Navigation Links
RNA aptamers targeted to plasminogen activator inhibitor
Date:6/19/2014

New Rochelle, NY, June 19, 2014Plasminogen activators are proteins involved in the breakdown of blood clots, and an elevated level of plasminogen activator inhibitor-1 (PAI-1) is associated with an increased risk for clotting and cardiovascular disease. No PAI-1 inhibitors are currently available for clinical use, but a novel therapeutic approach using a targeted RNA aptamer drug that has been shown to block PAI-1 activity and prevent PAI-1-associated vascular events is described in Nucleic Acid Therapeutics, a peer-reviewed journal from Nucleic Acid Therapeutics. The article is available free on the Nucleic Acid Therapeutics website.

Jared Damare, Stephanie Brandal, and Yolanda Fortenberry, Johns Hopkins University School of Medicine, Baltimore, MD, designed a library of small RNA molecules that target different regions of PAI-1. They then screened the library and enriched for the aptamers that were the most selective for binding to and inhibiting the function of PAI-1. The authors demonstrate the ability of these RNA aptamers to prevent PAI-1 from interacting with plasminogen activators in the article "Inhibition of PAI-1 Antiproteolytic Activity Against tPA by RNA Aptamers."

"Even beyond the admirable care and rigor of the work, the therapeutic significance lies in the authors addressing a vital concern: the identification of an aptamer that can specifically disrupt the target function of PAI-1 without inhibiting its other functions," says Executive Editor Graham C. Parker, PhD, The Carman and Ann Adams Department of Pediatrics, Wayne State University School of Medicine, Children's Hospital of Michigan, Detroit, MI.

Nucleic Acid Therapeutics is under the editorial leadership of Co-Editors-in-Chief Bruce A. Sullenger, PhD, Duke Translational Research Institute, Duke University Medical Center, Durham, NC, and C.A. Stein, MD, PhD, City of Hope National Medical Center, Duarte, CA; and Executive Editor Graham C. Parker, PhD.


'/>"/>

Contact: Vicki Cohn
vcohn@liebertpub.com
914-740-2100
Mary Ann Liebert, Inc./Genetic Engineering News
Source:Eurekalert  

Related biology news :

1. Single protein targeted as the root biological cause of several childhood psychiatric disorders
2. Tiny probes shine brightly to reveal the location of targeted tissues
3. 11th International Congress on Targeted Anticancer Therapies
4. Study opens new prospects for developing new targeted therapies for breast cancer
5. Protein targeted for cancer drug development is essential for normal heart function
6. With early, obvious benefit of a targeted cancer drug, should expensive clinical testing continue?
7. Targeted culling of deer controls disease with little effect on hunting
8. Researchers use nanoscale patches to sensitize targeted cell receptors
9. Fruit pest targeted by genomic research
10. Targeted treatment can significantly reduce relapse in children with AML leukemia
11. Targeted synthesis of natural products with light
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
RNA aptamers targeted to plasminogen activator inhibitor
(Date:11/22/2016)... MINNETONKA, Minn. , Nov. 22, 2016   ... that supports the entire spectrum of clinical research, is ... by Medical LiveWire Healthcare and Life Sciences Awards ... This award caps off an unprecedented year of recognition ... clinical trials for over 15 years. iMedNet ...
(Date:11/16/2016)... , Nov. 16, 2016 Sensory Inc ... and security for consumer electronics, and VeriTran ... and retail industry, today announced a global partnership ... way to authenticate users of mobile banking and ... TrulySecure™ software which requires no specialized biometric ...
(Date:6/27/2016)... 2016 Research and Markets has announced the ... report to their offering. The ... to grow at a CAGR of 12.28% during the period ... an in-depth market analysis with inputs from industry experts. The report ... years. The report also includes a discussion of the key vendors ...
Breaking Biology News(10 mins):
(Date:12/8/2016)... to fuel Philadelphia,s innovative digital ... Southeastern Pennsylvania (" Ben Franklin "); Independence ... Cross; and Safeguard Scientifics ("Safeguard") (NYSE: SFE ... funding initiative over a four year period to grow ... burgeoning economic vitality in digital health, Ben Franklin ...
(Date:12/7/2016)... ... December 07, 2016 , ... ... that it has become a Wonderware Certified System Integrator Partner. Huffman Engineering ... Schneider Electric Software. , “The System Integrator Partner certification gives customers confidence that ...
(Date:12/7/2016)... , Dec. 7, 2016  Nordion, a standalone ... Atomics (GA), welcome today,s award by the United ... Administration (NNSA) of the Phase II cooperative agreement ... Nordion and the University of Missouri Research Reactor ... will support the establishment of a new, reliable ...
(Date:12/7/2016)... 7, 2016  Genprex, Inc. a biopharmaceutical company ... treatments, today announced that it has retained ICR ... strategic communications and advisory firm, to develop and ... will combine investor relations, public relations and digital ... profile of Genprex and its lead candidate Oncoprex, ...
Breaking Biology Technology: