Rare cancer-causing syndrome found, for the first time, in...(Because one of the research interests of...)
Because one of the research interests of the National Cancer Centre Singapore is breast cancer susceptibility, investigators there decided to look for evidence of the syndrome in women who developed breast cancer at 35 years of age or younger. About four percent of breast cancer in Singapore is found in younger women, researchers say.
They recruited 30 patients and their families, took detailed family histories and tested their blood for mutations in the p53 gene and the CHEK2 gene, another tumor suppressor gene found to be mutated in some patients with LFS.
They found LFS in one woman in Singapore who had been diagnosed with breast cancer at age 25. Her mother had been diagnosed with breast cancer at age 34, and died at age 35, and a sister died of a brain tumor when she was 10 years old. The patients non-identical twin sister, determined by DNA fingerprinting, does not have LFS and does not have the p53 mutation found in her affected twin.
The researchers add that establishing a detailed family history that extends back for three generations, which is necessary to make a diagnosis of LFS, can be problematic. In Singapore, many families are small and many are migrants, and it can be difficult to obtain the needed history, Lee said. That is why we focused our study on young onset breast cancer patients and tested these individuals for germ-line mutations in the p53 gene.
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| Contact: Staci Vernick Goldberg staci.goldberg@aacr.org 267-646-0616 American Association for Cancer Research Source:Eurekalert |
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