Navigation Links
Rare gene glitch may hold clues for schizophrenia -- NIH-funded study
Date:2/24/2011

Scientists are eyeing a rare genetic glitch for clues to improved treatments for some people with schizophrenia even though they found the mutation in only one third of 1 percent of patients.

In the study, funded in part by the National Institutes of Health, schizophrenia patients were 14 times more likely than controls to harbor multiple copies of a gene on Chromosome 7. The mutations were in the gene for VIPR2, the receptor for vasoactive intestinal peptide (VIP) a chemical messenger known to play a role in brain development. An examination of patients' blood confirmed that they had overactive VIP activity.

Discovery of the same genetic abnormality in even a small group of patients buoys hopes for progress in a field humbled by daunting complexity in recent years. The researchers' previous studies had suggested that the brain disorder that affects about 1 percent of adults might, in many cases, be rooted in different genetic causes in each affected individual, complicating prospects for cures.

"Genetic testing for duplications of the VIP receptor could enable early detection of a subtype of patients with schizophrenia, and the receptor could also potentially become a target for development of new treatments," explained Jonathan Sebat, Ph.D., of the University of California, San Diego, who led the research team. "The growing number of such rare duplications and deletions found in schizophrenia suggests that what we have been calling a single disorder may turn out, in part, to be a constellation of multiple rare diseases."

Sebat, a grantee of the NIH's National Institute of Mental Health and colleagues at 14 research centers world-wide report on their findings Feb. 23, 2011, in the journal Nature.

"Although such copy number variations may explain only a small fraction of cases, these rare mutations can yield important clues to the underlying causes of more common forms," noted NIMH Director Thom
'/>"/>

Contact: Jules Asher
NIMHpress@nih.gov
301-443-4536
NIH/National Institute of Mental Health
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Scientists link genetic glitches to common childhood cancer
2. Insects hold atomic clues about the type of habitats in which they live
3. Genetic clues to compulsive, self-injurious behavior in rare childhood disorder
4. Differences in brain development between males and females may hold clues to mental health disorders
5. Bat brains offer clues as to how we focus on some sounds and not others
6. Zebrafish yield clues to how we process visual information
7. UF research gives clues about carbon dioxide patterns at end of Ice Age
8. Genetic markers offer new clues about how malaria mosquitoes evade eradication
9. Barrow scientists uncover clues on inflammation in central nervous system
10. New clues to how cancer-related proteins plasmin, thrombin lose inhibition
11. Scientists reveal important clues to how bacteria and viruses are identified as enemies
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Rare gene glitch may hold clues for schizophrenia -- NIH-funded study
(Date:12/10/2014)... 9, 2014  Valencell, a leader in performance biometric ... staggering demand from its licensees for highly accurate, clinically ... not solely coming from fitness and health sectors, but ... "A wearable is only as useful as the biometric ... ultimate driver in long-term mass consumer adoption of wearable ...
(Date:12/10/2014)... Research and Markets ( http://www.researchandmarkets.com/research/xclcvw/biometrics_market ... "Biometrics Market in Japan 2014-2018" report to ... The integration of biometrics and ... and upgradation of the driver,s license is one ... Besides the aforementioned projects, biometrics is being used ...
(Date:12/5/2014)... -- Tute Genomics, a leader in cloud-based solutions for genome ... led by UK-based Eurovestech. Peak Ventures and a number ... "We are at a pivotal time in ... seeks new approaches for the diagnosis, treatment and prevention ... and CEO of Tute Genomics. "One of the main ...
Breaking Biology News(10 mins):Wearable Technology Products Demand Highly Accurate Biometric Technology 2Biometrics Market in Japan 2014-2018: Key Vendors are DDS, Fujitsu, Hitachi and NEC 2Tute Genomics Raises $2.3 Million to Scale Up Cloud-Based Genome Analytics and Accelerate Personalized Medicine 2Tute Genomics Raises $2.3 Million to Scale Up Cloud-Based Genome Analytics and Accelerate Personalized Medicine 3
... Research at Virginia Commonwealth University Massey Cancer Center ... biochemistry and molecular Biology, discovered a previously unknown mechanism ... to their ability to maintain and grow tumors. Narrowing ... the development of effective therapies for NSCLC and other ...
... ISRAEL, December 2, 2010 -- Intense, individually tailored dietary ... on mortality, according to a new study by researchers ... study just published in the prestigious Journal of ... six months after discharge (11.6 percent) of the control ...
... biomedical imaging, and in particular his pioneering work in ... foundation for applications of this technique in medicine and ... contrast with lower doses of radiation. His research is ... to applications in medical imaging and diagnosis; it could ...
Cached Biology News:VCU Massey discovery could lead to breakthrough for non-small cell lung cancer 2Personalized diets for elderly after hospitalization decreases mortality rates 2Physicist Franz Pfeiffer receives 2011 Leibniz Prize 2
(Date:12/17/2014)... (PRWEB) December 17, 2014 Gene ... that it has entered into a technology access ... (ADM) to apply DNA2.0’s proprietary protein engineering technology, ... process. , “We are extremely excited that the ... platform. This proprietary bioengineering technology has now ...
(Date:12/17/2014)... SOUTH SAN FRANCISCO, Calif. , Dec. 17, ... positive results of a Phase 2 study evaluating ... for the treatment of patients with severe, chronic ... the current standard of care, including topical steroids ... endpoint was percent change in Visual Analog Scale ...
(Date:12/15/2014)...  GlassesOff Inc. (OTCBB: GLSO) announced today the appointment ... director of the Company,s Board of Directors. ... its CEO until its acquisition by Stanley Black ... Recognized as the inventor of the first Wi-Fi-based Active ... -based RFID solutions focused on improving operational efficiency, safety ...
(Date:12/13/2014)... (PRWEB) December 12, 2014 Clarassance, a ... announced its new name: Therabron Therapeutics , Inc. ... and bronchioles (a type of structure in the lungs ... company’s mission to develop novel protein therapeutics for the ... directors decided to change the name to mark the ...
Breaking Biology Technology:ADM and DNA2.0 Enter Into Protein Engineering Technology Access and Service Agreement 2Velocity Pharmaceutical Development, LLC and Tigercat Pharma, Inc. Announce Phase 2 Results for VPD-737 in Patients With Chronic Pruritus 2Velocity Pharmaceutical Development, LLC and Tigercat Pharma, Inc. Announce Phase 2 Results for VPD-737 in Patients With Chronic Pruritus 3Velocity Pharmaceutical Development, LLC and Tigercat Pharma, Inc. Announce Phase 2 Results for VPD-737 in Patients With Chronic Pruritus 4AeroScout Founder Joins GlassesOff's Board of Directors 2AeroScout Founder Joins GlassesOff's Board of Directors 3Maryland-based Biotech Company's Path Forward in Treating Respiratory Diseases Sparks Name Change 2
... to be held Thursday, January 17, at ... 2:00 p.m. Central ... today,announced that leading cardiothoracic surgeon Husam H. Balkhy, M.D., will,webcast a ... Hospital. The approximately 75-minute live webcast will,be available on http://www.OR-Live.com ...
... AUSTIN, Texas, Jan. 11 The Brain Injury ... in Austin, Texas with,significant physical and mental disabilities due ... other medical equipment from a,New Hampshire couple whose 13-year-old ... on February 13, 2007 at the age of 13., ...
... Leading marine scientists from across the world have issued ... carbon offsets from ocean iron fertilisation. , Published on ... the US, Japan, Hawaii, New Zealand, The Netherlands, India, ... Prof Andrew Watson of the University of East Anglia ...
Cached Biology Technology:The Wisconsin Heart Hospital Announces Live Webcast Demonstrating Breakthrough Device to Facilitate Beating Heart and Robotic Coronary Revascularization Surgery 2The Wisconsin Heart Hospital Announces Live Webcast Demonstrating Breakthrough Device to Facilitate Beating Heart and Robotic Coronary Revascularization Surgery 3Texas Boy Receives Wheelchair From New Hampshire Couple's Recently Deceased Granddaughter 2
... to significantly increase the shelf life of ... increased at room temperature storage conditions in ... is subjected to 0.45 micron filtration, and ... formulation insures consistently high levels of activity ...
... been developed to significantly increase the shelf ... Stability is increased at room temperature storage ... This product is subjected to 0.2 micron ... This formulation insures consistently high levels ...
These 25x25 square No.1 Corning cover glasses are made from No. 0211 zinc titania glass and are 0.16 to 0.19mm thick. • Approx. Pcs Oz : 102...
... Cell Cultures (ECACC) has been offering training ... government institutes for over seven years. We ... introduce candidates to cell culture and a ... specialist areas such as planning and management ...
Biology Products: