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RNA emerges from DNA's shadow
Date:7/10/2008

serious disorders caused by deleterious mutations in specific genes, as opposed to problems with the RNA itself. Jacobson also presented one of the most exciting developments, a molecule that overcomes a common deficiency in genes that prevents their being read right up to the end of their sequence during transcription. Jacobson pointed out that there are about 2400 human genetic disorders resulting from mutations that cause genes to be incompletely read, including cystic fibrosis and muscular dystrophy. A drug based on the molecule is now entering trials that could lead to it becoming generally available. Results so far indicate dramatic improvements in both cystic fibrosis and muscular dystrophy sufferers, although it is only suitable for those disorders caused by the presence of a premature stop sign in a gene sequence, as a result of a mutation. It does though highlight the huge therapeutic potential of the research into RNA and its quality control.

Significant progress has been made in different aspects of RNA research over the last decade or more, leading to the current situation where many groups are working on different aspects of the problem. The challenge being met by the ESF's RNAQuality Programme is to bring these groups together, and make Europe a much greater force in the field, according to Jim Anderson, from Marquette University's Department of Biological Sciences in the US.

Another important aspect of RNA research lies in the interaction between DNA transcription, and the physical structure both of the membrane-bound cell nucleus and the genome coiled within it. Genes are transcribed within the nucleus and the resulting RNA molecules then emerge through small holes that are connected to the genome by proteins called nuclear pore complexes. In one of the presentations, Nick Proudfoot from Oxford University in the UK explained how some genes are enhanced by being close to the nuclear pore complex, indicating a close relationship be
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Contact: Angela Michiko Hama
mhama@esf.org
0033-388-762-149
European Science Foundation
Source:Eurekalert

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