Navigation Links
RI Hospital: Absence of specific enzyme in cartilage can lead to benign tumors in mice
Date:7/18/2013

PROVIDENCE, R.I. Rhode Island Hospital researchers have found that the absence of the Shp-2 enzyme near specialized cartilage cells can lead to the development of multiple benign cartilage tumors in mice, a model that recapitulates the rare human tumor syndrome metachondromatosis. Shp2 is an enzyme in the cell that regulates the activity of other proteins and signaling pathways. Mice lacking Shp2 formed two types of tumors: enchondromas and osteochondromas, and also developed deformed joints. The study is published online in advance of print in the journal Nature.

"Transgenic mouse models of human disease are powerful tools to gain a better understanding of disease processes and to test novel treatments," said lead author, Wentian Yang, Ph.D., of the department of orthopedics at Rhode Island Hospital. "In humans, some of these benign tumors will progress to malignant cartilage tumors, called chondrosarcomas, which are even more serious since they spread and can be fatal."

He continued, "Knowing the cell of origin for tumor formation can be helpful in developing new treatments since each type of cell has its weak points. Our research led to the discovery of a novel cartilage stem/progenitor cell population that is the cell of origin for the tumors in our model, and to the identification of a potential therapy for this rare disease. In the future, our model may also be useful for developing novel treatments for some forms of chondrosarcoma, a type of bone cancer."

Injury to the growth plate has been the assumed reason for the formation of osteochondromas, which look similar to a growth plate that has taken off in the wrong direction, causing bone and cartilage to grow out of the bone. This research demonstrates that one cause of osteochondromas is a molecular abnormality in an enzyme in a tiny group of cells near the growth plate, resulting in often large tumors growing out of the bone. These tumors are a very common in children.

"These findings put us one step closer to understanding how these tumors form," Yang said. "The next step will be to develop a way to stop the tumors from growing at an early stage so that they do not have to be surgically removed."


'/>"/>

Contact: Ellen Slingsby
eslingsby@lifespan.org
401-444-6421
Lifespan
Source:Eurekalert

Related biology news :

1. Rhode Island Hospital: Adult entertainment workers likely to benefit from health care intervention
2. RI Hospital: Use of PMP may increase demand for drug treatment, reduce painkiller abuse
3. Viable and fertile fruit flies in the absence of histone H3.3
4. The absence of elephants and rhinoceroses reduces biodiversity in tropical forests
5. Researchers create method to rapidly identify specific strains of illness
6. Epigenetic biomarkers may predict if a specific diet and exercise regimen will work
7. Turtle genome analysis sheds light on the development and evolution of turtle-specific body plan
8. Cutting specific pollutants would slow sea level rise
9. In autism, age at diagnosis depends on specific symptoms
10. Molecular basis identified for tissue specific immune regulation in the eye and kidney
11. Bisphenol A affects sex-specific reproductive behaviors in a monogamous animal species
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/15/2016)... and BADEN-BADEN, Germany , December 15, ... global financial services provider, today announced an agreement with NuData ... biometrics, to join forces. The partnership will enable clients to ... in compliance with local data protection regulation. ... In order to provide ...
(Date:12/15/2016)... ... has announced the addition of the "Global Military Biometrics Market 2016-2020" ... global military biometrics market to grow at a CAGR of 7.5% during ... on an in-depth market analysis with inputs from industry experts. The report ... The report also includes a discussion of the key vendors operating in ...
(Date:12/15/2016)... HILLS, Mich. , Dec. 15, 2016  There ... unlocking car doors or starting the engine. Continental will ... in Las Vegas . Through the ... (Passive Start and Entry) and biometric elements, the international ... field of vehicle personalization and authentication. "The ...
Breaking Biology News(10 mins):
(Date:1/18/2017)... 2017   Parent Project Muscular Dystrophy (PPMD) , ... Duchenne muscular dystrophy (Duchenne) , today announced a $600,000 ... of Technology (NJIT) and Talem Technologies (Talem) as part ... to assist people living with Duchenne. PPMD is ... an embedded computer, software, a force sensor and a ...
(Date:1/18/2017)... ... January 18, 2017 , ... Total Orthopedics and Sports Medicine ... Solofuse-P™. The operation took place on Wednesday, January 11, 2017 at Long Island ... anterior cervical discectomy and fusion on a 42 year old female who was ...
(Date:1/18/2017)... ... January 18, 2017 , ... Announced in December ... Institutes (MII). U.S. Secretary of Commerce Penny Pritzker has announced the award of ... of Defense has announced the award of a new Advanced Regenerative Manufacturing Institute ...
(Date:1/18/2017)... ... 18, 2017 , ... Researchers from a new study are stating that if levels ... prostate cancer treatment, this indicates there is still remaining prostate cancer cells that are more ... PSA test has always been an indicator of whether a man’s prostate cancer is ...
Breaking Biology Technology: