Navigation Links
Rare childhood disease may hold clues to treating Alzheimer's and Parkinson's
Date:10/27/2013

health effects if there is too much of it -- has been looked at in the mature nerve cells of the brain.

By reducing the excess EZH2 protein that accumulated in mice genetically engineered with A-T disease, and creating a better protein balance within the nerve cells, Rutgers scientists found that mice exhibited improved muscle control, movement and coordination.

In the study, mutant mice that had A-T disease and increased levels of EZH2 were "cured" when this excess EZH2 protein was reduced. The treated mice were able to stay on a rotating rod without falling off almost as long as the mice that did not have A-T disease. By contrast, untreated A-T animals lost their balance and fell off the device almost immediately. The mice were also studied in an open area setting. While the treated A-T mice and normal mice explored a wide area of the open field, the A-T mice, with their excess EZH2 protein, were not as adventurous and stayed behind.

Rutgers scientists say the implications of these findings now need to be validated in a clinical setting. They have begun working with the A-T Clinical Center at Johns Hopkins University, collecting blood samples from children with the disease as well as their parents who carry the genes in order to reprogram them into stem cells. This will allow scientists to create human neurons like those in A-T patients and study the mechanisms that lead from ATM mutations to nerve cell disease in more detail.

The hope is that this new information can be used to develop therapeutic drugs that may result in better neuromuscular control and coordination for those with A-T disease. In addition, the scientists will work to determine whether the EZH2 protein plays a role in other more common neurodegenerative diseases, like Parkinson's and Alzheimer's and could offer a target for developing drugs to treat those brain disorders.

"What is interesting about human health and this research in particular is t
'/>"/>

Contact: Robin Lally
rlally@umc.rutgers.edu
732-932-7084 x652
Rutgers University
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Studies reveal structure of EV71, a virus causing childhood illnesses
2. How many calories does it take to reach childhood obesity prevention goals?
3. Zip code as important as genetic code in childhood obesity
4. Prenatal exposure to air pollution linked to childhood obesity
5. Washington University receives $8 million to lead international childhood malnutrition effort
6. Folic acid food enrichment potentially protective against childhood cancers
7. Leading childhood asthma group supports federal asthma action plan to reduce disparities
8. Childhood virus infection linked to prolonged seizures with fever
9. Highlighting molecular clues to the link between childhood maltreatment and later suicide
10. Key mutations discovered for most common childhood brain cancer
11. To understand childhood obesity, researchers look to inactive, fat rats
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/27/2015)... NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" ... the growing mobile commerce market, announces that its Wocket® ... first week of May, 2015 and will be fulfilling ... Gino Pereira , Chief Executive Officer ... as Wocket® enters the consumer market. We would like ...
(Date:4/17/2015)... , April 17, 2015 ... security concerns, and technological advancement to drive biometric ... until 2020   According to ... Arabia Biometric Systems Market Forecast &  Opportunities, 2020 ", biometric systems market ... projected to register growth at CAGR of over ...
(Date:4/10/2015)... , April 10, 2015 ... addition of the "Security Competitive Profiles - NEC" ... http://photos.prnewswire.com/prnh/20130307/600769) , NEC will continue to supply ... to the market, with a company focus on the ... anticipated. Winning opportunities in the ...
Breaking Biology News(10 mins):Wocket, the Smartest Wallet You Will Ever Own, Announces Shipment to Pre-order Customers 2Wocket, the Smartest Wallet You Will Ever Own, Announces Shipment to Pre-order Customers 3Saudi Arabia Biometric Systems Market to Grow at 22% Through 2020, Says TechSci Research 2Saudi Arabia Biometric Systems Market to Grow at 22% Through 2020, Says TechSci Research 3NEC Security Competitive Profile 2015 2
... Access to Research Careers) Program has announced the travel ... of Chicanos and Native Americans in Science (SACNAS) annual ... These awards are meant to promote the entry of ... mainstream of the basic science community and to encourage ...
... Fox Foundation for Parkinson,s Research and Shake It Up ... Sydney,s Garvan Institute of Medical Research to look at ... Long non-coding RNAs are complex molecules, produced from ... in the body. Unlike conventional genes, they do not ...
... have increasingly relied on the wild and weedy relatives of ... and other traits. But just like all wild plant species, ... decline and extinction due to habitat loss, pollution, and climate ... describe the latest efforts to identify and protect the wild ...
Cached Biology News:Garvan Institute receives grant to research role of long non-coding RNAs in Parkinson's disease 2Protecting the weedy and wild kin of globally important crops 2
(Date:5/26/2015)... -- Sangamo BioSciences, Inc. (NASDAQ: SGMO ) announced today that ... an update on the progress of Sangamo,s ZFP Therapeutic ® ... strategy at 1:30pm ET on Monday, June 1, 2015, at ... held in New York, NY . ... accessed via a link on the Sangamo BioSciences website in ...
(Date:5/26/2015)... -- Alere Inc. (NYSE: ALR ) (the "Company") announced today ... its Quarterly Report on Form 10-Q for the three months ... a notice from the New York Stock Exchange (the "NYSE") ... continued listing requirements under the timely filing criteria established in ... The reason for the delay relates to Company,s need ...
(Date:5/26/2015)... Global Stem Cells Group and Stem ... first cellular and regenerative medicine symposium in Barcelona Spain ... stem cell training class Oct. 10. The event will ... of Therapeutic Confrontations (CONFTERA) in Barcelona. , In ... medicine and recent advances in cellular therapies, Global Stem ...
(Date:5/26/2015)... May 26, 2015   PDI , a ... announced that Oakwood Healthcare in Dearborn, ... winning entry in Delivering the Difference ... display excellence in building collaborative relationships between infection ... healthcare facilities.  Oakwood Healthcare,s infection ...
Breaking Biology Technology:Sangamo BioSciences Announces Presentation At The Jefferies 2015 Global Healthcare Conference 2Stem Cell Training, Inc. Announces First European Symposium on Cellular and Regenerative Medicine 2Stem Cell Training, Inc. Announces First European Symposium on Cellular and Regenerative Medicine 3PDI Announces Winner in Delivering the Difference Contest 2PDI Announces Winner in Delivering the Difference Contest 3
... May 3, 2011 /PRNewswire-Asia-FirstCall/ -- 3SBio Inc. (NASDAQ: ... a leading China-based biotechnology company focused on researching, ... that it will release its first quarter 2011 ...  closes on Wednesday, May 11, 2011 at 8:00pm ...
... this year,s American Academy of AntiAging (A4M) conference, Glycation and ... in premature aging and disease. AGEs are dangerous substances that ... attaches to a protein or lipid without the presence of ... cause accelerated damage to the tissues and cells. ...
... Pharmaceuticals, Inc. (AMEX: AEN ), a developer ... announced today that after scientific review, the ongoing clinical ... multiple sclerosis (MS) has received an additional $1,594,553 in ... of Neurological Disorders and Stroke (NIH/NINDS). The clinical trial ...
Cached Biology Technology:3SBio Inc. Schedules Unaudited First Quarter 2011 Results 2At This Year's American Academy of AntiAging (A4M) Conference, Glycation and AGEs (Advanced Glycation End Products) Were Named the Leading Factors in Premature Aging and Disease 2Adeona's Multiple Sclerosis Clinical Trial Receives $1,594,553 Grant 2Adeona's Multiple Sclerosis Clinical Trial Receives $1,594,553 Grant 3Adeona's Multiple Sclerosis Clinical Trial Receives $1,594,553 Grant 4
MiniCycler thermal cycler with Hot Bonnet heated lid, holds 25x0.2ml tubes...
For demonstration of Helicobacter pylori...
... with SR-101 Labeled Substrates (red fluorescence; ... measure serine protease activation • No ... FLISP Kits utilize cell-permeable, fluorescently labeled ... measure chymotrypsin-like activity in whole living ...
... the mitochondrial transmembrane potential is ... events that occur following induction ... Detection Kit utilizes a lipophilic ... a mitochondrial activity marker. MitoLight ...
Biology Products: