing Facility 3Genmab and PDL BioPharma Sign Purchase Agreement for Antibody Manufacturing Facility 4Genmab and PDL BioPharma Sign Purchase Agreement for Antibody Manufacturing Facility 5New York Strengthens Emergency Preparedness with Cardinal Health Ventilators 2Dr. Mark Nestor Presents on Pyratine-6(TM) at the South Beach Symposium 2Dr. Mark Nestor Presents on Pyratine-6(TM) at the South Beach Symposium 3
... Detection System combines the indirect labeling ... and Signets unique formulation of ultra ... reliablility. Signet reagents will achieve excellent ... automated protocols. ,Signets USA Detection ...
6X Loading Buffer is intended for gel electrophoresis of DNA fragments or PCR products....
6X DNA Gel Loading Buffer is intended for gel electrophoresis of DNA fragments or PCR products....
Makes gels easy to load and track during electrophoresis. 10X concentrate of Bromophenol Blue, Xylene Cyanol, glycerol solution in TE...
Biology Products: