Navigation Links
Rare form of active 'jumping genes' found in mammals
Date:1/3/2013

made its discovery while studying piggyBac, an active cut-and-paste jumping gene from insects. PiggyBac got its name because it hitched a ride from one host to another on a virus. While studying how the jumping gene works, the researchers also used computational methods to search for piggyBac-like DNA sequences in the genomes of some species, including that of the little brown bat. There they found a sequence similar to piggyBac, one that didn't appear to have collected mutations that would make it inactive. Sure enough, near-identical copies were sprinkled throughout the genome, indicating that the sequence had jumped relatively recently. Craig named the find piggyBat. Her team also found that piggyBat can move within bat cells, other mammalian cells and yeast, showing that it is indeed a still-active DNA element.

Many organisms have developed systems to decrease the frequency at which jumping genes move, Craig says. Such systems are a component of immunity, protecting mammals from retroviruses, as well as from the risk that jumping genes will wreak havoc by interrupting an important gene.

Over time, the protective systems have made most mammalian jumping genes inactive. The finding that a bat species is host to an exception, combined with the fact that bats are particularly susceptible to viruses, may indicate that the systems that protect us from dangerous genetic material are not as well-developed in bats, Craig says. But whatever the reason for its presence, piggyBat "opens up a window for studying jumping gene regulation in a mammal where the element is still active," she says.

This future research should yield insights on the workings of jumping genes themselves, as well as on the protective systems that keep them in check, Craig says. Ultimately, her group hopes to custom-design jumping genes that can be used for targeted, safe and effective gene therapy, delivering genes needed to treat disease.


'/>"/>

Contact: Shawna Williams
shawna@jhmi.edu
410-955-8236
Johns Hopkins Medicine
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Embryonic development protein active in cancer growth
2. Dartmouth scientists track radioactive iodine from Japan nuclear reactor meltdown
3. Computer scientists develop an interactive field guide app for birders
4. Fish show autism-like gene expression in water with psychoactive pharmaceuticals
5. A new type of data papers designed to publish online interactive keys identifying biodiversity
6. Weight gain induced by high-fat diet increases active-period sleep and sleep fragmentation
7. Interactive eco-schools
8. Active forest management to reduce fire could help protect northern spotted owl
9. To understand childhood obesity, researchers look to inactive, fat rats
10. New Genetics educational resource promotes active learning
11. Diabetes Management Provider ActiveCare Announces Cost Savings Of Over $4,000 Per Year Per Diabetic Member
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Rare form of active 'jumping genes' found in mammals
(Date:7/11/2014)... burning in eastern New South Wales, Australia when NASA,s ... 03:35 UTC on July 11 (12:35 p.m. local time/11:35 ... eastern New South Wales (NSW), the Moderate Resolution Imaging ... the region and spotted smoke (light brown) from various ... are outlined in red. , The New South Wales, ...
(Date:7/11/2014)... USC Stem Cell scientists have set a "mouse TRAP" ... described by a recent study published in the ... line uses a technique called TRAP to extract cellular ... , Invented by scientists at the Rockefeller Institute for ... tag to the protein-making machinery, or ribosomes, of the ...
(Date:7/11/2014)... from the Max Planck Institute for Medical Research in ... understanding photosynthesis, the process by which the Earth first ... and which is therefore crucial for all higher forms ... the first direct visualization of a crucial event in ... specific protein complex, photosystem II, splits water into hydrogen ...
Breaking Biology News(10 mins):A first direct glimpse of photosynthesis in action 2
... of earth scientists report movement of warmed sea water through ... is greater than that off midocean volcanic ridges. The finding ... once considered barren. With about 71 percent of the ... under the sea, its geology, and the life it supports. ...
... German . Scientists at the Max ... have decoded the genome of the Pristionchus pacificus nematode, ... their work, which has been published in the latest ... Professor Ralf J. Sommer,s department in Tbingen have shown ...
... UC Davis researchers have defined a cellular process ... found an important starting point for identifying and ... rheumatoid arthritis, cardiovascular disease and some cancers. ... sPLA2-IIA binds to two integrins labeled alpha-V-beta-3 and ...
Cached Biology News:Ocean floor geysers warm flowing sea water 2Insight into the evolution of parasitism 2Insight into the evolution of parasitism 3UC Davis researchers discover new drug target for inflammatory disease 2
(Date:7/10/2014)... the basis of psychiatric disorders has been extremely challenging ... risk but are insufficient to cause disease. Now investigators ... Press journal Cell Stem Cell describe a ... risks interact with other risk factors or environmental exposures ... research pinpoints a genetic variant that may predispose individuals ...
(Date:7/10/2014)... RICHLAND, Wash. The lithium-ion batteries that power our ... run longer on a single charge with the help ... the porous material to replace the graphite traditionally used ... more than 10 times the energy storage capacity of ... lithium-ion battery electrode was published today in Nature ...
(Date:7/10/2014)... shelled out for crude 3-D glasses, polarized glasses, ... These basic devices, used to trick the brain ... be rendered obsolete with the introduction of new ... , TAU doctoral students Yuval Yifat, Michal Eitan, ... based on nanoantennas that could be used for ...
(Date:7/10/2014)... new alliance will see the two universities and NPL ... with business and industry and their complementary academic strengths., ... help to shape the scientific priorities of the UK. ... up to 300 high-calibre PhD students, will provide a ... NPL, the potential of the Laboratory will be grown ...
Breaking Biology Technology:New strategy could uncover genes at the root of psychiatric illnesses 2Silicon sponge improves lithium-ion battery performance 2Silicon sponge improves lithium-ion battery performance 3Projecting a 3-dimensional future 2Projecting a 3-dimensional future 3Universities of Surrey and Strathclyde selected as strategic partners in the future operation of the National Physical Laboratory 2Universities of Surrey and Strathclyde selected as strategic partners in the future operation of the National Physical Laboratory 3
... DRRX ) announced today that James E. ... NewsMakers in the Biotech Industry Investment,Conference to be ... 2007 at 11:30 a.m.,Eastern Time. (Logo: ... the presentation will be available by accessing,DURECT,s homepage ...
... Text provides cardiologists with an overview of cardiovascular genetics ... ... TORONTO, Aug. 29 /PRNewswire-FirstCall/ - GeneNews Limited (TSX: GEN),a ... and staging of virtually any disease or medical,condition, today announced ...
... Pharmaceuticals,Inc. (Amex: ANX ) a biopharmaceutical research ... for the treatment,of cancer and infectious diseases, announced ... is scheduled to present at the 2007,Thomas Weisel ... 1:30 p.m. Eastern Daylight Time. The conference takes ...
Cached Biology Technology:GeneNews' Chief Scientist Dr. C.C. Liew co-editor of new genomics reference book 2ADVENTRX Pharmaceuticals to Present at the 2007 Thomas Weisel Partners Healthcare Conference 2
... The new Adept CE 4100 high ... superb flow precision, with software drive compensation, ... from 0.001-10mL/min are selectable in 0.001mL steps. ... are inert and bio-compatible., Pumps may be ...
... angle system, 220-240 V, is used to resolve ... fragments by pulsed field gel electrophoresis (PFGE). The ... pump, 14 x 13 cm casting stand with ... thick comb, screened cap, disposable plug molds, 12 ...
... Immuno-Blot PVDF membrane and filter paper ... PVDF membrane and two sheets of thick ... blotting membrane and filter paper sandwich. These ... high binding capacity immunoblotting fit Ready Gel-sized ...
... fromStreptomyces griseolusthat inhibits protein synthesis. Acts ... eukaryote ribosomes. Reported to induce apoptosis ... promyelocytic leukemia cells, Jurkat cells, ventricular ... intracellular signals and immediate early gene ...
Biology Products: