Navigation Links
'REST' is crucial for the timing of brain development
Date:3/2/2012

Upon fertilisation, a single cell is formed when egg and sperm fuse. Our entire body, with more than 200 specialised cell types and billions of cells are formed from this single cell. It is a scientific mystery how the early stem cells know what cell type to become, but a precise timing of the process is crucial for correct development and function of our body. Researchers across the world chase knowledge about our stem cells, as this knowledge holds great promises for development of treatment against several major diseases. Researchers from BRIC, University of Copenhagen, have just shown that the molecule REST acts as an adapter in stem cells, coupling molecular on-off switches with neural genes and thereby times neuronal development.

"REST secure neuronal genes to be turned off in our stem cells until the correct time point in fetal life, where the molecule is lost and development of the nervous system begins. Our results are very important for the understanding of how genes are turned on and off during fetal development, but also relates to disease development such as cancer. Hopefully, our future studies of REST will contribute to the development of new types of treatments," says Associate Professor and Group Leader at BRIC, Klaus Hansen.

Genetic switches

All our cells contain the same DNA, yet they can develop into specialised cells with different shapes and functions. This ability is due to only selective genes being turned on in for example neuronal cells and other genes in liver cells and skin cells. Postdoc Nikolaj Dietrich from Klaus Hansen's laboratory has been the main driver of the investigation:

"Our results show that REST act as an adapter for the protein complexes called PRCs, connecting these complexes to neuronal genes. The PRCs are genetic switches turning off genes and therefore REST and the PRCs act in concert to shutdown neuronal genes. A similar mechanism has previously been described in frui
'/>"/>

Contact: Klaus Hansen
klaus.hansen@bric.ku.dk
(45) 21-15-55-64
University of Copenhagen
Source:Eurekalert

Page: 1 2

Related biology news :

1. Floor of oldest forest discovered in Schoharie County
2. Reversing Alzheimers gene blockade can restore memory, other cognitive functions
3. Study shows earthworms to blame for decline of ovenbirds in northern Midwest forests
4. Mercyhurst research aims to predict impact of invasive forest pest
5. Florida State chemist to receive prestigious award for rising faculty stars
6. Study: Nations urban forests losing ground
7. As climate change increases forest fires, smoke forecasting could help protect public health
8. AAAS-SFU research: Controlling forest fires
9. First industrial-scale foam forming research environment for forest sector
10. New procedure repairs severed nerves in minutes, restoring limb use in days or weeks
11. Satellite study reveals critical habitat and corridors for worlds rarest gorilla
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/30/2014)... 2014--Sea monkeys have captured the popular attention of both ... life cycle -- sold as dehydrated eggs, these tiny ... more than a tank of salt water. , ... other zooplankton, brine shrimp vertically migrate in large groups ... the surface at night and retreating deeper during the ...
(Date:9/30/2014)... team of environmental scientists and engineers, led by ... a three-year, $5.25 million grant from the U.S. ... Research to make a direct positive impact on ... and disposal of radioactive contaminants. , "Understanding the ... dealing with environmental aspects of nuclear technologies is ...
(Date:9/30/2014)... can live in almost any aquatic environment on Earth, ... many species are pushed to the limit. The amount ... prove critical for how different species cope in the ... University of Gothenburg, published in the scientific journal ... change continues apace thanks to increasing levels of greenhouse ...
Breaking Biology News(10 mins):Laser-guided sea monkeys show how zooplankton migrations may affect global ocean currents 2Researchers get $5.25 million to advance nuclear technologies in South Carolina 2Shape up quickly -- applies to fish, too! 2
... the Bellvitge Biomedical Research Institute (IDIBELL) at the ... into how the IDPN nitrile causes neurological syndromes ... (ALS), a severe neuromuscular degenerative disease. The study, ... in Neuropathology and Applied Neurobiology journal. ...
... to dust off the garden tables and chairs. But garden furniture ... covered with a slimy film of algae, moss, bacteria and fungi ... hoping that they can solve this problem by incorporating titanium dioxide ... adding a little bit of sunlight. When these titanium dioxide molecules ...
... German . Zebrafish share most organ systems ... the causes of human diseases like cancer or heart diseases. ... With the European Zebrafish Resource Center (EZRC), Karlsruhe Institute of ... such lines in Europe. The EZRC is funded jointly by ...
Cached Biology News:Poisoning from industrial compounds can cause similar effects to ALS 2Cleaning with sunlight 2Zebrafish -- the stars of biomedicine 2
(Date:10/2/2014)... 2014 Permian Plastics, http://www.permianplastics.com ... Louis, Missouri, area on October 24th, 1994. Since ... plastic injection molder in the Midwest. The company operates ... supplier to many Fortune 500 clients. , Permian Plastics ... of the way, from concept to completion, going the ...
(Date:10/2/2014)... 02, 2014 The National Institutes ... (LLNL) a grant today to develop an electrode ... understand how the brain works through unprecedented resolution ... of NIH's efforts to support President Obama's BRAIN ... new research effort to revolutionize our understanding of ...
(Date:10/2/2014)... 2 de octubre de 2014 Laborie Medical ... Ontario , ha completado la adquisición de Unisensor ... Unisensor tiene su sede central sita en Wiesendangen, Suiza, ... Portsmouth, New Hampshire . Unisensor está ... de alta resolución para evaluar la presión y valores ...
(Date:10/2/2014)... WALTHAM, Mass. , Oct. 2, 2014 /PRNewswire/ ... and Drug Administration has granted Fast Track designation ... for the treatment of sickle cell disease.  NKTT120 ... iNKT cells, a regulatory T cell that has ... organ damage in preclinical models of sickle cell ...
Breaking Biology Technology:Permian Plastics LLC Celebrates 20 Years As Leading Manufacturer of Plastic Molds 2NIH taps Lawrence Livermore to Develop Sophisticated Electrode Array System to Monitor Brain Activity 2NIH taps Lawrence Livermore to Develop Sophisticated Electrode Array System to Monitor Brain Activity 3NIH taps Lawrence Livermore to Develop Sophisticated Electrode Array System to Monitor Brain Activity 4LABORIE adquiere Unisensor AG y Unisensor USA, Inc. 2FDA Grants Fast Track Designation to NKT Therapeutics' NKTT120 for the Treatment of Sickle Cell Disease 2
... 15 MannKind,Corporation (Nasdaq: MNKD ), focused on ... today that it,will present at the UBS Global Life ... (ET) at the Grand Hyatt in New York., ... web cast of the,presentation in the Investor Relations section ...
... Join as Company Enters Commercialization Phase, NAPLES, ... TO ETHANOL(TM), the most advanced third generation biofuels,technology, ... with the,appointments Greg Schlicht as Senior Vice President ... as Senior Program Manager., Mr. Schlicht will ...
... Sept. 15 Insmed Inc. (Nasdaq:,INSM) a developer ... Allan, Ph.D., CEO of Insmed, will present at ... will be discussing,the Company,s perspective on the potential ... will also Chair a panel on this topic ...
Cached Biology Technology:Algenol Biofuels Further Strengthens Team With Key Appointments 2Insmed to Present at Biosimilars 2008 Conference 2
Human SEAP ORF, provided in a pORF plasmid. pORF is an expression plasmid selectable with Ampicillin....
... of purified RNA samples., , This product ... aqueous RNA samples that have been pre-purified ... silica, oligo dT etc or other kits. ... necessary components for the stabilization of nanogram ...
... These 2800mL wide mouth PYREX Fernbach-style culture ... center of the flask bottom to achieve ... triple baffled flasks have a Delong-style 38mm ... steel closures. For plastic closures see Nos. ...
... template is designed to allow neomycin/kanamycin selection ... FRT-PGK-gb2-neo-FRT template encodes the neomycin/kanamycin resistance gene ... expression of kanamycin resistance in E.coli ... expression of neomycin resistance in mammalian cells. ...
Biology Products: