Navigation Links
Rare childhood disease may hold clues to treating Alzheimer's and Parkinson's
Date:10/27/2013

Scientists at Rutgers University studying the cause of a rare childhood disease that leaves children unable to walk by adolescence say new findings may provide clues to understanding more common neurodegenerative diseases like Alzheimer's and Parkinson's and developing better tools to treat them.

In today's online edition of Nature Neuroscience, professors Karl Herrup, Ronald Hart and Jiali Li in the Department of Cell Biology and Neuroscience, and Alexander Kusnecov, associate professor in behavioral and systems neuroscience in the Department of Psychology, provide new information about A-T disease, a rare genetic childhood disorder that occurs in an estimated 1 in 40,000 births.

Children born with A-T disease have mutations in both of their copies of the ATM gene and cannot make normal ATM protein. This leads to problems in movement, coordination, equilibrium and muscle control as well as a number of other deficiencies outside the nervous system.

Using mouse and human brain tissue studies, Rutgers researchers found that without ATM, the levels of a regulatory protein known as EZH2 go up. Looking through the characteristics of A-T disease in cells in tissue culture and in brain samples from both humans and mice with ATM mutation, they found that the increase in EZH2 was a major contributing factor to the neuromuscular problems caused by A-T.

"We hope that this work will lead to new therapies to prevent symptoms in those with A-T disease," says Hart. "But on a larger level, this research provides a strong clue toward understanding more common neurodegenerative disorders that may use similar pathways. "It is a theme that has not yet been examined."

While the EZH2 protein has been shown to help determine whether genes get turned on or off, altering the body's ability to perform biological functions, necessary for maintaining good health, the Rutgers study is the first time this protein -- which can cause adverse
'/>"/>

Contact: Robin Lally
rlally@umc.rutgers.edu
732-932-7084 x652
Rutgers University
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Studies reveal structure of EV71, a virus causing childhood illnesses
2. How many calories does it take to reach childhood obesity prevention goals?
3. Zip code as important as genetic code in childhood obesity
4. Prenatal exposure to air pollution linked to childhood obesity
5. Washington University receives $8 million to lead international childhood malnutrition effort
6. Folic acid food enrichment potentially protective against childhood cancers
7. Leading childhood asthma group supports federal asthma action plan to reduce disparities
8. Childhood virus infection linked to prolonged seizures with fever
9. Highlighting molecular clues to the link between childhood maltreatment and later suicide
10. Key mutations discovered for most common childhood brain cancer
11. To understand childhood obesity, researchers look to inactive, fat rats
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/11/2014)... Dec. 09, 2014 Research and Markets ... ( http://www.researchandmarkets.com/research/twhjll/biometrics_market ) has announced the ... APAC Region 2015-2019"  report to their offering. ... market is advances in technology. With continuous advances ... solutions to the latest standard that meets the ...
(Date:12/11/2014)... , Dec. 10, 2014  That blood pressure plays ... a while. Hypertension – the medical term for high blood ... early 1800s, and the inflatable cuff that,s used in measuring ... however, mean there,s nothing new about hypertension, its triggers and ... beliefs about the condition and the best ways to treat ...
(Date:12/10/2014)... 2014 You,ve been here before: you desperately need ... your password, site key or the answer to your secret ... teacher? Today, Hoyos Labs , a ... will finally put an end to the frustration that comes ... . 1U leverages a user,s smartphone to acquire his or ...
Breaking Biology News(10 mins):Biometrics Market in the APAC Region 2015-2019: Key Vendors are 3M Cogent, NEC, Safran and Suprema 2Research points to need for new approaches to treatment of high blood pressure 2Research points to need for new approaches to treatment of high blood pressure 3Research points to need for new approaches to treatment of high blood pressure 4The Password is Finally Dead: Launch of 1U Mobile App Eliminates Need for All Usernames and Passwords 2The Password is Finally Dead: Launch of 1U Mobile App Eliminates Need for All Usernames and Passwords 3
... 6, 2011 Ceelox, Inc. (OTCBB: CELO) announced today ... which operates on computers running the Windows 7 Operating ... their authentication approach to leverage the recent capability of ... (WBF) provides support for fingerprint biometric devices through a ...
... an alternative to drugs for the prevention of esophageal ... Annual Meeting 2011, held here April 2-6. ... eating strawberries is safe and easy to consume. In ... histological grade of precancerous lesions and reduce cancer-related molecular ...
... That,s the agonizing choice some birds face, according to ... by Guelph researchers discovered that for some male birds traveling ... attracting a female when they return home. Alice Boyle, a ... Chris Guglielmo, a biologist at the University of Western Ontario, ...
Cached Biology News:Ceelox Offers Beta Release of Ceelox ID 7 for Personal Computers 2Strawberries may slow precancerous growth in esophagus 2Birds must choose between mating, migrating, study finds 2
(Date:12/22/2014)... Malvern, PA & Brussels (PRWEB) December 22, 2014 ... Education (CfPIE), the global leader of technical training ... Society for Clinical Data Management (SCDM) to ... training and certification programs —providing access to the ... The partnership extends SCDM members with 10% off when ...
(Date:12/22/2014)... 2014 /PRNewswire/ - RepliCel Life Sciences Inc. (OTCQB: REPCF) ... on the development of autologous cell therapies, announced today ... of Calgary in conjunction with co-authors from Kyoto University ... the company,s ongoing clinical research using dermal sheath cup ... The paper entitled " Hair Follicle Dermal ...
(Date:12/22/2014)... 2014 GenomeDx Biosciences today announced that a ... a genomic test for prostate cancer, was able to ... by radical prostatectomy without adjuvant therapy. Although rapid metastasis ... using tumor genomics to identify these men who have ... important advance. The study has been published online ...
(Date:12/22/2014)... The American Journal of ... research, reviews and editorials addressing developments and pathways ... published a provocative article exploring the role of ... potential treatment of prostate cancer. , The ... the possibility that there could be a connection ...
Breaking Biology Technology:CfPIE Announces Partnership with the Society for Clinical Data Management 2CfPIE Announces Partnership with the Society for Clinical Data Management 3Newly Released Peer-Reviewed Publication Further Validates RepliCel's Use of Dermal Sheath Cup Cells to Treat Pattern Baldness 2Newly Released Peer-Reviewed Publication Further Validates RepliCel's Use of Dermal Sheath Cup Cells to Treat Pattern Baldness 3Newly Released Peer-Reviewed Publication Further Validates RepliCel's Use of Dermal Sheath Cup Cells to Treat Pattern Baldness 4Newly Released Peer-Reviewed Publication Further Validates RepliCel's Use of Dermal Sheath Cup Cells to Treat Pattern Baldness 5Study Published in European Urology Shows that the Decipher Prostate Cancer Classifier is Predictive of Rapid Metastasis in High-Risk Men who have had Prostate Surgery 2Study Published in European Urology Shows that the Decipher Prostate Cancer Classifier is Predictive of Rapid Metastasis in High-Risk Men who have had Prostate Surgery 3Prostate Cancer Experts Dissect the Role of Follicle-stimulating Hormone in the Development, Progression and Potential Treatment of Prostate Cancer 2Prostate Cancer Experts Dissect the Role of Follicle-stimulating Hormone in the Development, Progression and Potential Treatment of Prostate Cancer 3Prostate Cancer Experts Dissect the Role of Follicle-stimulating Hormone in the Development, Progression and Potential Treatment of Prostate Cancer 4
... thing with IT shops right now. It's the new magic ... word and the music swells. Then we'll go skipping off ... happy customers. Yes, I was touting partnership just last week ... hard work. Partnership is the right relationship answer only if ...
... announced Wednesday it has been awarded a contract ... management hardware for a U.S. Department of Energy ... million project will develop, manufacture and demonstrate a mine ... metal-hydride storage and refueling hardware. , ,The project was ...
... Left to right: Professor James Dumesic, graduate students Steven ... researcher Won Bae Kim. Source: UW-Madison. MADISON - ... technical barrier to the efficient operation of fuel cells. ... of Wisconsin-Madison have not only cleared that barrier - ...
Cached Biology Technology:Blooming partnerships 2Blooming partnerships 3Blooming partnerships 4Modine Manufacturing to contribute to DOE's fuel-cell vehicle 2UW engineers clear bottleneck in hydrogen production 2
Request Info...
Polyclonal Antibody to CLAN...
Goat polyclonal to MLH3 ( Abpromise for all tested applications). entrezGeneID: 27030 SwissProtID: Q9UHC1...
Rabbit polyclonal to NMDAR1 e/f/g/h ( Abpromise for all tested applications)....
Biology Products: