Navigation Links
RNA aptamers targeted to plasminogen activator inhibitor
Date:6/19/2014

New Rochelle, NY, June 19, 2014Plasminogen activators are proteins involved in the breakdown of blood clots, and an elevated level of plasminogen activator inhibitor-1 (PAI-1) is associated with an increased risk for clotting and cardiovascular disease. No PAI-1 inhibitors are currently available for clinical use, but a novel therapeutic approach using a targeted RNA aptamer drug that has been shown to block PAI-1 activity and prevent PAI-1-associated vascular events is described in Nucleic Acid Therapeutics, a peer-reviewed journal from Nucleic Acid Therapeutics. The article is available free on the Nucleic Acid Therapeutics website.

Jared Damare, Stephanie Brandal, and Yolanda Fortenberry, Johns Hopkins University School of Medicine, Baltimore, MD, designed a library of small RNA molecules that target different regions of PAI-1. They then screened the library and enriched for the aptamers that were the most selective for binding to and inhibiting the function of PAI-1. The authors demonstrate the ability of these RNA aptamers to prevent PAI-1 from interacting with plasminogen activators in the article "Inhibition of PAI-1 Antiproteolytic Activity Against tPA by RNA Aptamers."

"Even beyond the admirable care and rigor of the work, the therapeutic significance lies in the authors addressing a vital concern: the identification of an aptamer that can specifically disrupt the target function of PAI-1 without inhibiting its other functions," says Executive Editor Graham C. Parker, PhD, The Carman and Ann Adams Department of Pediatrics, Wayne State University School of Medicine, Children's Hospital of Michigan, Detroit, MI.

Nucleic Acid Therapeutics is under th
'/>"/>

Contact: Vicki Cohn
vcohn@liebertpub.com
914-740-2100
Mary Ann Liebert, Inc./Genetic Engineering News
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Single protein targeted as the root biological cause of several childhood psychiatric disorders
2. Tiny probes shine brightly to reveal the location of targeted tissues
3. 11th International Congress on Targeted Anticancer Therapies
4. Study opens new prospects for developing new targeted therapies for breast cancer
5. Protein targeted for cancer drug development is essential for normal heart function
6. With early, obvious benefit of a targeted cancer drug, should expensive clinical testing continue?
7. Targeted culling of deer controls disease with little effect on hunting
8. Researchers use nanoscale patches to sensitize targeted cell receptors
9. Fruit pest targeted by genomic research
10. Targeted treatment can significantly reduce relapse in children with AML leukemia
11. Targeted synthesis of natural products with light
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
RNA aptamers targeted to plasminogen activator inhibitor
(Date:3/12/2015)... , March 12, 2015 IriTech, a ... a member of the Texas Instruments Design Network, announced ... has demonstrated its IriShield USB MK2120U device during ... facility for pension distribution. The iris ... to be marketed in India ...
(Date:3/12/2015)... March 12, 2015 Beta ... identity and access management (IAM) solution for a ... With Beta System,s new IAM package, customers benefit ... gleaned from multiple IAM implementations across different industries. ... as well as any necessary services and consulting. ...
(Date:3/11/2015)... 2015 Research and Markets ( http://www.researchandmarkets.com/research/3p32qm/access_control ... Control Market by Product, Application & By Geography - ... their offering. , This report predicts that ... billion by 2020, with an estimated CAGR of 10.6%. ... products types such as contact cards & readers, contactless ...
Breaking Biology News(10 mins):Indian States See IriTech's Scanner Bolstering Efficiency of Authentication for Aadhaar 2Indian States See IriTech's Scanner Bolstering Efficiency of Authentication for Aadhaar 3Beta Systems Fast Forward IAM Available Now: a Standardized IAM Package at a Fixed Price 2Global Access Control (Cards & Readers, Biometrics, Controllers, Management Software) Market 2015-2020 - Analysis of the $10 Billion Market 2
... BOULDER--Large-scale fires in a western or southeastern state can ... a few weeks as the state,s entire motor vehicle ... research by scientists at the National Center for Atmospheric ... The paper, "Estimates of CO2 from fires in ...
... they could detect toxic levels of acetaminophen in laboratory ... This study by the National Institute of Environmental Health ... could be a first step in developing accurate new ... of acetaminophen, the active ingredient in many over-the-counter pain ...
... YORK -- Researchers have discovered the secrets to ... programs. A three-year study entitled "Greener Voices" proves ... when given responsibility for decision making and planning. ... past two decades. Gardens are popping up in ...
Cached Biology News:US fires release large amounts of carbon dioxide 2US fires release large amounts of carbon dioxide 3Unique pattern of gene expression can indicate acetaminophen overdose 2Children's gardens mushrooming 2
(Date:3/29/2015)... Texas , March 29, 2015 /PRNewswire/ ... presentation of important study data showing the ... in 1,599 gynecologic cancer samples. Using Caris ... profiling service, researchers identified expression of programmed ... cancers independent of histology while its ligand ...
(Date:3/27/2015)... March 27, 2015 Earlier this year, ... promotion of hair regrowth in adult men and women ... or Norwood Hamilton classifications of IIa-V and Fitzpatrick Classification ... plagued by products that over-promise and under-deliver, FDA Clearance ... faith and confidence among more than 80 million men ...
(Date:3/27/2015)... 27. März 2015  Peter Walter wurde ... Science für seine bahnbrechende Arbeit ausgewählt, die ... transportiert werden, sowie für die Entschlüsselung der ... auf Stress nutzen, der mit der Ansammlung ... Professor für Biochemie an der University of ...
(Date:3/27/2015)... 2015   SurePure, Inc . (OTCQB: SURP), ... that the Company has completed the verification process ... SurePure ("SURP") securities on OTCQB, an electronic quote ... development stage companies. On March 26, ... requirements designed to improve marketplace integrity and enhance ...
Breaking Biology Technology:Caris Life Sciences' Multiplatform Tumor Profiling Technology Identifies Expression of PD-1 and PD-L1 in Gynecologic Malignancies 2Caris Life Sciences' Multiplatform Tumor Profiling Technology Identifies Expression of PD-1 and PD-L1 in Gynecologic Malignancies 3Caris Life Sciences' Multiplatform Tumor Profiling Technology Identifies Expression of PD-1 and PD-L1 in Gynecologic Malignancies 4Dr. Robert Leonard Applauds FDA Clearance of Capillus272Pro™ Hair Loss Laser Cap 2Deutschstämmiger Zellbiologe Peter Walter gewinnt den Vilcek Prize in Biomedical Science 2015 2Deutschstämmiger Zellbiologe Peter Walter gewinnt den Vilcek Prize in Biomedical Science 2015 3Deutschstämmiger Zellbiologe Peter Walter gewinnt den Vilcek Prize in Biomedical Science 2015 4SurePure Completes Verification and Approved for Trading on the OTCQB Marketplace 2
... Inc. (NYSE Amex: YMI ; TSX: YM) ... of 25,000,000 common shares of the Company, for total ... with the offering, the Company also granted the underwriters ... common shares to cover over-allotments, if any. The Company ...
... Pier Pharmaceuticals Inc.(formerly known as Steady Sleep Rx Co.), ... of sleep related breathing disorders (SRBDs), announced today the ... & President and his election to the Board of ... will be responsible for spearheading the clinical, regulatory, IP ...
... Catal de Nanotecnologia (ICN), in Barcelona, has demonstrated a device ... key step in developing the spin computers of the future. ... the journal Science. The authors are Marius V. Costache and ... the Physics and Engineering of Nanodevices Group at ICN. ...
Cached Biology Technology:YM BioSciences Closes Public Offering of Common Shares 2YM BioSciences Closes Public Offering of Common Shares 3Pier Pharmaceuticals Names Peter Letendre as Chief Executive Officer, President and Director 2A 'spin ratchet': A new electronic structure for generating spin current 2
... large numbers of samples may be carried out ... which requires minimum operator attention. System control ... and interface CE 4900. The elegant, powerful ... Windows XP and Windows 98 and 2000., The ...
... Highly nutritious peptone, used ... production of bacterial toxins, ... of bacteria with high ... Haemophilus, Neisseria, Pasteurella, Salmonella ...
... Human Raji cells were cultured in RPMI 1640 ... the log phase of growth. In order ... cells were fixed in acetone-methanol. The cells ... coated slide, with each wells surface specifically treated ...
... Human 293 cells were cultured in Minimum ... harvested at the log phase of growth. ... native forms, cells were fixed in acetone-methanol. ... mm) adhesive coated slide, with each wells surface ...
Biology Products: