Navigation Links
Rare genetic disorder gives clues to autism, epilepsy, mental retardation
Date:9/23/2008

different parts of the brain," Sahin says. "In mouse models of TSC, we're seeing an exuberance of connections."

In laboratory experiments, the researchers were able to limit multiple axon formation by using the cancer drug rapamycin to suppress production of a protein called SAD-A kinase. This protein is produced in excess when the TSC1 and TSC2 genes are inactivated, and is found in abundance in the abnormally large cells that make up tubers.

Because increased SAD-A is associated with increased axon growth, the researchers also speculate that the TSC pathway could be manipulated to regenerate or repair axons lost or damaged in spinal cord or other nerve injuries.

"These findings provide a potential explanation for neurological abnormalities in TSC patients and perhaps in people without TSC," says He. "The challenge remains as to how to treat these conditions. We have some clues but a lot more research needs to be done."


'/>"/>

Contact: James Newton
james.newton@childrens.harvard.edu
617-919-3110
Children's Hospital Boston
Source:Eurekalert

Page: 1 2

Related biology news :

1. Childrens Hospital researchers identify genetic mutation that may predict organ rejection
2. K-State professors USDA research shows mad cow disease also caused by genetic mutation
3. How do race, genetics and health-care disparities affect spread of HIV?
4. Exploding chromosomes fuel research about evolution of genetic storage
5. Genetics reveals big fish that almost got away
6. Scientists discover major genetic cause of colorectal cancer
7. Seed Wars: Controversies and Cases on Plant Genetic Resources and Intellectual Property
8. Study helps pinpoint genetic variations in European Americans
9. Study finds connections between genetics, brain activity and preference
10. Genetic data promises new future for kiwi fruit
11. Advances in the field of schizophrenia research: New genetic factors identified
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/10/2014)... 10, 2014) Consuming a whole fresh avocado with ... enhanced provitamin A carotenoid (alpha- and beta-carotene) absorption and ... vitamin A, according to new research (1) published ... , Vitamin A is involved in reproductive health ... and vision; and has antioxidant properties. Provitamin A carotenoids, ...
(Date:7/10/2014)... University Medical Center (CUMC) researchers have created a way ... pigmentosa (RP), a leading cause of vision loss. The ... induced pluripotent stem (iPS) cell technology to transform skin ... a patient-specific model for disease study and preclinical testing. ... Tsang, MD, PhD, showed that a form of RP ...
(Date:7/9/2014)... of protein, that,s not why the Millennials are eating it, ... Club Inc.,s annual International Recognition Days convention July 10th in ... want dishes that are quick, easy to cook and that ... care less about any health benefits of Tofu," said lead ... and because it,s quick to cook and it,s filling.", The ...
Breaking Biology News(10 mins):New research: Fresh avocado enhances absorption of essential nutrients for healthy living 2Patient-specific stem cells and personalized gene therapy 2Patient-specific stem cells and personalized gene therapy 3
... the National Center for Supercomputing Applications was barely ... Connection Machines, CM-2, was just being installed, and ... University of Illinois, launched the Theoretical Biophysics Group ... analytical tools of physics and chemistry, coupled with ...
... Heidelberg, Germany, September 17th, 2009 / b3c newswire ... station PROcellcare based on a 96 well plate. ... licensing partner EMBL (European Molecular Biology Laboratory). ... live cells (in vitro) under the microscope with ...
... Researchers at the Department of Biochemistry and Molecular ... revealed the process by which proteins with a ... lateral sclerosis, familial amyloidotic polyneuropathy, familial amyloidotic cardiomyopathy, ... carried out an analysis of their 3D structure ...
Cached Biology News:Symposium marks 20th anniversary of Theoretical and Computational Biophysics Group 2Symposium marks 20th anniversary of Theoretical and Computational Biophysics Group 3Symposium marks 20th anniversary of Theoretical and Computational Biophysics Group 4New Automatic cell feeding station PROcellcare for life cell imaging 2Mechanism related to the onset of various genetic diseases revealed 2Mechanism related to the onset of various genetic diseases revealed 3
(Date:1/14/2014)... January 14, 2014 iLab Solutions, the leader ... the new Director of Product Strategy. In this role, Michelle ... iLab sub-teams to guide in the development of iLab products. ... the maximum possible benefit to the scientific community by offering ...
(Date:1/14/2014)... 14, 2014  RXi Pharmaceuticals Corporation (OTCQX: RXII), a ... innovative therapies addressing major unmet medical needs using ... Notice of Allowance from the United States Patent ... compounds (sd-rxRNA®), for the treatment of fibrosis. The ...
(Date:1/14/2014)... , Jan. 14, 2014   Kinaxis ®, provider of ... ) and sales and operations planning ( S&OP ) service, ... Biomanufacturing Summit , which will be held at the Hilton ... conference, join Kinaxis customer Elisabeth Kaszas , Director of ...
(Date:1/14/2014)... 14, 2014 Kerr Corporation, a leading manufacturer ... additional how-to information about dual arch impressions on its dental ... Arch Impressions,” the blog entry serves up a list of ... a step-by-step demonstration by Dr. David Little as he crafts ...
Breaking Biology Technology:iLab Solutions Announces Michelle Detwiler as the New Director of Product Strategy 2RXi Pharmaceuticals Receives US Notice of Allowance for a Key Patent Relating to its Self-Delivering Technology with sd-rxRNAs targeting CTGF, including RXI-109, for the Treatment of Fibrotic Disorders 2RXi Pharmaceuticals Receives US Notice of Allowance for a Key Patent Relating to its Self-Delivering Technology with sd-rxRNAs targeting CTGF, including RXI-109, for the Treatment of Fibrotic Disorders 3Event Alert: Kinaxis Customer to Present at the Biomanufacturing Summit "Supply Chain: Improving Network Effectiveness" 2
... partnership with Baxa Corporation, announces the, availability of ... laws and regulations related to sterile ... 30 Baxa Corporation announces,the availability of a ... for sterile compounding and USP ,compliance. The ...
... Inc., an innovative provider of advanced neuromodulation products designed to ... HealthSouth Corporation, the nation’s largest provider of inpatient rehabilitative healthcare ... Rehabilitation System and the NESS L300™ Foot Drop System to ... ...
... ALS CLINICALS AND DRUG DEVELOPMENT, ROCKVILLE, Md., ... CUR ) announced that Dr. Thomas Hazel ... Research. He will be,working with Dr. Karl Johe, ... company,s upcoming clinical trial for ALS,(Amytrophic Lateral Sclerosis, ...
Cached Biology Technology:CriticalPoint(TM) Introduces Crosswalk Tool for Sterile Compounding Regulatory Requirements 2CriticalPoint(TM) Introduces Crosswalk Tool for Sterile Compounding Regulatory Requirements 3 Bioness Announces NESS H200 and L300 Systems to Be Available at 88 HealthSouth Hospitals Nationwide 2 Bioness Announces NESS H200 and L300 Systems to Be Available at 88 HealthSouth Hospitals Nationwide 3Neuralstem Fills Key Product Development Position 2
... 26] to Presenilin 2 Alzheimer's disease ... the disease carry mutations in the presenilin ... protein (APP). These disease-linked mutations result in ... amyloid-beta (main component of amyloid deposits found ...
One-step, microplate or cuvet, colorimetric, linear detection range 0.7 mg/dL to 35 mg/dL. Procedure: 5 min....
One-step, microplate or cuvet, colorimetric, linear detection range 0.9 mg/dL to 200 mg/dL. Procedure: 2 min....
[5,6,8,9,12,14,15(n)-3H]Prostaglandin D2, 925 kBq, 25 uCi. Methanol:water:acetonitrile (3:2:1) solution.> 3.0 TBq/mmol, > 80 Ci/mmol.3.7 MBq/ml, 100 uCi/ml. Category: Radiochemicals &Radiation Safety...
Biology Products: