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Rare genetic mutations protect against hypertension
Date:4/6/2008

out functional mutations -- for understanding individual risk of disease.

A major question about the genetic underpinnings of hypertension and other common diseases has been whether these are accounted for by common or rare DNA variations, said Lifton. Our study demonstrates the role of rare variation, showing that effects of rare mutations in these three genes cause relatively large effects, with clinically significant effects in individual patients. These findings suggest that much of the variation in common disease risk for hypertension and other diseases will be accounted for by rare (genetic) variants.


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Contact: Jim Keeley
keeleyj@hhmi.org
301-215-8858
Howard Hughes Medical Institute
Source:Eurekalert

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