Navigation Links
Rapid venom evolution in pit vipers may be defensive
Date:7/18/2011

ausing massive internal hemorrhaging in nonresistant warm-blooded prey species, mainly rodents and birds.

The new research came out of a previous phylogenetic study of marsupials, published as a Bulletin of the American Museum of Natural History, that suggested unusually rapid evolution in one gene among a group of snake-eating opossums. The rapidly evolving gene codes for von Willebrand's factor, an important blood-clotting protein that is known to be the target of several snake-venom toxins. The association of rapid evolution in a venom-targeted gene among just those opossums known to eat pitvipers was the essential clue that prompted further study.

"This finding took us by surprise," says Sharon Jansa, associate professor in the Department of Ecology, Evolution and Behavior at the University of Minnesota and a Museum research associate. "We sequenced several genesincluding the one that codes for von Willebrand Factor (vWF)to use in a study of opossum phylogeny. Once we started to analyze the data, vWF was a real outlier. It was evolving much more rapidly than expected in a group of opossums that also, as it turns out, are resistant to pitviper venom."

The recently published research demonstrates that the rate of replacement substitutions (nucleotide changes that result in amino-acid changes) is much higher than the rate of silent substitutions (nucleotide changes that have no effect on the protein) in the von Willebrand Factor gene among pitviper-eating opossums. Typically, high rates of replacement substitutions means that the gene is under strong, sustained natural selection. That only happens in a few evolutionary circumstances.

"Most nucleotide substitutions have little or no effect on protein function, but that doesn't seem to be the case with vWF in these venom-resistant opossums," says Jansa. "The specific amino acids in vWF that interact with toxin proteins show unexpectedly high rates of replacement substitutions. These
'/>"/>

Contact: Michael Walker
walker@amnh.org
212-769-5766
American Museum of Natural History
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Study Shows Sutro Biopharmas Biochemical Protein Synthesis Technology Enables Rapid Production and Scale-Up of Biopharmaceuticals
2. Plasticity of hormonal response permits rapid gene expression reprogramming
3. University of Tennessee scientist: Flowers rapid growth rate can be traced back 65 million years
4. Genome duplication encourages rapid adaptation of plants
5. Evolution can cause a rapid reduction in genome size
6. New imaging technique provides rapid, high-definition chemistry
7. In the best youth football teams, the first team players develop their bodies more rapidly
8. Research suggests HIV causes rapid aging in key infection-fighting cells
9. New method for rapidly producing protein-polymers
10. Dana-Farber receive $5.6 million grant to develop rapid countermeasures to infectious agents
11. Microfluidic device rapidly orients hundreds of embryos for high-throughput experiments
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/18/2014)... their colleagues have built the first smartphone app ... and behavioral trends. In other words, your smartphone ... you don,t -- and how that affects you. ... stress, depression and loneliness to their academic performance, ... for example, to monitor mental health, trigger ...
(Date:9/18/2014)... which have devastated algal forests in the eastern Mediterranean ... basin if their distribution continues to expand as the ... an international team of researchers led by Dr Adriana ... the Mediterranean Institute for Advanced Studies in Spain, is ... of the team surveyed more than 1000 kilometres of ...
(Date:9/18/2014)... Becoming invisible is probably the ultimate form of camouflage: ... you. And this strategy is not as uncommon as ... Maryland Baltimore County, USA, explains that the larval life ... is one part of the anatomy that most creatures ... compound eyes have to shield each individual eye unit ...
Breaking Biology News(10 mins):New Dartmouth smartphone app reveals users' mental health, performance, behavior 2New Dartmouth smartphone app reveals users' mental health, performance, behavior 3New Dartmouth smartphone app reveals users' mental health, performance, behavior 4Tropical fish a threat to Mediterranean Sea ecosystems 2Transparent larvae hide opaque eyes behind reflections 2
... COLUMBUS, Ohio - For the first time, researchers have found ... therapy agent directly into a single living cell without a ... therapeutic biomolecules through a tiny channel and into a cell ... and his colleagues at Ohio State University describe the technique ...
... terrorized its plant-eating neighbours in South America was a lot ... found. Carnotaurus was a seven-metre-long predator with ... student Scott Persons says made it one of the fastest ... tail bones of Carnotaurus showed its caudofemoralis muscle ...
... , New York, NY (October 14, 2011) Researchers at ... uncovered a vast new gene regulatory network in mammalian cells ... The studies appear in today,s online edition of Cell ... a missing piece in the puzzle of cell regulation and ...
Cached Biology News:Researchers do precise gene therapy without a needle 2Researchers do precise gene therapy without a needle 3Vast hidden network regulates gene expression in cancer 2Vast hidden network regulates gene expression in cancer 3
(Date:9/18/2014)... D.C. (PRWEB) September 18, 2014 On ... Durbin and Sen. Jim Risch for National Lab Day ... projects from across the national laboratory system. Durbin and ... which aims to increase awareness of the reach of ... technologies and discoveries to address some of our nation's ...
(Date:9/18/2014)... Research and Markets has announced ... Report 2014" report to their offering. ... a professional and in-depth study on the current state ... report provides a basic overview of the industry including ... albumin market analysis is provided for the international markets ...
(Date:9/18/2014)...  U.S. biotech company Kultevat has strengthened ... technology developed by the Donald Danforth Plant Science ... for applications in production of natural rubber in ... developed under the direction of Roger Beachy , ... of the Danforth Plant Science Center, and is used ...
(Date:9/18/2014)... SEATTLE , Sept. 18, 2014 /PRNewswire/ - Oncothyreon ... pricing of previously announced concurrent but separate underwritten offerings ... price to the public of $2.00 per share, for ... of its Series A Convertible Preferred Stock at a ... expected gross proceeds of $20 million. Each share of ...
Breaking Biology Technology:Lab Day Highlight Labs' Contribution to U.S. Competitiveness and Innovation 2Lab Day Highlight Labs' Contribution to U.S. Competitiveness and Innovation 3Global Human Albumin Industry Report 2014 2Global Human Albumin Industry Report 2014 3Kultevat obtains license of gene switch technology 2Oncothyreon Prices $40 Million Concurrent Public Offerings of Common Stock and Preferred Stock 2Oncothyreon Prices $40 Million Concurrent Public Offerings of Common Stock and Preferred Stock 3
... 11 /PRNewswire-FirstCall/ - GeneNews Limited (TSX: GEN), a ... the early detection of diseases and personalized health ... a agreement allowing Centocor Research & Development, Inc. ... biomarker program. Additional terms of the agreement were ...
... Hovione announced today,that it has agreed with Pfizer to ... This site manufactures,intermediates for Lipitor active pharmaceutical ingredient. , ... had a number of owners starting in 1984 with ... and now Hovione. Over,the last 10 years Pfizer has ...
... McCulley/Cuppan announced today the launch of a new series of web-based ... The web delivered "short" courses are one hour in duration and ... writing skills. , ... Salt Lake City, Utah (PRWEB) ...
Cached Biology Technology:GeneNews provides Centocor access to its osteoarthritis program 2Hovione Buys Pfizer's Loughbeg API Facility 2Hovione Buys Pfizer's Loughbeg API Facility 3McCulley/Cuppan Announced Today The Launch Of A New Series Of Web-Based Training Programs For Professionals In The Biopharmaceutical And Life Science Industries 2McCulley/Cuppan Announced Today The Launch Of A New Series Of Web-Based Training Programs For Professionals In The Biopharmaceutical And Life Science Industries 3
...
Agarose for baculovirus plaque assays which allow optimal growth of plated insect cells....
BD BaculoGold Max-XP Insect Cell Medium 1 Liter...
Mycoplasma and virus tested...
Biology Products: