Navigation Links
Rare genetic disease offers insight into common cancers

Fanconi anemia is a recessive genetic disorder affecting 1 in 350,000 babies, which leaves cells unable to repair damaged DNA. This lack of repair puts Fanconi anemia patients at high risk for developing a variety of cancers, especially leukemias and head and neck cancer. Cruelly, the condition also nixes the use of an entire class of cancer drugs, namely drugs like mitomycin C that act by encouraging DNA to crosslink together like sticky strands of bread dough generally, healthy cells can repair a few crosslinks whereas cancer cells cannot and so are killed. However, Fanconi anemia patients are unable to repair the damage done to healthy or cancerous cells done by these drugs and so treatment with mitomycin C is frequently fatal.

A University of Colorado Cancer Center study funded by the Fanconi Anemia Research Fund explored the effectiveness of a novel agent in preventing cancer in this population namely, resveratrol as found in red wine. The results of this study will be presented at the 24th annual Fanconi Anemia Research Fund Scientific Symposium, September 27-30 at the Grand Hyatt Hotel in Denver, CO.

In fact, the findings may go far past Fanconi anemia.

"One of the Fanconi genes that is lost is BRCA2 the same genetic loss that causes many breast cancers," says Robert Sclafani, PhD, investigator at the University of Colorado Cancer Center and professor of biochemistry and molecular genetics at the CU School of Medicine. "So one mystery is why Fanconi anemia patients don't get breast cancer. In Fanconi, every cell in the body is missing that gene Fanconi is a very rare thing but it's telling us something about cancers that aren't so rare."

Sclafani's had already shown the effectiveness of resveratrol in treating head and neck cancer, and in this study explored the effect of resveratrol in Fanconi cell lines could it prevent cancer by eliminating the cancer cells in Fanconi patients?

"It turns out that regular Fanconi cells aren't sensitive to resveratrol in the way they're sensitive to drugs like mitomycin C," Sclafani says. Instead, Sclafani hopes that additional mutations found in Fanconi head and neck cancer cells will make them sensitive to resveratrol in a way normal Fanconi cells are not. His recent results will be presented at the upcoming meeting.

"It's an interesting population," says Sclafani "and one that may hold information about many kinds of cancer."


Contact: Garth Sundem
University of Colorado Denver

Related biology news :

1. Zülch Prize 2012 for founders of optogenetics
2. NIH-funded researchers restore sense of smell in mice using genetic technique
3. A new light shed on genetic regulations role in the predisposition to common diseases
4. Biophysicists unravel secrets of genetic switch
5. Early menopause: A genetic mouse model of human primary ovarian insufficiency
6. Vitamin B12 deficiency: Tracking the genetic causes
7. U of M researchers: Newly discovered genetic markers could signal colon cancer development
8. Ecologist: Genetically engineered algae for biofuel pose potential risks that should be studied
9. Scientists use light to tag and track genetic processes
10. New Genetics educational resource promotes active learning
11. Genetics Society of America’s GENETICS journal highlights for August 2012
Post Your Comments:
(Date:5/16/2016)...   EyeLock LLC , a market leader of ... an IoT Center of Excellence in Austin, ... of embedded iris biometric applications. EyeLock,s iris ... security with unmatched biometric accuracy, making it the most ... EyeLock,s platform uses video technology to deliver a fast ...
(Date:4/28/2016)... First quarter 2016:   , Revenues amounted ... quarter of 2015 The gross margin was 49% (27) ... the operating margin was 40% (-13) Earnings per share ... operations was SEK 249.9 M (21.2) , Outlook   ... M. The operating margin for 2016 is estimated to ...
(Date:4/15/2016)... -- Research and Markets has announced the ...  report to their offering.  ,      ... gait biometrics market is expected to grow at ... Gait analysis generates multiple variables such ... compute factors that are not or cannot be ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... Seattle, WA (PRWEB) , ... June 23, 2016 ... ... technology, announces the release of its second eBook, “Clinical Trials Patient Recruitment and ... patient recruitment and retention in this eBook by providing practical tips, tools, and ...
(Date:6/23/2016)... - FACIT has announced the creation of a ... Propellon Therapeutics Inc. ("Propellon" or "the Company"), to ... of first-in-class WDR5 inhibitors for the treatment of ... an exciting class of therapies, possessing the potential ... patients. Substantial advances have been achieved with the ...
(Date:6/23/2016)... (PRWEB) , ... June 23, 2016 , ... ... Plate® YM (Yeast and Mold) microbial test has received AOAC Research Institute approval ... of microbial tests introduced last year,” stated Bob Salter, Vice President of Regulatory ...
(Date:6/23/2016)... 23, 2016   EpiBiome , a precision microbiome ... in debt financing from Silicon Valley Bank (SVB). The ... to advance its drug development efforts, as well as ... "SVB has been an incredible strategic partner to ... traditional bank would provide," said Dr. Aeron Tynes ...
Breaking Biology Technology: